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Pinlyp phospholipase A2 inhibitor and LY6/PLAUR domain containing [ Mus musculus (house mouse) ]

Gene ID: 641361, updated on 5-Mar-2024

Summary

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Official Symbol
Pinlypprovided by MGI
Official Full Name
phospholipase A2 inhibitor and LY6/PLAUR domain containingprovided by MGI
Primary source
MGI:MGI:3615324
See related
Ensembl:ENSMUSG00000011632 AllianceGenome:MGI:3615324
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310033E01Rik
Summary
Predicted to enable phospholipase inhibitor activity. Predicted to be located in extracellular region. Orthologous to human PINLYP (phospholipase A2 inhibitor and LY6/PLAUR domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 15.5), testis adult (RPKM 6.0) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A3; 7 11.38 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24241079..24246045, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (24541654..24546668, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 428 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25315449-25315632 Neighboring gene immunity-related GTPase family, Q Neighboring gene STARR-seq mESC enhancer starr_18269 Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 1 Neighboring gene zinc finger protein 575 Neighboring gene ethylmalonic encephalopathy 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phospholipase A2 inhibitor and LY6/PLAUR domain-containing protein PINLYP regulates type I interferon innate immunity. Liu Z, et al. Proc Natl Acad Sci U S A, 2022 Jan 4. PMID 34969857, Free PMC Article
  2. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Miyata H, et al. Proc Natl Acad Sci U S A, 2016 Jul 12. PMID 27357688, Free PMC Article
  3. Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. Loughner CL, et al. Hum Genomics, 2016 Apr 21. PMID 27098205, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phospholipase A2 inhibitor and LY6/PLAUR domain-containing protein PINLYP regulates type I interferon innate immunity.
    Title: Phospholipase A2 inhibitor and LY6/PLAUR domain-containing protein PINLYP regulates type I interferon innate immunity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables phospholipase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037143.3 → NP_001032220.1  phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein precursor

    See identical proteins and their annotated locations for NP_001032220.1

    Status: VALIDATED

    Source sequence(s)
    AC161166
    Consensus CDS
    CCDS20954.1
    UniProtKB/Swiss-Prot
    Q9CQD7, Q9D6V5
    UniProtKB/TrEMBL
    B2RSX2
    Related
    ENSMUSP00000011776.7, ENSMUST00000011776.8
    Conserved Domains (1) summary
    cl10471
    Location:27 → 107
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    24241079..24246045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540274.5 → XP_006540337.1  phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein isoform X1

    See identical proteins and their annotated locations for XP_006540337.1

    UniProtKB/Swiss-Prot
    Q9CQD7, Q9D6V5
    UniProtKB/TrEMBL
    B2RSX2
    Conserved Domains (1) summary
    cl10471
    Location:27 → 107
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQD7.1 GenPept UniProtKB/Swiss-Prot:Q9CQD7

Gene LinkOut

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