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NECAB1 N-terminal EF-hand calcium binding protein 1 [ Homo sapiens (human) ]

Gene ID: 64168, updated on 5-Mar-2024

Summary

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Official Symbol
NECAB1provided by HGNC
Official Full Name
N-terminal EF-hand calcium binding protein 1provided by HGNC
Primary source
HGNC:HGNC:20983
See related
Ensembl:ENSG00000123119 AllianceGenome:HGNC:20983
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EFCBP1; STIP-1
Summary
Enables identical protein binding activity. Predicted to be involved in regulation of amyloid precursor protein biosynthetic process. Predicted to act upstream of or within blastocyst hatching. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 31.1), testis (RPKM 8.9) and 12 other tissues See more
Orthologs
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Genomic context

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Location:
8q21.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (90791775..90959393)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (91916601..92084316)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (91804003..91971621)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27613 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19351 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19352 Neighboring gene translation initiation factor IF-2 Neighboring gene transmembrane protein 64 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:91678635-91679135 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:91695833-91696820 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:91696821-91697808 Neighboring gene uncharacterized LOC105375633 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:91713257-91713757 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:91712756-91713256 Neighboring gene uncharacterized LOC105375635 Neighboring gene uncharacterized LOC105375634 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19353 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19354 Neighboring gene chromosome 8 open reading frame 88 Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19355 Neighboring gene OTUD6B antisense RNA 1 (head to head)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. EFCBP1/NECAB1, a brain-specifically expressed gene with highest abundance in temporal lobe, encodes a protein containing EF-hand and antibiotic biosynthesis monooxygenase domains. Wu H, et al. DNA Seq, 2007 Feb. PMID 17364817
  2. Comparative anatomical distribution of neuronal calcium-binding protein (NECAB) 1 and -2 in rodent and human spinal cord. Zhang MD, et al. Brain Struct Funct, 2016 Sep. PMID 26843217
  3. NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern. Sugita S, et al. Neuroscience, 2002. PMID 12044471
  4. Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins. Tomkins JE, et al. Proteomics, 2018 May. PMID 29513927, Free PMC Article
  5. Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer's disease. Ulbrich S, et al. PLoS One, 2018. PMID 29791485, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in blastocyst hatching IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of amyloid precursor protein biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
N-terminal EF-hand calcium-binding protein 1
Names
EF-hand calcium-binding protein 1
neuronal calcium binding protein
neuronal calcium-binding protein 1
synaptotagmin interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022351.5 → NP_071746.1  N-terminal EF-hand calcium-binding protein 1

    See identical proteins and their annotated locations for NP_071746.1

    Status: VALIDATED

    Source sequence(s)
    AF414126
    Consensus CDS
    CCDS47889.1
    UniProtKB/Swiss-Prot
    Q6NUS7, Q8N987, Q96AZ7, Q9HBW8
    Related
    ENSP00000387380.2, ENST00000417640.7
    Conserved Domains (3) summary
    pfam03992
    Location:254 → 325
    ABM; Antibiotic biosynthesis monooxygenase
    pfam13499
    Location:33 → 89
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:31 → 87
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    90791775..90959393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517213.3 → XP_011515515.1  N-terminal EF-hand calcium-binding protein 1 isoform X1

    Conserved Domains (3) summary
    pfam03992
    Location:254 → 315
    ABM; Antibiotic biosynthesis monooxygenase
    pfam13499
    Location:33 → 89
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:31 → 87
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    91916601..92084316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360981.1 → XP_054216956.1  N-terminal EF-hand calcium-binding protein 1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N987.1 GenPept UniProtKB/Swiss-Prot:Q8N987

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