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Sv2b synaptic vesicle glycoprotein 2b [ Mus musculus (house mouse) ]

Gene ID: 64176, updated on 8-May-2024

Summary

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Official Symbol
Sv2bprovided by MGI
Official Full Name
synaptic vesicle glycoprotein 2bprovided by MGI
Primary source
MGI:MGI:1927338
See related
Ensembl:ENSMUSG00000053025 AllianceGenome:MGI:1927338
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0735; A830038F04Rik
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to act upstream of or within chemical synaptic transmission. Located in synaptic vesicle. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SV2B (synaptic vesicle glycoprotein 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 34.7), frontal lobe adult (RPKM 26.9) and 2 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 D1; 7 43.62 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (74764642..74959143, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (75114894..75309262, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19211 Neighboring gene predicted gene, 53361 Neighboring gene STARR-seq mESC enhancer starr_19212 Neighboring gene RIKEN cDNA 4930533N22 gene Neighboring gene STARR-seq mESC enhancer starr_19213 Neighboring gene STARR-seq mESC enhancer starr_19214 Neighboring gene STARR-positive B cell enhancer ABC_E11357 Neighboring gene STARR-seq mESC enhancer starr_19215 Neighboring gene RIKEN cDNA 1500012K07 gene Neighboring gene STARR-positive B cell enhancer mm9_chr7:82463213-82463514 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:82507527-82507739 Neighboring gene STARR-positive B cell enhancer mm9_chr7:82515952-82516252 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:82516993-82517187 Neighboring gene STARR-positive B cell enhancer mm9_chr7:82532718-82533019 Neighboring gene STARR-positive B cell enhancer mm9_chr7:82533022-82533322 Neighboring gene ribosomal protein S28 pseudogene Neighboring gene predicted gene, 46017

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Synaptic Vesicle Protein 2B Negatively Regulates the Amyloidogenic Processing of AβPP as a Novel Interaction Partner of BACE1. Miyamoto M, et al. J Alzheimers Dis, 2020. PMID 32280101
  2. Lack of synaptic vesicle protein SV2B protects against amyloid-β₂₅₋₃₅-induced oxidative stress, cholinergic deficit and cognitive impairment in mice. Detrait E, et al. Behav Brain Res, 2014 Sep 1. PMID 24937053
  3. SV2 acts via presynaptic calcium to regulate neurotransmitter release. Wan QF, et al. Neuron, 2010 Jun 24. PMID 20620874, Free PMC Article
  4. Loss of the Synaptic Vesicle Protein SV2B results in reduced neurotransmission and altered synaptic vesicle protein expression in the retina. Morgans CW, et al. PLoS One, 2009. PMID 19381277, Free PMC Article
  5. Altered balance between excitatory and inhibitory inputs onto CA1 pyramidal neurons from SV2A-deficient but not SV2B-deficient mice. Venkatesan K, et al. J Neurosci Res, 2012 Dec. PMID 22847229

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Synaptic Vesicle Protein 2B Negatively Regulates the Amyloidogenic Processing of AbetaPP as a Novel Interaction Partner of BACE1.
    Title: Synaptic Vesicle Protein 2B Negatively Regulates the Amyloidogenic Processing of AβPP as a Novel Interaction Partner of BACE1.
  2. To study the role of SV2B in maintaining the podocyte function and to better understand the function of the neuron-like vesicle expressing SV2B in the podocyte, we analyzed them with SV2B knockout (KO) mice.
    Title: SV2B is essential for the integrity of the glomerular filtration barrier.
  3. Glutamatergic & GABAergic transmission are unaffected by deletion of the SV2B protein. Additional deletion of SV2B does not affect the electrophysiological phenotype of SV2A deletion.
    Title: Altered balance between excitatory and inhibitory inputs onto CA1 pyramidal neurons from SV2A-deficient but not SV2B-deficient mice.
  4. Loss of synaptic vesicle glycoprotein 2b is associated with inhibition of tetanus neurotoxin into central neurons.
    Title: SV2 mediates entry of tetanus neurotoxin into central neurons.
  5. These results indicate that SV2 performs at least two actions at the synapse that contribute to neurotransmitter release.
    Title: SV2 regulates neurotransmitter release via multiple mechanisms.
  6. SV2 controls key aspects of synaptic functionality via its ability to regulate presynaptic Ca(2+).
    Title: SV2 acts via presynaptic calcium to regulate neurotransmitter release.
  7. SV2B contributes to the modulation of synaptic vesicle exocytosis and plays a significant role in regulating synaptic protein content
    Title: Loss of the Synaptic Vesicle Protein SV2B results in reduced neurotransmission and altered synaptic vesicle protein expression in the retina.
  8. Data demonstrate that glycosylated SV2A and SV2B act in conjunction with gangliosides to mediate the entry of BoNT/E into neurons.
    Title: Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons.
  9. SV2B-synaptotagmin 1 complex is involved in the regulation of synaptotagmin 1 stability and/or trafficking
    Title: SV2B regulates synaptotagmin 1 by direct interaction.
  10. findings show that botulinum neurotoxin (BoNT/A) enters neurons by binding to the synaptic vesicle protein SV2 (isoforms A, B, and C);SV2 acts as the protein receptor for BoNT/A
    Title: SV2 is the protein receptor for botulinum neurotoxin A.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC38746

