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CENPK centromere protein K [ Homo sapiens (human) ]

Gene ID: 64105, updated on 5-Mar-2024

Summary

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Official Symbol
CENPKprovided by HGNC
Official Full Name
centromere protein Kprovided by HGNC
Primary source
HGNC:HGNC:29479
See related
Ensembl:ENSG00000123219 MIM:611502; AllianceGenome:HGNC:29479
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P33; Solt; CENP-K; FKSG14; AF5alpha
Summary
CENPK is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in testis (RPKM 1.8), bone marrow (RPKM 1.7) and 19 other tissues See more
Orthologs
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Genomic context

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Location:
5q12.3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (65495624..65563168, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (66338058..66384928, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (64812119..64858995, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 6 Neighboring gene ribosomal protein S2 pseudogene 23 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:64777627-64778126 Neighboring gene uncharacterized LOC124900986 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:64780998-64781506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:64781507-64782013 Neighboring gene MPRA-validated peak5269 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:64855281-64855780 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:64858250-64858911 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:64858912-64859572 Neighboring gene peptidylprolyl isomerase domain and WD repeat containing 1 Neighboring gene RNA, U6 small nuclear 540, pseudogene Neighboring gene tripartite motif containing 23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Overexpression of centromere protein K (CENPK) gene in Differentiated Thyroid Carcinoma promote cell Proliferation and Migration. Li Q, et al. Bioengineered, 2021 Dec. PMID 33904381, Free PMC Article
  2. Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of Cullin 4A. Li X, et al. World J Gastroenterol, 2022 Oct 7. PMID 36312839, Free PMC Article
  3. Centromeric protein K (CENPK) promotes gastric cancer proliferation and migration via interacting with XRCC5. Tian H, et al. Gastric Cancer, 2022 Sep. PMID 35715658
  4. N(6)-methyladenosine modification of CENPK mRNA by ZC3H13 promotes cervical cancer stemness and chemoresistance. Lin X, et al. Mil Med Res, 2022 Apr 14. PMID 35418160, Free PMC Article
  5. Fusion of the MLL gene with two different genes, AF-6 and AF-5alpha, by a complex translocation involving chromosomes 5, 6, 8 and 11 in infant leukemia. Taki T, et al. Oncogene, 1996 Nov 21. PMID 8950979

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of Cullin 4A.
    Title: Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of Cullin 4A.
  2. Centromeric protein K (CENPK) promotes gastric cancer proliferation and migration via interacting with XRCC5.
    Title: Centromeric protein K (CENPK) promotes gastric cancer proliferation and migration via interacting with XRCC5.
  3. N(6)-methyladenosine modification of CENPK mRNA by ZC3H13 promotes cervical cancer stemness and chemoresistance.
    Title: N(6)-methyladenosine modification of CENPK mRNA by ZC3H13 promotes cervical cancer stemness and chemoresistance.
  4. Overexpression of centromere protein K (CENPK) gene in Differentiated Thyroid Carcinoma promote cell Proliferation and Migration.
    Title: Overexpression of centromere protein K (CENPK) gene in Differentiated Thyroid Carcinoma promote cell Proliferation and Migration.
  5. the vertebrate KNL1 counterpart is essential for chromosome segregation and is required to localize a subset of outer kinetochore proteins.
    Title: KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of centromere protein K (CENPK) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromosome segregation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in kinetochore assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of inner kinetochore IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
centromere protein K
Names
SoxLZ/Sox6-binding protein Solt
interphase centromere complex protein 37
leucine zipper protein FKSG14
protein AF-5alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267038.2 → NP_001253967.1  centromere protein K isoform 1

    See identical proteins and their annotated locations for NP_001253967.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC005400, BC008504, BG502832
    Consensus CDS
    CCDS3984.1
    UniProtKB/Swiss-Prot
    Q9BS16, Q9H4L0
    Related
    ENSP00000422421.1, ENST00000514814.5
    Conserved Domains (1) summary
    pfam11802
    Location:10 → 269
    CENP-K; Centromere-associated protein K

