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Osbpl1a oxysterol binding protein-like 1A [ Mus musculus (house mouse) ]

Gene ID: 64291, updated on 11-Apr-2024

Summary

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Official Symbol
Osbpl1aprovided by MGI
Official Full Name
oxysterol binding protein-like 1Aprovided by MGI
Primary source
MGI:MGI:1927551
See related
Ensembl:ENSMUSG00000044252 AllianceGenome:MGI:1927551
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm753; ORP-1; Osbpl1b; G430090F17Rik
Summary
Predicted to enable cholesterol binding activity and sterol transporter activity. Predicted to act upstream of or within lipid transport. Predicted to be located in late endosome and organelle membrane contact site. Predicted to be active in cytosol; intracellular membrane-bounded organelle; and membrane. Is expressed in several structures, including central nervous system; genitourinary system; immune system; liver; and retina. Orthologous to human OSBPL1A (oxysterol binding protein like 1A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 23.6), frontal lobe adult (RPKM 14.8) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 A1; 18 6.78 cM
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (12886955..13074933, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (12753898..12941871, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 39C Neighboring gene microRNA 1948 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene calcium binding tyrosine phosphorylation regulated Neighboring gene predicted gene, 52343 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:12966807-12966996 Neighboring gene predicted gene, 36439 Neighboring gene STARR-seq mESC enhancer starr_43844 Neighboring gene STARR-seq mESC enhancer starr_43846 Neighboring gene STARR-seq mESC enhancer starr_43847 Neighboring gene ribosomal protein S8 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9448 Neighboring gene impact, RWD domain protein Neighboring gene histamine receptor H4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sterol binding by OSBP-related protein 1L regulates late endosome motility and function. Vihervaara T, et al. Cell Mol Life Sci, 2011 Feb. PMID 20690035
  2. Identification of novel host cell binding partners of Oas1b, the protein conferring resistance to flavivirus-induced disease in mice. Courtney SC, et al. J Virol, 2012 Aug. PMID 22623793, Free PMC Article
  3. Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis. Yan D, et al. Arterioscler Thromb Vasc Biol, 2007 May. PMID 17303778
  4. An evolutionary scenario for genomic imprinting of Impact lying between nonimprinted neighbors. Okamura K, et al. DNA Res, 2004 Dec 31. PMID 15871461
  5. An oxysterol-binding protein family identified in the mouse. Anniss AM, et al. DNA Cell Biol, 2002 Aug. PMID 12215260

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in organelle membrane contact site ISO
Inferred from Sequence Orthology
more info
  
is_active_in perinuclear endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
oxysterol-binding protein-related protein 1
Names
OSBP-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252489.1 → NP_001239418.1  oxysterol-binding protein-related protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001239418.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a large portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK132676, BC076637, BG092905, BY715608
    Consensus CDS
    CCDS57115.1
    UniProtKB/TrEMBL
    A0A3Q4EI24, Q3V156
    Related
    ENSMUSP00000113914.2, ENSMUST00000119512.8
    Conserved Domains (1) summary
    pfam01237
    Location:156 → 542
    Oxysterol_BP; Oxysterol-binding protein

  2. NM_001252490.1 → NP_001239419.1  oxysterol-binding protein-related protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001239419.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a large portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3, 4, 5 and 6 encode the same isoform (3), which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    BC076637, BG092905, DV068702
    Consensus CDS
    CCDS57114.1
    UniProtKB/TrEMBL
    Q3UZK3
    Related
    ENSMUSP00000112681.2, ENSMUST00000117361.8
    Conserved Domains (1) summary
    pfam01237
    Location:35 → 427
    Oxysterol_BP; Oxysterol-binding protein

  3. NM_001252491.2 → NP_001239420.1  oxysterol-binding protein-related protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001239420.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a large portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3, 4, 5 and 6 encode the same isoform (3), which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC102055
    Consensus CDS
    CCDS57114.1
    UniProtKB/TrEMBL
    Q3UZK3
    Related
    ENSMUSP00000113735.2, ENSMUST00000118313.8
    Conserved Domains (1) summary
    pfam01237
    Location:35 → 427
    Oxysterol_BP; Oxysterol-binding protein

  4. NM_001252492.1 → NP_001239421.1  oxysterol-binding protein-related protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001239421.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a large portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3, 4, 5 and 6 encode the same isoform (3), which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK168366, BC092247, BG092905, CO044459
    Consensus CDS
    CCDS57114.1
    UniProtKB/TrEMBL
    Q3UZK3
    Related
    ENSMUSP00000113841.2, ENSMUST00000121808.8
    Conserved Domains (1) summary
    pfam01237
    Location:35 → 427
    Oxysterol_BP; Oxysterol-binding protein

