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Ralb v-ral simian leukemia viral oncogene B [ Mus musculus (house mouse) ]

Gene ID: 64143, updated on 5-Mar-2024

Summary

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Official Symbol
Ralbprovided by MGI
Official Full Name
v-ral simian leukemia viral oncogene Bprovided by MGI
Primary source
MGI:MGI:1927244
See related
Ensembl:ENSMUSG00000004451 AllianceGenome:MGI:1927244
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730472O18Rik
Summary
Predicted to enable GTPase activity; enzyme binding activity; and guanyl ribonucleotide binding activity. Predicted to be involved in several processes, including cellular response to exogenous dsRNA; positive regulation of autophagosome assembly; and regulation of exocyst localization. Predicted to act upstream of or within apoptotic process and cell division. Predicted to be located in midbody. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; eye; heart; nervous system; and skin. Human ortholog(s) of this gene implicated in pancreatic adenocarcinoma. Orthologous to human RALB (RAS like proto-oncogene B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 48.8), large intestine adult (RPKM 23.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ralb in Genome Data Viewer
Location:
1 E2.3; 1 52.29 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (119398035..119432512, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (119470305..119504782, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33490 Neighboring gene predicted gene, 33575 Neighboring gene predicted gene, 46145 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:121388591-121388840 Neighboring gene STARR-positive B cell enhancer ABC_E1558 Neighboring gene predicted gene 29454 Neighboring gene RIKEN cDNA 3830432H09 gene Neighboring gene transmembrane protein 185B Neighboring gene predicted gene, 25322

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ral GTPases in Schwann cells promote radial axonal sorting in the peripheral nervous system. Ommer A, et al. J Cell Biol, 2019 Jul 1. PMID 31201267, Free PMC Article
  2. RalGTPases contribute to Schwann cell repair after nerve injury via regulation of process formation. Galino J, et al. J Cell Biol, 2019 Jul 1. PMID 31201266, Free PMC Article
  3. Ral isoforms are implicated in Fc gamma R-mediated phagocytosis: activation of phospholipase D by RalA. Corrotte M, et al. J Immunol, 2010 Sep 1. PMID 20679536
  4. Tissue-specific expression of GTPas RalA and RalB during embryogenesis and regulation by epithelial-mesenchymal interaction. Zhao Z, et al. Mech Dev, 2000 Oct. PMID 11025226
  5. Mouse Platelet Ral GTPases Control P-Selectin Surface Expression, Regulating Platelet-Leukocyte Interaction. Wersäll A, et al. Arterioscler Thromb Vasc Biol, 2018 Apr. PMID 29437579

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. While lack of only one Ral GTPase was dispensable for early peripheral nerve development, ablation of both RalA and RalB resulted in persistent radial sorting defects, associated with hallmarks of deficits in Schwann cell process formation and maintenance.
    Title: Ral GTPases in Schwann cells promote radial axonal sorting in the peripheral nervous system.
  2. Ablation of both RalA and RalB (but not individually) in Schwann cell resulted in impaired axon remyelination and target reinnervation following nerve injury, which resulted in slowed recovery of motor function.
    Title: RalGTPases contribute to Schwann cell repair after nerve injury via regulation of process formation.
  3. Platelet Ral GTPases primarily control P-selectin surface expression, in turn regulating platelet-leukocyte interaction.
    Title: Mouse Platelet Ral GTPases Control P-Selectin Surface Expression, Regulating Platelet-Leukocyte Interaction.
  4. This study identifies a novel regulatory crosstalk between Ral and Arf6 that controls Ral function in cells.
    Title: Ral-Arf6 crosstalk regulates Ral dependent exocyst trafficking and anchorage independent growth signalling.
  5. striking isoform-specific consequences of distinct CAAX-signaled posttranslational modifications that contribute to the divergent subcellular localization and activity of RalA and RalB.
    Title: Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases.
  6. findings show either RALA or RALB is sufficient for tumor growth; either RALA or RALB is sufficient for cell proliferation; RALA and RALB act in a redundant fashion
    Title: Genetic deletion of RALA and RALB small GTPases reveals redundant functions in development and tumorigenesis.
  7. Endogenous RalB plays a negative role in the ingestion process of Fc gamma receptor-mediated macrophage phagocytosis.
    Title: Ral isoforms are implicated in Fc gamma R-mediated phagocytosis: activation of phospholipase D by RalA.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
  
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to exogenous dsRNA ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of exocyst assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of exocyst localization ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ras-related protein Ral-B
Names
v-ral simian leukemia viral oncogene homolog B (ras related)
NP_071722.1
XP_006529845.1
XP_036008626.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022327.5 → NP_071722.1  ras-related protein Ral-B

    See identical proteins and their annotated locations for NP_071722.1

    Status: VALIDATED

    Source sequence(s)
    AK033193, AK159993, BE943587, BY237628
    Consensus CDS
    CCDS15225.1
    UniProtKB/Swiss-Prot
    Q3TVS5, Q9JIW9
    UniProtKB/TrEMBL
    Q8CCG5
    Related
    ENSMUSP00000004565.9, ENSMUST00000004565.15
    Conserved Domains (1) summary
    cd04139
    Location:15 → 178
    RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    119398035..119432512 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529782.3 → XP_006529845.1  ras-related protein Ral-B isoform X1

    See identical proteins and their annotated locations for XP_006529845.1

    UniProtKB/Swiss-Prot
    Q3TVS5, Q9JIW9
    UniProtKB/TrEMBL
    Q8CCG5
    Conserved Domains (1) summary
    cd04139
    Location:15 → 178
    RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB

  2. XM_036152733.1 → XP_036008626.1  ras-related protein Ral-B isoform X1

    UniProtKB/Swiss-Prot
    Q3TVS5, Q9JIW9
    UniProtKB/TrEMBL
    Q8CCG5
    Conserved Domains (1) summary
    cd04139
    Location:15 → 178
    RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JIW9.1 GenPept UniProtKB/Swiss-Prot:Q9JIW9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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