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Ngb neuroglobin [ Mus musculus (house mouse) ]

Gene ID: 64242, updated on 21-Apr-2024

Summary

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Official Symbol
Ngbprovided by MGI
Official Full Name
neuroglobinprovided by MGI
Primary source
MGI:MGI:2151886
See related
Ensembl:ENSMUSG00000021032 AllianceGenome:MGI:2151886
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables oxygen carrier activity. Acts upstream of or within oxygen transport. Predicted to be located in mitochondrion; neuron projection; and perikaryon. Is expressed in brain; future brain; retina; and testis. Orthologous to human NGB (neuroglobin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 22.2), stomach adult (RPKM 7.1) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 D2; 12 41.29 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (87144305..87149313, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (87097531..87102539, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene zinc finger, DHHC-type containing 22 Neighboring gene transmembrane protein 63c Neighboring gene crumbs homolog 1 pseudogene Neighboring gene protein-O-mannosyltransferase 2 Neighboring gene STARR-positive B cell enhancer ABC_E10770 Neighboring gene STARR-positive B cell enhancer ABC_E10771 Neighboring gene glutathione transferase zeta 1 (maleylacetoacetate isomerase) Neighboring gene predicted gene 6566 Neighboring gene transmembrane p24 trafficking protein 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Neuroglobin deficiency increases seizure susceptibility but does not affect basal behavior in mice. Gøtzsche CR, et al. J Neurosci Res, 2022 Oct. PMID 35822521, Free PMC Article
  2. Probing the Role of Murine Neuroglobin CDloop-D-Helix Unit in CO Ligand Binding and Structural Dynamics. Exertier C, et al. ACS Chem Biol, 2022 Aug 19. PMID 35797699, Free PMC Article
  3. Lack of orientation selectivity of the heme insertion in murine neuroglobin revealed by resonance Raman spectroscopy. Milazzo L, et al. FEBS J, 2020 Sep. PMID 32034988
  4. Non-Methylation-Linked Mechanism of REST-Induced Neuroglobin Expression Impacts Mitochondrial Phenotypes in a Mouse Model of Amyotrophic Lateral Sclerosis. Van Acker ZP, et al. Neuroscience, 2019 Aug 1. PMID 31158439
  5. Localization of neuroglobin in the brain of R6/2 mouse model of Huntington's disease. Cardinale A, et al. Neurol Sci, 2018 Feb. PMID 29101592

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neuroglobin deficiency increases seizure susceptibility but does not affect basal behavior in mice.
    Title: Neuroglobin deficiency increases seizure susceptibility but does not affect basal behavior in mice.
  2. Probing the Role of Murine Neuroglobin CDloop-D-Helix Unit in CO Ligand Binding and Structural Dynamics.
    Title: Probing the Role of Murine Neuroglobin CDloop-D-Helix Unit in CO Ligand Binding and Structural Dynamics.
  3. Lack of orientation selectivity of the heme insertion in murine neuroglobin revealed by resonance Raman spectroscopy.
    Title: Lack of orientation selectivity of the heme insertion in murine neuroglobin revealed by resonance Raman spectroscopy.
  4. A neuroglobin-based high-affinity ligand trap reverses carbon monoxide-induced mitochondrial poisoning.
    Title: A neuroglobin-based high-affinity ligand trap reverses carbon monoxide-induced mitochondrial poisoning.
  5. These results indicate Ngb to be involved in and affected by the SOD1(G93A) pathology, which could in part be attributed to its role in halting destabilizing events of mitochondrial swelling and phenotypes.
    Title: Non-Methylation-Linked Mechanism of REST-Induced Neuroglobin Expression Impacts Mitochondrial Phenotypes in a Mouse Model of Amyotrophic Lateral Sclerosis.
  6. Ngb promotes axon regeneration via oxygen-Ngb-p38-GAP43 signaling during ischemia/reperfusion.
    Title: Neuroglobin boosts axon regeneration during ischemic reperfusion via p38 binding and activation depending on oxygen signal.
  7. This is the first report demonstrating a similar pattern of Ngb expression during disease progression in the brains of R6/2 mice.
    Title: Localization of neuroglobin in the brain of R6/2 mouse model of Huntington's disease.
  8. NGB proved to act cytoprotectively during MI in the acute setting while this effect was less pronounced in the atherosclerosis model.
    Title: Cytoprotective effects of transgenic neuroglobin overexpression in an acute and chronic mouse model of ischemic heart disease.
  9. Study showed that in Neuroglobin (Ngb) knockout mice, distortion-product otoacoustic emissions thresholds were moderately augmented in the range of 5-18kHz. Results suggest that the lack of NgB, results in only marginal deficits in hearing ability.
    Title: Hearing Without Neuroglobin.
  10. Ngb-H64Q-CCC binds CO about 500 times more strongly than hemoglobin, which could be useful in detecting and eliminating carbon monoxide poisoning
    Title: Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning.
Submit: New GeneRIF Correction See all GeneRIFs (69)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP-dissociation inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nitrite reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxygen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxygen binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxygen binding ISO
Inferred from Sequence Orthology
more info
  
enables oxygen carrier activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxygen carrier activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in oxygen transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within oxygen transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
neuroglobin
Names
nitrite reductase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001294308.1 → NP_001281237.1  neuroglobin isoform 1

    See identical proteins and their annotated locations for NP_001281237.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC132609, AW489131
    Consensus CDS
    CCDS79141.1
    UniProtKB/TrEMBL
    Q3USR6
    Related
    ENSMUSP00000105806.3, ENSMUST00000110177.9
    Conserved Domains (1) summary
    cd08920
    Location:1 → 152
    Ngb; Neuroglobins

  2. NM_022414.2 → NP_071859.1  neuroglobin isoform 2

    See identical proteins and their annotated locations for NP_071859.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    BC024263
    Consensus CDS
    CCDS36501.1
    UniProtKB/Swiss-Prot
    Q9ER97
    UniProtKB/TrEMBL
    Q5ZPR7
    Related
    ENSMUSP00000021420.8, ENSMUST00000021420.14
    Conserved Domains (1) summary
    cd08920
    Location:1 → 148
    Ngb; Neuroglobins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    87144305..87149313 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ER97.1 GenPept UniProtKB/Swiss-Prot:Q9ER97

Gene LinkOut

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