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LINC02912 long intergenic non-protein coding RNA 2912 [ Homo sapiens (human) ]

Gene ID: 641384, updated on 10-Oct-2023

Summary

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Official Symbol
LINC02912provided by HGNC
Official Full Name
long intergenic non-protein coding RNA 2912provided by HGNC
Primary source
HGNC:HGNC:32295
See related
Ensembl:ENSG00000280055 AllianceGenome:HGNC:32295
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMEM75
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
8q24.21
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (127946559..127948723, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (129074414..129076578, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (128958805..128960969, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr8:128744882-128745383 Neighboring gene origin of replication upstream of MYC Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19530 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:128754894-128756093 Neighboring gene MYC proto-oncogene, bHLH transcription factor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128805180-128805750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19531 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19533 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128806893-128807462 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128807463-128808034 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19534 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128814781-128815422 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128815423-128816064 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:128816065-128816704 Neighboring gene Sharpr-MPRA regulatory region 14038 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128821670-128822570 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128822571-128823470 Neighboring gene Sharpr-MPRA regulatory region 15510 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128830247-128830786 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128832947-128833486 Neighboring gene microRNA 1204 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:128834567-128835106 Neighboring gene Pvt1 oncogene Neighboring gene ReSE screen-validated silencer GRCh37_chr8:128858753-128858938 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128862019-128862636 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128864303-128865152 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:128866418-128867617 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128879341-128879948 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128888845-128889392 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:128891961-128892128 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128893083-128893582 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27949 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27950 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27951 Neighboring gene Sharpr-MPRA regulatory region 1737 Neighboring gene CRISPRi-validated MYC e1 enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128913423-128914077 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128916503-128917004 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128920055-128920986 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128920987-128921919 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:128923753-128924342 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27953 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128932048-128932575 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128936915-128937414 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128951647-128952169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128969595-128970406 Neighboring gene CRISPRi-validated MYC e2 enhancer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128976545-128977156 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19535 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27954 Neighboring gene microRNA 1205 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:129004541-129005042 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:129005043-129005542 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27956 Neighboring gene RNA, variant U1 small nuclear 32

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Long noncoding RNA TMEM75 promotes colorectal cancer progression by activation of SIM2. Jin X, et al. Gene, 2018 Oct 30. PMID 29964097
  2. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, et al. Nat Genet, 2014 Mar. PMID 24509480, Free PMC Article
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. Comuzzie AG, et al. PLoS One, 2012. PMID 23251661, Free PMC Article
  4. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TMEM75 functions as an oncogene relying on activation of SIM2 in colorectal cancer.
    Title: Long noncoding RNA TMEM75 promotes colorectal cancer progression by activation of SIM2.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Other Names

  • transmembrane protein 75

Clone Names

  • FLJ36105

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_103558.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC103705, AK093424
    Related
    ENST00000624314.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    127946559..127948723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    129074414..129076578 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001037234.1: Suppressed sequence

    Description
    NM_001037234.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N9X5.1 GenPept UniProtKB/Swiss-Prot:Q8N9X5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Miscellaneous