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Rgs18 regulator of G-protein signaling 18 [ Mus musculus (house mouse) ]

Gene ID: 64214, updated on 5-Mar-2024

Summary

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Official Symbol
Rgs18provided by MGI
Official Full Name
regulator of G-protein signaling 18provided by MGI
Primary source
MGI:MGI:1927498
See related
Ensembl:ENSMUSG00000026357 AllianceGenome:MGI:1927498
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables GTPase activator activity. Acts upstream of or within G protein-coupled receptor signaling pathway and regulation of G protein-coupled receptor signaling pathway. Located in cytoplasm. Is expressed in liver. Orthologous to human RGS18 (regulator of G protein signaling 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 3.7), liver E18 (RPKM 2.8) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Rgs18 in Genome Data Viewer
Location:
1 F; 1 62.99 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (144628430..144651165, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (144752683..144775427, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02538 Neighboring gene STARR-positive B cell enhancer ABC_E5816 Neighboring gene predicted gene 7266 Neighboring gene STARR-seq mESC enhancer starr_02539 Neighboring gene regulator of G-protein signalling 21 Neighboring gene STARR-seq mESC enhancer starr_02540 Neighboring gene STARR-seq mESC enhancer starr_02541 Neighboring gene predicted gene, 22681 Neighboring gene cytokine receptor-like factor 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The regulator of G-protein signaling 18 regulates platelet aggregation, hemostasis and thrombosis. Alshbool FZ, et al. Biochem Biophys Res Commun, 2015 Jul 10. PMID 25969426
  2. Regulator of G-protein signaling 18 controls both platelet generation and function. Delesque-Touchard N, et al. PLoS One, 2014. PMID 25405900, Free PMC Article
  3. RGS10 and RGS18 differentially limit platelet activation, promote platelet production, and prolong platelet survival. DeHelian D, et al. Blood, 2020 Oct 8. PMID 32542378, Free PMC Article
  4. Reciprocal regulation of alternative lineages by Rgs18 and its transcriptional repressor Gfi1b. Sengupta A, et al. J Cell Sci, 2016 Jan 1. PMID 26567214, Free PMC Article
  5. Modulating platelet reactivity through control of RGS18 availability. Ma P, et al. Blood, 2015 Dec 10. PMID 26407691, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A regulatory node involving Galphaq, PLCbeta, and RGS proteins modulates platelet reactivity to critical agonists.
    Title: A regulatory node involving Gα(q), PLCβ, and RGS proteins modulates platelet reactivity to critical agonists.
  2. RGS10 and RGS18 differentially limit platelet activation, promote platelet production, and prolong platelet survival.
    Title: RGS10 and RGS18 differentially limit platelet activation, promote platelet production, and prolong platelet survival.
  3. these results identify Rgs18 as a new and crucial effector of Gfi1b that regulates downstream signaling and gene expression programs to orchestrate erythro-megakaryocytic lineage choices.
    Title: Reciprocal regulation of alternative lineages by Rgs18 and its transcriptional repressor Gfi1b.
  4. Regulator of G-protein signaling 18 controls both platelet generation and function.
    Title: Regulator of G-protein signaling 18 controls both platelet generation and function.
  5. Regulated sequestration and release of RGS18 by intracellular binding proteins coordinates activating and inhibitory signaling networks in platelets. Substituting alanine for Ser94 blocks cAMP-induced dissociation of the SPL/RGS/SHP-1 complex.
    Title: Modulating platelet reactivity through control of RGS18 availability.
  6. RGS18 deficiency markedly shortened bleeding as well as occlusion times (in vivo). Furthermore, RGS18(-/-) platelets displayed hyper-responsiveness with regards to agonist induced aggregation
    Title: The regulator of G-protein signaling 18 regulates platelet aggregation, hemostasis and thrombosis.
  7. study is the first to show that RGS18 regulates megakaryopoiesis but also reveals its unexpected role in ciliogenesis, at least in lower vertebrates, via interference with Wnt signaling.
    Title: Regulator of G-protein signaling 18 controls megakaryopoiesis and the cilia-mediated vertebrate mechanosensory system.
  8. RGS18 acts as a negative regulator of the acidosis-induced osteoclastogenic protein-coupled receptor 68/NFAT signaling pathway
    Title: RGS18 acts as a negative regulator of osteoclastogenesis by modulating the acid-sensing OGR1/NFAT signaling pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC117531

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
regulator of G-protein signaling 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412709.1 → NP_001399638.1  regulator of G-protein signaling 18 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC102163

  2. NM_022881.6 → NP_075019.1  regulator of G-protein signaling 18 isoform 1

    See identical proteins and their annotated locations for NP_075019.1

    Status: VALIDATED

    Source sequence(s)
    AC102163
    Consensus CDS
    CCDS15350.1
    UniProtKB/Swiss-Prot
    Q99PG4
    UniProtKB/TrEMBL
    Q544K2
    Related
    ENSMUSP00000027603.4, ENSMUST00000027603.4
    Conserved Domains (1) summary
    cl02565
    Location:87 → 199
    RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    144628430..144651165 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99PG4.1 GenPept UniProtKB/Swiss-Prot:Q99PG4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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