U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TMEM91 transmembrane protein 91 [ Homo sapiens (human) ]

Gene ID: 641649, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
TMEM91provided by HGNC
Official Full Name
transmembrane protein 91provided by HGNC
Primary source
HGNC:HGNC:32393
See related
Ensembl:ENSG00000142046 MIM:618294; AllianceGenome:HGNC:32393
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DSPC3; IFITMD6; SynDIG3
Summary
Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be integral component of membrane. Predicted to be active in intracellular membrane-bounded organelle and membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bone marrow (RPKM 6.3), testis (RPKM 5.0) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See TMEM91 in Genome Data Viewer
Location:
19q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (41363947..41384083)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (44184527..44205320)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41869852..41889988)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14674 Neighboring gene coiled-coil domain containing 97 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41825837-41826574 Neighboring gene Sharpr-MPRA regulatory regions 2264 and 10656 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:41828472-41828958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41829057-41829826 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41830597-41831366 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41831367-41832136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14675 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10658 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41833547-41834068 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14676 Neighboring gene transforming growth factor beta 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14677 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10660 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10661 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10662 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10663 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10664 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:41860203-41860704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14679 Neighboring gene B9 domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10665 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:41885758-41885931 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:41889835-41890334 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:41892254-41892432 Neighboring gene exosome component 5 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:41903234-41903906 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:41903907-41904578 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41912476-41913430 Neighboring gene branched chain keto acid dehydrogenase E1 subunit alpha Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:41913431-41914386 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14681

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The dispanins: a novel gene family of ancient origin that contains 14 human members. Sällman Almén M, et al. PLoS One, 2012. PMID 22363774, Free PMC Article
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Bailey SD, et al. Diabetes Care, 2010 Oct. PMID 20628086, Free PMC Article
  3. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121, Free PMC Article
  4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. Choudhury NR, et al. BMC Biol, 2017 Nov 8. PMID 29117863, Free PMC Article
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Potential readthrough

Included gene: BCKDHA

Homology

Clone Names

  • FLJ27310, FLJ45695

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
transmembrane protein 91
Names
dispanin subfamily C member 3
interferon induced transmembrane protein domain containing 6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042595.3 → NP_001036060.1  transmembrane protein 91 isoform b

    See identical proteins and their annotated locations for NP_001036060.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform b) is shorter and has a distinct C-terminus compared to isoform a. Variants 2 and 7 both encode the same isoform (b).
    Source sequence(s)
    AI214374, AI277187, BC063705, BG697182
    Consensus CDS
    CCDS42572.1
    UniProtKB/TrEMBL
    F8W6Q6
    Related
    ENSP00000348750.4, ENST00000356385.8
    Conserved Domains (1) summary
    pfam04505
    Location:92 → 120
    CD225; Interferon-induced transmembrane protein

  2. NM_001098821.2 → NP_001092291.1  transmembrane protein 91 isoform a

    See identical proteins and their annotated locations for NP_001092291.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform a).
    Source sequence(s)
    AI214374, AK130820, DA673235
    Consensus CDS
    CCDS42571.1
    UniProtKB/Swiss-Prot
    C9J9D1, C9JZ62, C9K046, Q6P434, Q6ZNR0
    Related
    ENSP00000375859.1, ENST00000392002.7
    Conserved Domains (1) summary
    pfam04505
    Location:92 → 157
    CD225; Interferon-induced transmembrane protein

  3. NM_001098822.2 → NP_001092292.1  transmembrane protein 91 isoform c

    See identical proteins and their annotated locations for NP_001092292.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform c) is shorter and has a distinct C-terminus compared to isoform a. Variants 3, 6, and 8 all encode the same isoform (c).
    Source sequence(s)
    BX090160, DA673235, R67551
    Consensus CDS
    CCDS46082.1
    UniProtKB/TrEMBL
    F8W6Q6
    Related
    ENSP00000437779.1, ENST00000544232.5
    Conserved Domains (1) summary
    pfam04505
    Location:92 → 124
    CD225; Interferon-induced transmembrane protein

  4. NM_001098823.2 → NP_001092293.1  transmembrane protein 91 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform d) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AI214374, BF684543, DA673235
    Consensus CDS
    CCDS46083.1
    UniProtKB/TrEMBL
    F8W6Q6
    Related
    ENSP00000405647.2, ENST00000447302.6
    Conserved Domains (1) summary
    pfam04505
    Location:92 → 120
    CD225; Interferon-induced transmembrane protein

  5. NM_001098824.2 → NP_001092294.1  transmembrane protein 91 isoform e

    See identical proteins and their annotated locations for NP_001092294.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform e) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    BM675470, BM931402, DA673235
    Consensus CDS
    CCDS46084.1
    UniProtKB/TrEMBL
    F8W6Q6
    Related
    ENSP00000407003.2, ENST00000436170.6
    Conserved Domains (1) summary
    pfam04505
    Location:92 → 120
    CD225; Interferon-induced transmembrane protein

  6. NM_001098825.2 → NP_001092295.1  transmembrane protein 91 isoform c

    See identical proteins and their annotated locations for NP_001092295.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform c) is shorter and has a distinct C-terminus compared to isoform a. Variants 3, 6, and 8 all encode the same isoform (c).
    Source sequence(s)
    AC011462, AI214374, BM726200, R01772
    Consensus CDS
    CCDS46082.1
    UniProtKB/TrEMBL
    F8W6Q6
    Related
    ENSP00000413192.2, ENST00000413014.6
    Conserved Domains (1) summary
    pfam04505
    Location:92 → 124
    CD225; Interferon-induced transmembrane protein

  7. NM_001369862.1 → NP_001356791.1  transmembrane protein 91 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variant 2, encodes isoform b.
    Source sequence(s)
    AC011462
    Consensus CDS
    CCDS42572.1
    UniProtKB/TrEMBL
    F8W6Q6
    Conserved Domains (1) summary
    pfam04505
    Location:92 → 120
    CD225; Interferon-induced transmembrane protein

  8. NM_001369864.1 → NP_001356793.1  transmembrane protein 91 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 3 and 6, encodes isoform c.
    Source sequence(s)
    AC011462
    Consensus CDS
    CCDS46082.1
    UniProtKB/TrEMBL
    F8W6Q6
    Conserved Domains (1) summary
    pfam04505
    Location:92 → 124
    CD225; Interferon-induced transmembrane protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    41363947..41384083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    44184527..44205320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZNR0.1 GenPept UniProtKB/Swiss-Prot:Q6ZNR0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous