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Tomm40l translocase of outer mitochondrial membrane 40-like [ Mus musculus (house mouse) ]

Gene ID: 641376, updated on 11-Apr-2024

Summary

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Official Symbol
Tomm40lprovided by MGI
Official Full Name
translocase of outer mitochondrial membrane 40-likeprovided by MGI
Primary source
MGI:MGI:3589112
See related
Ensembl:ENSMUSG00000005674 AllianceGenome:MGI:3589112
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable mitochondrion targeting sequence binding activity; preprotein binding activity; and protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to act upstream of or within ion transport and protein transport. Located in mitochondrion. Orthologous to human TOMM40L (translocase of outer mitochondrial membrane 40 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 18.3), heart adult (RPKM 15.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tomm40l in Genome Data Viewer
Location:
1 H3; 1 79.22 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171043579..171050020, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171217802..171222514, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2018 Neighboring gene myelin protein zero Neighboring gene Purkinje cell protein 4-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E1573 Neighboring gene nuclear receptor subfamily 1, group I, member 3 Neighboring gene apolipoprotein A-II Neighboring gene Fc receptor, IgE, high affinity I, gamma polypeptide Neighboring gene NADH:ubiquinone oxidoreductase core subunit S2 Neighboring gene STARR-seq mESC enhancer starr_03024 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Chung YC, et al. Gene Expr Patterns, 2011 Jan-Feb. PMID 20932939
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mitochondrion targeting sequence binding ISO
Inferred from Sequence Orthology
more info
  
enables porin activity IEA
Inferred from Electronic Annotation
more info
  
enables preprotein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
part_of mitochondrial outer membrane translocase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial outer membrane translocase complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
part_of pore complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial import receptor subunit TOM40B
Names
translocase of outer mitochondrial membrane 40 homolog-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037170.3 → NP_001032247.1  mitochondrial import receptor subunit TOM40B

    See identical proteins and their annotated locations for NP_001032247.1

    Status: VALIDATED

    Source sequence(s)
    AC084821, AC163497
    Consensus CDS
    CCDS15481.1
    UniProtKB/Swiss-Prot
    Q9CZR3
    UniProtKB/TrEMBL
    D3YXS8
    Related
    ENSMUSP00000005817.3, ENSMUST00000005817.9
    Conserved Domains (1) summary
    cd07305
    Location:24 → 308
    Porin3_Tom40; Translocase of outer mitochondrial membrane 40 (Tom40)

  2. NM_001412746.1 → NP_001399675.1  mitochondrial import receptor subunit TOM40B

    Status: VALIDATED

    Source sequence(s)
    AC084821, AC163497
    UniProtKB/Swiss-Prot
    Q9CZR3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    171043579..171050020 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZR3.1 GenPept UniProtKB/Swiss-Prot:Q9CZR3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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