  2. NM_001349367.2 → NP_001336296.1  centromere protein K isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in its 5' coding region, resulting in use of an alternate start codon, compared to variant 1. The encoded isoform (3) has a slightly longer, but distinct N-terminus compared to isoform 1.
    Source sequence(s)
    BC005400, BC008504, BG502832, BG527280
    Conserved Domains (1) summary
    pfam11802
    Location:12 → 271
    CENP-K; Centromere-associated protein K

  3. NM_001349368.2 → NP_001336297.1  centromere protein K isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and lacks an alternate in-frame exon in its central coding region, compared to variant 1. The encoded isoform (4) has a shorter N-terminus and lacks an internal segment compared to isoform 1.
    Source sequence(s)
    BC005400, BC008504, BF211376, BG502832, BG505115
    Consensus CDS
    CCDS87299.1
    UniProtKB/TrEMBL
    D6RJF0
    Related
    ENSP00000425686.1, ENST00000510693.5
    Conserved Domains (1) summary
    pfam11802
    Location:1 → 206
    CENP-K; Centromere-associated protein K

  4. NM_001349369.2 → NP_001336298.1  centromere protein K isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and contains an alternate terminal exon, resulting in a novel 3' coding region, compared to variant 1. The encoded isoform (5) has a shorter N-terminus and a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC016620, BC005400, BG502832, BG505115
    Conserved Domains (1) summary
    pfam11802
    Location:1 → 189
    CENP-K; Centromere-associated protein K

  5. NM_022145.5 → NP_071428.2  centromere protein K isoform 1

    See identical proteins and their annotated locations for NP_071428.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC008504
    Consensus CDS
    CCDS3984.1
    UniProtKB/Swiss-Prot
    Q9BS16, Q9H4L0
    Related
    ENSP00000379911.1, ENST00000396679.6
    Conserved Domains (1) summary
    pfam11802
    Location:10 → 269
    CENP-K; Centromere-associated protein K

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    65495624..65563168 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009696.3 → XP_016865185.1  centromere protein K isoform X7

  2. XM_047417488.1 → XP_047273444.1  centromere protein K isoform X12

  3. XM_047417485.1 → XP_047273441.1  centromere protein K isoform X8

  4. XM_047417487.1 → XP_047273443.1  centromere protein K isoform X11

  5. XM_017009695.2 → XP_016865184.1  centromere protein K isoform X5

  6. XM_011543538.3 → XP_011541840.1  centromere protein K isoform X4

    Conserved Domains (1) summary
    pfam11802
    Location:12 → 238
    CENP-K; Centromere-associated protein K

  7. XM_024446148.2 → XP_024301916.1  centromere protein K isoform X14

    Conserved Domains (1) summary
    pfam11802
    Location:18 → 172
    CENP-K; Centromere-associated protein K

  8. XM_011543541.3 → XP_011541843.1  centromere protein K isoform X10

    See identical proteins and their annotated locations for XP_011541843.1

    Conserved Domains (1) summary
    pfam11802
    Location:18 → 205
    CENP-K; Centromere-associated protein K

  9. XM_047417480.1 → XP_047273436.1  centromere protein K isoform X1

  10. XM_024446145.2 → XP_024301913.1  centromere protein K isoform X10

    Conserved Domains (1) summary
    pfam11802
    Location:18 → 205
    CENP-K; Centromere-associated protein K

  11. XM_047417486.1 → XP_047273442.1  centromere protein K isoform X9

  12. XM_047417481.1 → XP_047273437.1  centromere protein K isoform X1

  13. XM_011543542.3 → XP_011541844.1  centromere protein K isoform X10

    See identical proteins and their annotated locations for XP_011541844.1

    Conserved Domains (1) summary
    pfam11802
    Location:18 → 205
    CENP-K; Centromere-associated protein K

