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St7 suppression of tumorigenicity 7 [ Mus musculus (house mouse) ]

Gene ID: 64213, updated on 5-Mar-2024

Summary

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Official Symbol
St7provided by MGI
Official Full Name
suppression of tumorigenicity 7provided by MGI
Primary source
MGI:MGI:1927450
See related
Ensembl:ENSMUSG00000029534 AllianceGenome:MGI:1927450
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HELG; RAY1; SEN4; TSG7; Fam4a2; 9430001H04Rik
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in brain; early conceptus; secondary oocyte; and spinal cord. Orthologous to human ST7 (suppression of tumorigenicity 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 8.2), whole brain E14.5 (RPKM 7.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 A2; 6 8.0 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (17693579..17943022)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (17693901..17943023)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15256 Neighboring gene predicted gene, 53318 Neighboring gene STARR-positive B cell enhancer ABC_E9662 Neighboring gene capping actin protein of muscle Z-line subunit alpha 2 Neighboring gene STARR-positive B cell enhancer mm9_chr6:17682030-17682331 Neighboring gene four and a half LIM domains 3 pseudogene Neighboring gene metal response element binding transcription factor 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_15259 Neighboring gene STARR-positive B cell enhancer mm9_chr6:17726341-17726642 Neighboring gene predicted gene, 52895 Neighboring gene STARR-seq mESC enhancer starr_15260 Neighboring gene STARR-seq mESC enhancer starr_15261 Neighboring gene STARR-seq mESC enhancer starr_15263 Neighboring gene wingless-type MMTV integration site family, member 2 Neighboring gene ankyrin repeat, SAM and basic leucine zipper domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of mouse St7r (St7-like, St7l). Saitoh T, et al. Int J Mol Med, 2002 Jul. PMID 12060862
  2. Identification of a novel gene on chromosome 7q31 that is interrupted by a translocation breakpoint in an autistic individual. Vincent JB, et al. Am J Hum Genet, 2000 Aug. PMID 10889047, Free PMC Article
  3. Assessment of F-MuLV-induced tumorigenesis reveals new candidate tumor genes including Pecam1, St7, and Prim2. Yatsula B, et al. Leukemia, 2006 Jan. PMID 16307020
  4. Met proto-oncogene juxtamembrane rare variations in mouse and humans: differential effects of Arg and Cys alleles on mouse lung tumorigenesis. Zaffaroni D, et al. Oncogene, 2005 Feb 3. PMID 15592501
  5. Mutational and functional analyses reveal that ST7 is a highly conserved tumor-suppressor gene on human chromosome 7q31. Zenklusen JC, et al. Nat Genet, 2001 Apr. PMID 11279520

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. suppressor of tumorigenicity 7 (ST7) and nonmetastatic 23 (NM23) are direct targets of PRMT5-containing BRG1 and hBRM complexes
    Title: Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC118540

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
suppressor of tumorigenicity 7 protein
Names
4low density lipoprotein-related protein 12
family with sequence similarity 4, subfamily A, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083315.2 → NP_001076784.1  suppressor of tumorigenicity 7 protein isoform 2

    See identical proteins and their annotated locations for NP_001076784.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC068561, AK079107, AK132103
    Consensus CDS
    CCDS39431.1
    UniProtKB/TrEMBL
    D3YUM7
    Related
    ENSMUSP00000111077.4, ENSMUST00000115417.4
    Conserved Domains (1) summary
    cd11557
    Location:11 → 475
    ST7; Suppression of tumorigenicity 7

  2. NM_001289624.1 → NP_001276553.1  suppressor of tumorigenicity 7 protein isoform 3

    See identical proteins and their annotated locations for NP_001276553.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AC068561, AC153836
    Consensus CDS
    CCDS71728.1
    UniProtKB/Swiss-Prot
    Q3UA20, Q6Q9W2, Q6Q9W3, Q8R3T3, Q921F6, Q99M89, Q99M90, Q99M91, Q99M92, Q99M93, Q99M94, Q99M96, Q9JID7, Q9JID8
    UniProtKB/TrEMBL
    D3YUM7
    Related
    ENSMUSP00000080341.7, ENSMUST00000081635.13
    Conserved Domains (1) summary
    pfam04184
    Location:19 → 576
    ST7; ST7 protein