  5. NM_001252493.1 → NP_001239422.1  oxysterol-binding protein-related protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001239422.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and 3' UTR, lacks a large portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3, 4, 5 and 6 encode the same isoform (3), which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC102055
    Consensus CDS
    CCDS57114.1
    UniProtKB/TrEMBL
    Q3UZK3
    Related
    ENSMUSP00000112895.2, ENSMUST00000121888.8
    Conserved Domains (1) summary
    pfam01237
    Location:35 → 427
    Oxysterol_BP; Oxysterol-binding protein

  6. NM_207530.3 → NP_997413.2  oxysterol-binding protein-related protein 1 isoform 1

    See identical proteins and their annotated locations for NP_997413.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC131672, AY536214, BC076637, BG092905
    Consensus CDS
    CCDS29067.1
    UniProtKB/Swiss-Prot
    O88318, Q3TH97, Q673L8, Q6DFU6, Q91XL9
    Related
    ENSMUSP00000073957.5, ENSMUST00000074352.11
    Conserved Domains (5) summary
    COG0666
    Location:38 → 208
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd13285
    Location:229 → 352
    PH_ORP1; Human Oxysterol binding protein related protein 1 Pleckstrin homology (PH) domain
    sd00045
    Location:43 → 78
    ANK; ANK repeat [structural motif]
    pfam01237
    Location:548 → 940
    Oxysterol_BP; Oxysterol-binding protein
    pfam12796
    Location:10 → 111
    Ank_2; Ankyrin repeats (3 copies)

RNA

  1. NR_045524.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and lacks a large portion of the 5' region, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK133806, BB667982, BG092905, BY248497, BY249673, CO426253
    Related
    ENSMUST00000234428.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    12886955..13074933 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526144.4 → XP_006526207.1  oxysterol-binding protein-related protein 1 isoform X3

    Conserved Domains (4) summary
    cd13285
    Location:152 → 275
    PH_ORP1; Human Oxysterol binding protein related protein 1 Pleckstrin homology (PH) domain
    sd00045
    Location:43 → 78
    ANK; ANK repeat [structural motif]
    pfam01237
    Location:471 → 863
    Oxysterol_BP; Oxysterol-binding protein
    pfam12796
    Location:10 → 111
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_006526143.4 → XP_006526206.1  oxysterol-binding protein-related protein 1 isoform X2

    Conserved Domains (5) summary
    COG0666
    Location:38 → 208
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:43 → 78
    ANK; ANK repeat [structural motif]
    pfam01237
    Location:507 → 899
    Oxysterol_BP; Oxysterol-binding protein
    pfam12796
    Location:10 → 111
    Ank_2; Ankyrin repeats (3 copies)
    cl17171
    Location:229 → 324
    PH-like; Pleckstrin homology-like domain

  3. XM_006526141.5 → XP_006526204.1  oxysterol-binding protein-related protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006526204.1

    UniProtKB/Swiss-Prot
    O88318, Q3TH97, Q673L8, Q6DFU6, Q91XL9
    Conserved Domains (5) summary
    COG0666
    Location:38 → 208
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd13285
    Location:229 → 352
    PH_ORP1; Human Oxysterol binding protein related protein 1 Pleckstrin homology (PH) domain
    sd00045
    Location:43 → 78
    ANK; ANK repeat [structural motif]
    pfam01237
    Location:548 → 940
    Oxysterol_BP; Oxysterol-binding protein
    pfam12796
    Location:10 → 111
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_036161233.1 → XP_036017126.1  oxysterol-binding protein-related protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A3Q4EI24
    Conserved Domains (1) summary
    pfam01237
    Location:192 → 584
    Oxysterol_BP; Oxysterol-binding protein

  5. XM_030250565.2 → XP_030106425.1  oxysterol-binding protein-related protein 1 isoform X7

    UniProtKB/TrEMBL
    Q3UZK3
    Conserved Domains (1) summary
    pfam01237
    Location:35 → 427
    Oxysterol_BP; Oxysterol-binding protein

  6. XM_017317960.2 → XP_017173449.1  oxysterol-binding protein-related protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A3Q4EI24
    Conserved Domains (1) summary
    pfam01237
    Location:192 → 584
    Oxysterol_BP; Oxysterol-binding protein

  7. XM_030250567.1 → XP_030106427.1  oxysterol-binding protein-related protein 1 isoform X7

    UniProtKB/TrEMBL
    Q3UZK3
    Conserved Domains (1) summary
    pfam01237
    Location:35 → 427
    Oxysterol_BP; Oxysterol-binding protein

  8. XM_006526148.3 → XP_006526211.1  oxysterol-binding protein-related protein 1 isoform X7

    See identical proteins and their annotated locations for XP_006526211.1

    UniProtKB/TrEMBL
    Q3UZK3
    Conserved Domains (1) summary
    pfam01237
    Location:35 → 427
    Oxysterol_BP; Oxysterol-binding protein

  9. XM_017317962.2 → XP_017173451.1  oxysterol-binding protein-related protein 1 isoform X7

    UniProtKB/TrEMBL
    Q3UZK3
    Related
    ENSMUSP00000157342.2, ENSMUST00000234871.2
    Conserved Domains (1) summary
    pfam01237
    Location:35 → 427
    Oxysterol_BP; Oxysterol-binding protein

