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DIO3OS DIO3 opposite strand upstream RNA [ Homo sapiens (human) ]

Gene ID: 64150, updated on 5-Mar-2024

Summary

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Official Symbol
DIO3OSprovided by HGNC
Official Full Name
DIO3 opposite strand upstream RNAprovided by HGNC
Primary source
HGNC:HGNC:20348
See related
Ensembl:ENSG00000258498 MIM:608523; AllianceGenome:HGNC:20348
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIO3-OS; DIO3-AS1; C14orf134; NCRNA00041
Summary
The mouse and human DIO3OS and DIO3 (MIM 601038) genes overlap and are transcribed in opposite directions. The mouse Dio3 gene is imprinted from the paternal allele during fetal development, suggesting that DIO3OS is a noncoding gene that may have a role in maintaining monoallelic expression of DIO3 (Hernandez et al., 2004 [PubMed 14962667]).[supplied by OMIM, Mar 2008]
Orthologs
mouse all
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Genomic context

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See DIO3OS in Genome Data Viewer
Location:
14q32.31
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (101552221..101560422, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (95787465..95795676, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (102018558..102026759, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370673 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:101988607-101989138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:101989139-101989669 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:101991618-101992451 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:101994118-101994949 Neighboring gene uncharacterized LOC105370674 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:102018566-102019765 Neighboring gene microRNA 1247 Neighboring gene iodothyronine deiodinase 3 Neighboring gene uncharacterized LOC105370675

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. KIF9‑AS1, LINC01272 and DIO3OS lncRNAs as novel biomarkers for inflammatory bowel disease. Wang S, et al. Mol Med Rep, 2018 Feb. PMID 29207070, Free PMC Article
  2. Complex organization and structure of sense and antisense transcripts expressed from the DIO3 gene imprinted locus. Hernandez A, et al. Genomics, 2004 Mar. PMID 14962667
  3. Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study. Velez Edwards DR, et al. Hum Genet, 2013 Mar. PMID 23192594, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Conserved LncRNA DIO3OS Restricts Hepatocellular Carcinoma Stemness by Interfering with NONO-Mediated Nuclear Export of ZEB1 mRNA.
    Title: The Conserved LncRNA DIO3OS Restricts Hepatocellular Carcinoma Stemness by Interfering with NONO-Mediated Nuclear Export of ZEB1 mRNA.
  2. there were significantly positive correlations in KIF9AS1, LINC01272 and DIO3OS expression between IBD tissue and plasma samples. Therefore, the present study indicated that KIF9AS1, LINC01272 and DIO3OS may be potential diagnostic biomarkers for IBD.
    Title: KIF9‑AS1, LINC01272 and DIO3OS lncRNAs as novel biomarkers for inflammatory bowel disease.
  3. We analyzed the human DIO3 genomic region and identified a gene (DIO3OS) that is transcribed in the antisense orientation.
    Title: Complex organization and structure of sense and antisense transcripts expressed from the DIO3 gene imprinted locus.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Other Names

  • DIO3 opposite strand (non-protein coding)
  • DIO3 opposite strand/antisense RNA (head to head)
  • DIO3 opposite strand/antisense RNA (non-protein coding)
  • deiodinase, iodothyronine, type III opposite strand
  • uterine-derived 14 kDa protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_152588.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AF469208, AI983003, BC111049
    Related
    ENST00000557109.6

  2. NR_152589.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AF305836, AF469200, BC111049
    Related
    ENST00000557532.6

  3. NR_152590.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AF305836, AL049836, BC111049
    Related
    ENST00000555174.6

  4. NR_152591.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AF305836, AF469199, BC065701, BC111049
    Related
    ENST00000554694.3

  5. NR_152592.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AF305836, BC065701, BC111049
    Related
    ENST00000557661.2

  6. NR_152593.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AF305836, AL049836, BC065701, BC111049, BI760536
    Related
    ENST00000554441.7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    101552221..101560422 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    95787465..95795676 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_022345.2: Suppressed sequence

    Description
    NM_022345.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.

  2. NR_002770.1: Suppressed sequence

    Description
    NR_002770.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version

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