  14. XM_011543535.3 → XP_011541837.1  centromere protein K isoform X1

    See identical proteins and their annotated locations for XP_011541837.1

    Conserved Domains (1) summary
    pfam11802
    Location:12 → 271
    CENP-K; Centromere-associated protein K

  15. XM_047417484.1 → XP_047273440.1  centromere protein K isoform X6

  16. XM_017009692.2 → XP_016865181.1  centromere protein K isoform X2

    UniProtKB/Swiss-Prot
    Q9BS16, Q9H4L0
    Conserved Domains (1) summary
    pfam11802
    Location:10 → 269
    CENP-K; Centromere-associated protein K

  17. XM_047417483.1 → XP_047273439.1  centromere protein K isoform X3

    UniProtKB/TrEMBL
    D6RHD3

  18. XM_017009690.2 → XP_016865179.1  centromere protein K isoform X2

    UniProtKB/Swiss-Prot
    Q9BS16, Q9H4L0
    Conserved Domains (1) summary
    pfam11802
    Location:10 → 269
    CENP-K; Centromere-associated protein K

  19. XM_017009694.2 → XP_016865183.1  centromere protein K isoform X3

    UniProtKB/TrEMBL
    D6RHD3
    Conserved Domains (1) summary
    pfam11802
    Location:1 → 239
    CENP-K; Centromere-associated protein K

  20. XM_011543536.3 → XP_011541838.1  centromere protein K isoform X2

    See identical proteins and their annotated locations for XP_011541838.1

    UniProtKB/Swiss-Prot
    Q9BS16, Q9H4L0
    Conserved Domains (1) summary
    pfam11802
    Location:10 → 269
    CENP-K; Centromere-associated protein K

  21. XM_047417489.1 → XP_047273445.1  centromere protein K isoform X13

RNA

  1. XR_007058619.1 RNA Sequence

  2. XR_007058618.1 RNA Sequence

  3. XR_007058617.1 RNA Sequence

  4. XR_001742177.2 RNA Sequence

  5. XR_007058615.1 RNA Sequence

  6. XR_007058616.1 RNA Sequence

  7. XR_948282.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    66338058..66384928 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353074.1 → XP_054209049.1  centromere protein K isoform X12

  2. XM_054353068.1 → XP_054209043.1  centromere protein K isoform X15

  3. XM_054353069.1 → XP_054209044.1  centromere protein K isoform X8

  4. XM_054353073.1 → XP_054209048.1  centromere protein K isoform X11

  5. XM_054353066.1 → XP_054209041.1  centromere protein K isoform X5

  6. XM_054353065.1 → XP_054209040.1  centromere protein K isoform X4

  7. XM_054353076.1 → XP_054209051.1  centromere protein K isoform X14

  8. XM_054353070.1 → XP_054209045.1  centromere protein K isoform X10

  9. XM_054353071.1 → XP_054209046.1  centromere protein K isoform X10

  10. XM_054353072.1 → XP_054209047.1  centromere protein K isoform X10

  11. XM_054353067.1 → XP_054209042.1  centromere protein K isoform X6

  12. XM_054353061.1 → XP_054209036.1  centromere protein K isoform X1

  13. XM_054353063.1 → XP_054209038.1  centromere protein K isoform X2

    UniProtKB/Swiss-Prot
    Q9BS16, Q9H4L0

  14. XM_054353062.1 → XP_054209037.1  centromere protein K isoform X2

    UniProtKB/Swiss-Prot
    Q9BS16, Q9H4L0

  15. XM_054353064.1 → XP_054209039.1  centromere protein K isoform X3

    UniProtKB/TrEMBL
    D6RHD3

  16. XM_054353075.1 → XP_054209050.1  centromere protein K isoform X13

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BS16.1 GenPept UniProtKB/Swiss-Prot:Q9BS16

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