  3. NM_001289625.1 → NP_001276554.1  suppressor of tumorigenicity 7 protein isoform 4

    See identical proteins and their annotated locations for NP_001276554.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, uses an alternate in-frame splice site, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AC068561, AC153836
    Consensus CDS
    CCDS80490.1
    UniProtKB/TrEMBL
    D3YUM7
    Related
    ENSMUSP00000111079.2, ENSMUST00000115419.8
    Conserved Domains (1) summary
    pfam04184
    Location:19 → 571
    ST7; ST7 protein

  4. NM_001289626.1 → NP_001276555.1  suppressor of tumorigenicity 7 protein isoform 5

    See identical proteins and their annotated locations for NP_001276555.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and lacks an alternate in-frame exon, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (5) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AC068561, AC153836
    Consensus CDS
    CCDS71729.1
    UniProtKB/TrEMBL
    D3YUM7, Q99M95
    Related
    ENSMUSP00000062886.6, ENSMUST00000052113.12
    Conserved Domains (1) summary
    pfam04184
    Location:19 → 553
    ST7; ST7 protein

  5. NM_001289627.1 → NP_001276556.1  suppressor of tumorigenicity 7 protein isoform 6

    See identical proteins and their annotated locations for NP_001276556.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (6) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC068561, AC153836
    Consensus CDS
    CCDS71730.1
    UniProtKB/TrEMBL
    D3YUM7
    Related
    ENSMUSP00000076334.3, ENSMUST00000077080.9
    Conserved Domains (1) summary
    pfam04184
    Location:4 → 530
    ST7; ST7 protein

  6. NM_001289629.1 → NP_001276558.1  suppressor of tumorigenicity 7 protein isoform 7

    See identical proteins and their annotated locations for NP_001276558.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region and lacks an alternate in-frame exon, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (7) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC068561, AC153836
    Consensus CDS
    CCDS71731.1
    UniProtKB/TrEMBL
    D3YUM7
    Related
    ENSMUSP00000000674.7, ENSMUST00000000674.13
    Conserved Domains (1) summary
    pfam04184
    Location:4 → 507
    ST7; ST7 protein

  7. NM_022332.3 → NP_071727.2  suppressor of tumorigenicity 7 protein isoform 1

    See identical proteins and their annotated locations for NP_071727.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AK079107, BC108418, BY479263
    Consensus CDS
    CCDS19927.1
    UniProtKB/TrEMBL
    D3YUM7
    Related
    ENSMUSP00000057326.8, ENSMUST00000053148.14
    Conserved Domains (1) summary
    cd11557
    Location:11 → 498
    ST7; Suppression of tumorigenicity 7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    17693579..17943022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241076.4 → XP_011239378.1  suppressor of tumorigenicity 7 protein isoform X1

    Conserved Domains (1) summary
    cd11557
    Location:1 → 377
    ST7; Suppression of tumorigenicity 7

RNA

  1. XR_004933617.1 RNA Sequence

  2. XR_868763.4 RNA Sequence

  3. XR_868764.4 RNA Sequence

  4. XR_003956242.2 RNA Sequence

  5. XR_377290.5 RNA Sequence

  6. XR_003956244.2 RNA Sequence

  7. XR_003956243.2 RNA Sequence

  8. XR_377291.5 RNA Sequence

  9. XR_003956245.2 RNA Sequence

  10. XR_003956246.2 RNA Sequence

  11. XR_003956247.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99M96.1 GenPept UniProtKB/Swiss-Prot:Q99M96

Gene LinkOut

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