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Smoc1 SPARC related modular calcium binding 1 [ Mus musculus (house mouse) ]

Gene ID: 64075, updated on 5-Mar-2024

Summary

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Official Symbol
Smoc1provided by MGI
Official Full Name
SPARC related modular calcium binding 1provided by MGI
Primary source
MGI:MGI:1929878
See related
Ensembl:ENSMUSG00000021136 AllianceGenome:MGI:1929878
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SRG; 2600002F22Rik
Summary
Enables extracellular matrix binding activity. Involved in eye development and limb development. Acts upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Located in basement membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hindlimb; and sensory organ. Used to study microphthalmia with limb anomalies. Human ortholog(s) of this gene implicated in microphthalmia with limb anomalies. Orthologous to human SMOC1 (SPARC related modular calcium binding 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 114.5), subcutaneous fat pad adult (RPKM 35.9) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 D1; 12 37.28 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (81073582..81233188)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (81026808..81186414)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5338 Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 1 Neighboring gene STARR-positive B cell enhancer mm9_chr12:82083313-82083614 Neighboring gene serine and arginine-rich splicing factor 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:82164637-82164838 Neighboring gene ribosomal protein S8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_32668 Neighboring gene microRNA 3067 Neighboring gene solute carrier family 8 (sodium/calcium exchanger), member 3 Neighboring gene predicted gene 3693 Neighboring gene STARR-seq mESC enhancer starr_32669 Neighboring gene STARR-seq mESC enhancer starr_32670 Neighboring gene predicted gene, 53730

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The heparin-binding activity of secreted modular calcium-binding protein 1 (SMOC-1) modulates its cell adhesion properties. Klemenčič M, et al. PLoS One, 2013. PMID 23437253, Free PMC Article
  2. Eye development genes and known syndromes. Slavotinek AM. Mol Genet Metab, 2011 Dec. PMID 22005280, Free PMC Article
  3. Secreted modular calcium-binding protein-1 localization during mouse embryogenesis. Gersdorff N, et al. Histochem Cell Biol, 2006 Dec. PMID 16736127
  4. Deficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss. Morkmued S, et al. Sci Rep, 2020 Sep 9. PMID 32908163, Free PMC Article
  5. Fasting before or after wound injury accelerates wound healing through the activation of pro-angiogenic SMOC1 and SCG2. Luo MJ, et al. Theranostics, 2020. PMID 32206122, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Smoc1 and Smoc2 regulate bone formation as downstream molecules of Runx2.
    Title: Smoc1 and Smoc2 regulate bone formation as downstream molecules of Runx2.
  2. Fasting before or after wound injury accelerates wound healing through the activation of pro-angiogenic SMOC1 and SCG2.
    Title: Fasting before or after wound injury accelerates wound healing through the activation of pro-angiogenic SMOC1 and SCG2.
  3. SMOC1 is an activin-like kinase antagonist produced by endothelial cells that tips TGF-beta signalling towards ALK1 activation
    Title: Role of secreted modular calcium-binding protein 1 (SMOC1) in transforming growth factor β signalling and angiogenesis.
  4. The heparin-binding activity of secreted modular calcium-binding protein 1 (SMOC-1) modulates its cell adhesion properties.
    Title: The heparin-binding activity of secreted modular calcium-binding protein 1 (SMOC-1) modulates its cell adhesion properties.
  5. these findings indicate that SMOC1/Smoc1 is essential for ocular and limb development in both humans and mice.
    Title: SMOC1 is essential for ocular and limb development in humans and mice.
  6. SMOC1 and SMOC2 may mediate intercellular signaling and cell type-specific differentiation during gonad and reproductive tract development
    Title: Developmental expression of Smoc1 and Smoc2 suggests potential roles in fetal gonad and reproductive tract differentiation.
  7. expression of SMOC-1 examined in the early embryo day 7, as well as in following embryonic stages on days 12, 14, 16 & 18; broad and organ-specific distribution suggests multifunctional roles of SMOC-1 during mouse embryogenesis
    Title: Secreted modular calcium-binding protein-1 localization during mouse embryogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables extracellular matrix binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables extracellular matrix binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within extracellular matrix organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in eye development ISO
Inferred from Sequence Orthology
more info
  
involved_in limb development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in limb development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of cell-substrate adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in basement membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basement membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SPARC-related modular calcium-binding protein 1
Names
SMOC-1
SPARC-related gene protein
SPARC-related protein
secreted modular calcium binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146217.1 → NP_001139689.1  SPARC-related modular calcium-binding protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001139689.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC124384, AK040931
    Consensus CDS
    CCDS49102.1
    UniProtKB/TrEMBL
    A0A0R4J1E4, D3Z3A3
    Related
    ENSMUSP00000105976.3, ENSMUST00000110347.9
    Conserved Domains (5) summary
    smart00280
    Location:42 → 86
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:236 → 302
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:374 → 435
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
    pfam00086
    Location:94 → 157
    Thyroglobulin_1; Thyroglobulin type-1 repeat
    pfam16597
    Location:158 → 227
    Thyroglob_assoc; Thyroglobulin_1 repeat associated disordered domain

  2. NM_022316.2 → NP_071711.2  SPARC-related modular calcium-binding protein 1 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AC124384, AK040931
    Consensus CDS
    CCDS26017.1
    UniProtKB/TrEMBL
    D3Z3A3, E9QKW2
    Related
    ENSMUSP00000021564.5, ENSMUST00000021564.11
    Conserved Domains (5) summary
    smart00280
    Location:42 → 86
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:225 → 291
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:363 → 424
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
    pfam00086
    Location:94 → 157
    Thyroglobulin_1; Thyroglobulin type-1 repeat
    pfam16597
    Location:158 → 216
    Thyroglob_assoc; Thyroglobulin_1 repeat associated disordered domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    81073582..81233188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516135.5 → XP_006516198.1  SPARC-related modular calcium-binding protein 1 isoform X1

    UniProtKB/TrEMBL
    D3Z3A3
    Conserved Domains (4) summary
    cd16240
    Location:318 → 432
    EFh_SPARC_SMOC1; EF-hand, extracellular calcium-binding (EC) motif, found in secreted modular calcium-binding protein 1 (SMOC-1)
    pfam00086
    Location:87 → 150
    Thyroglobulin_1; Thyroglobulin type-1 repeat
    pfam07648
    Location:35 → 79
    Kazal_2; Kazal-type serine protease inhibitor domain
    pfam16597
    Location:151 → 222
    Thyroglob_assoc; Thyroglobulin_1 repeat associated disordered domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BLY1.2 GenPept UniProtKB/Swiss-Prot:Q8BLY1

Gene LinkOut

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