  10. XM_017317963.2 → XP_017173452.1  oxysterol-binding protein-related protein 1 isoform X7

    UniProtKB/TrEMBL
    Q3UZK3
    Conserved Domains (1) summary
    pfam01237
    Location:35 → 427
    Oxysterol_BP; Oxysterol-binding protein

  11. XM_036161236.1 → XP_036017129.1  oxysterol-binding protein-related protein 1 isoform X8

    UniProtKB/TrEMBL
    Q3UZK3
    Conserved Domains (1) summary
    pfam01237
    Location:8 → 400
    Oxysterol_BP; Oxysterol-binding protein

  12. XM_030250568.1 → XP_030106428.1  oxysterol-binding protein-related protein 1 isoform X8

    UniProtKB/TrEMBL
    Q3UZK3
    Related
    ENSMUSP00000113268.2, ENSMUST00000121774.8
    Conserved Domains (1) summary
    pfam01237
    Location:8 → 400
    Oxysterol_BP; Oxysterol-binding protein

  13. XM_036161235.1 → XP_036017128.1  oxysterol-binding protein-related protein 1 isoform X8

    UniProtKB/TrEMBL
    Q3UZK3
    Conserved Domains (1) summary
    pfam01237
    Location:8 → 400
    Oxysterol_BP; Oxysterol-binding protein

  14. XM_017317961.2 → XP_017173450.1  oxysterol-binding protein-related protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A3Q4EI24
    Related
    ENSMUSP00000157209.2, ENSMUST00000235027.2
    Conserved Domains (1) summary
    pfam01237
    Location:156 → 548
    Oxysterol_BP; Oxysterol-binding protein

  15. XM_006526147.3 → XP_006526210.1  oxysterol-binding protein-related protein 1 isoform X7

    See identical proteins and their annotated locations for XP_006526210.1

    UniProtKB/TrEMBL
    Q3UZK3
    Conserved Domains (1) summary
    pfam01237
    Location:35 → 427
    Oxysterol_BP; Oxysterol-binding protein

  16. XM_030250564.2 → XP_030106424.1  oxysterol-binding protein-related protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A3Q4EG54, A0A3Q4EI24
    Related
    ENSMUSP00000157020.2, ENSMUST00000234118.2
    Conserved Domains (1) summary
    pfam01237
    Location:126 → 518
    Oxysterol_BP; Oxysterol-binding protein

  17. XM_036161237.1 → XP_036017130.1  oxysterol-binding protein-related protein 1 isoform X8

    UniProtKB/TrEMBL
    Q3UZK3
    Conserved Domains (1) summary
    pfam01237
    Location:8 → 400
    Oxysterol_BP; Oxysterol-binding protein

  18. XM_006526142.4 → XP_006526205.1  oxysterol-binding protein-related protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006526205.1

    UniProtKB/Swiss-Prot
    O88318, Q3TH97, Q673L8, Q6DFU6, Q91XL9
    Conserved Domains (5) summary
    COG0666
    Location:38 → 208
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd13285
    Location:229 → 352
    PH_ORP1; Human Oxysterol binding protein related protein 1 Pleckstrin homology (PH) domain
    sd00045
    Location:43 → 78
    ANK; ANK repeat [structural motif]
    pfam01237
    Location:548 → 940
    Oxysterol_BP; Oxysterol-binding protein
    pfam12796
    Location:10 → 111
    Ank_2; Ankyrin repeats (3 copies)

  19. XM_030250566.2 → XP_030106426.1  oxysterol-binding protein-related protein 1 isoform X7

    UniProtKB/TrEMBL
    Q3UZK3
    Conserved Domains (1) summary
    pfam01237
    Location:35 → 427
    Oxysterol_BP; Oxysterol-binding protein

  20. XM_017317965.1 → XP_017173454.1  oxysterol-binding protein-related protein 1 isoform X7

    UniProtKB/TrEMBL
    Q3UZK3
    Conserved Domains (1) summary
    pfam01237
    Location:35 → 427
    Oxysterol_BP; Oxysterol-binding protein

  21. XM_036161238.1 → XP_036017131.1  oxysterol-binding protein-related protein 1 isoform X8

    UniProtKB/TrEMBL
    Q3UZK3
    Conserved Domains (1) summary
    pfam01237
    Location:8 → 400
    Oxysterol_BP; Oxysterol-binding protein

  22. XM_017317964.1 → XP_017173453.1  oxysterol-binding protein-related protein 1 isoform X7

    UniProtKB/TrEMBL
    Q3UZK3
    Conserved Domains (1) summary
    pfam01237
    Location:35 → 427
    Oxysterol_BP; Oxysterol-binding protein

RNA

  1. XR_004939876.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_020573.1: Suppressed sequence

    Description
    NM_020573.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91XL9.2 GenPept UniProtKB/Swiss-Prot:Q91XL9

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