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chemical synaptic transmission TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of presynaptic cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of presynaptic cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
synaptic vesicle glycoprotein 2B
Names
synaptic vesicle glycoprotein 2 b
synaptic vesicle protein 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109753.1 → NP_001103223.1  synaptic vesicle glycoprotein 2B

    See identical proteins and their annotated locations for NP_001103223.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. All seven variants encode the same protein.
    Source sequence(s)
    AK043830, AK147261, BC060224, BY269935
    Consensus CDS
    CCDS21368.1
    UniProtKB/Swiss-Prot
    Q80TT1, Q8BG39, Q9ES95
    Related
    ENSMUSP00000082254.6, ENSMUST00000085164.7
    Conserved Domains (1) summary
    TIGR01299
    Location:8 → 683
    synapt_SV2; synaptic vesicle protein SV2

  2. NM_001360571.1 → NP_001347500.1  synaptic vesicle glycoprotein 2B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. All seven variants encode the same protein.
    Source sequence(s)
    AC113471, AC116898, AC127355
    Consensus CDS
    CCDS21368.1
    UniProtKB/Swiss-Prot
    Q80TT1, Q8BG39, Q9ES95
    Conserved Domains (1) summary
    TIGR01299
    Location:8 → 683
    synapt_SV2; synaptic vesicle protein SV2

  3. NM_001360572.1 → NP_001347501.1  synaptic vesicle glycoprotein 2B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. All seven variants encode the same protein.
    Source sequence(s)
    AC113471, AC116898, AC127355
    Consensus CDS
    CCDS21368.1
    UniProtKB/Swiss-Prot
    Q80TT1, Q8BG39, Q9ES95
    Conserved Domains (1) summary
    TIGR01299
    Location:8 → 683
    synapt_SV2; synaptic vesicle protein SV2

  4. NM_001360573.1 → NP_001347502.1  synaptic vesicle glycoprotein 2B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. All seven variants encode the same protein.
    Source sequence(s)
    AC113471, AC116898, AC127355
    Consensus CDS
    CCDS21368.1
    UniProtKB/Swiss-Prot
    Q80TT1, Q8BG39, Q9ES95
    Conserved Domains (1) summary
    TIGR01299
    Location:8 → 683
    synapt_SV2; synaptic vesicle protein SV2

  5. NM_001360574.1 → NP_001347503.1  synaptic vesicle glycoprotein 2B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 3. All seven variants encode the same protein.
    Source sequence(s)
    AC113471, AC116898, AC127355
    Consensus CDS
    CCDS21368.1
    UniProtKB/Swiss-Prot
    Q80TT1, Q8BG39, Q9ES95
    Conserved Domains (1) summary
    TIGR01299
    Location:8 → 683
    synapt_SV2; synaptic vesicle protein SV2

  6. NM_001360575.1 → NP_001347504.1  synaptic vesicle glycoprotein 2B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 3. All seven variants encode the same protein.
    Source sequence(s)
    AC116898, AK029736, BC060224
    Consensus CDS
    CCDS21368.1
    UniProtKB/Swiss-Prot
    Q80TT1, Q8BG39, Q9ES95
    Related
    ENSMUSP00000146049.2, ENSMUST00000206344.2
    Conserved Domains (1) summary
    TIGR01299
    Location:8 → 683
    synapt_SV2; synaptic vesicle protein SV2

  7. NM_153579.4 → NP_705807.2  synaptic vesicle glycoprotein 2B

    See identical proteins and their annotated locations for NP_705807.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. All seven variants encode the same protein.
    Source sequence(s)
    BC060224, BC079568
    Consensus CDS
    CCDS21368.1
    UniProtKB/Swiss-Prot
    Q80TT1, Q8BG39, Q9ES95
    Related
    ENSMUSP00000127245.2, ENSMUST00000165175.8
    Conserved Domains (1) summary
    TIGR01299
    Location:8 → 683
    synapt_SV2; synaptic vesicle protein SV2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    74764642..74959143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153323.1 → XP_036009216.1  synaptic vesicle glycoprotein 2B isoform X1

    UniProtKB/Swiss-Prot
    Q80TT1, Q8BG39, Q9ES95
    Conserved Domains (1) summary
    TIGR01299
    Location:8 → 683
    synapt_SV2; synaptic vesicle protein SV2

  2. XM_036153324.1 → XP_036009217.1  synaptic vesicle glycoprotein 2B isoform X1

    UniProtKB/Swiss-Prot
    Q80TT1, Q8BG39, Q9ES95
    Conserved Domains (1) summary
    TIGR01299
    Location:8 → 683
    synapt_SV2; synaptic vesicle protein SV2

  3. XM_006541059.4 → XP_006541122.1  synaptic vesicle glycoprotein 2B isoform X1

    See identical proteins and their annotated locations for XP_006541122.1

    UniProtKB/Swiss-Prot
    Q80TT1, Q8BG39, Q9ES95
    Conserved Domains (1) summary
    TIGR01299
    Location:8 → 683
    synapt_SV2; synaptic vesicle protein SV2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BG39.1 GenPept UniProtKB/Swiss-Prot:Q8BG39

Gene LinkOut

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