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Smoc2 SPARC related modular calcium binding 2 [ Mus musculus (house mouse) ]

Gene ID: 64074, updated on 21-Apr-2024

Summary

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Official Symbol
Smoc2provided by MGI
Official Full Name
SPARC related modular calcium binding 2provided by MGI
Primary source
MGI:MGI:1929881
See related
Ensembl:ENSMUSG00000023886 AllianceGenome:MGI:1929881
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Smoc2l; 1700056C05Rik; 5430426J21Rik
Summary
Enables calcium ion binding activity and heparin binding activity. Acts upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Located in basement membrane and interstitial matrix. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; impulse conducting system; and skin. Orthologous to human SMOC2 (SPARC related modular calcium binding 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 125.2), subcutaneous fat pad adult (RPKM 55.4) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A2; 17 8.95 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (14499768..14625052)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (14279490..14404790)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41531 Neighboring gene predicted gene, 34772 Neighboring gene predicted gene, 34567 Neighboring gene predicted gene, 52280 Neighboring gene STARR-seq mESC enhancer starr_41893 Neighboring gene RIKEN cDNA 4930474M22 gene Neighboring gene predicted gene, 38551 Neighboring gene VISTA enhancer mm1999 Neighboring gene predicted gene, 34916 Neighboring gene STARR-seq mESC enhancer starr_41894 Neighboring gene predicted gene, 53989

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A SMOC2 variant inhibits BMP signaling by competitively binding to BMPR1B and causes growth plate defects. Long F, et al. Bone, 2021 Jan. PMID 33059102
  2. Canine Brachycephaly Is Associated with a Retrotransposon-Mediated Missplicing of SMOC2. Marchant TW, et al. Curr Biol, 2017 Jun 5. PMID 28552356, Free PMC Article
  3. The widely expressed extracellular matrix protein SMOC-2 promotes keratinocyte attachment and migration. Maier S, et al. Exp Cell Res, 2008 Aug 1. PMID 18582461
  4. microRNA-148a in Exosomes Derived from Bone Marrow Mesenchymal Stem Cells Alleviates Cardiomyocyte Apoptosis in Atrial Fibrillation by Inhibiting SMOC2. Zhang W, et al. Mol Biotechnol, 2022 Oct. PMID 35397056
  5. Deficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss. Morkmued S, et al. Sci Rep, 2020 Sep 9. PMID 32908163, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. microRNA-148a in Exosomes Derived from Bone Marrow Mesenchymal Stem Cells Alleviates Cardiomyocyte Apoptosis in Atrial Fibrillation by Inhibiting SMOC2.
    Title: microRNA-148a in Exosomes Derived from Bone Marrow Mesenchymal Stem Cells Alleviates Cardiomyocyte Apoptosis in Atrial Fibrillation by Inhibiting SMOC2.
  2. Smoc1 and Smoc2 regulate bone formation as downstream molecules of Runx2.
    Title: Smoc1 and Smoc2 regulate bone formation as downstream molecules of Runx2.
  3. A SMOC2 variant inhibits BMP signaling by competitively binding to BMPR1B and causes growth plate defects.
    Title: A SMOC2 variant inhibits BMP signaling by competitively binding to BMPR1B and causes growth plate defects.
  4. Liver fibrosis induced by high fat diet was clearly ameliorated by SMOC2 deficiency mainly through inhibiting transforming growth factor (TGF)-beta1 expression.
    Title: Secreted modular calcium-binding protein 2 promotes high fat diet (HFD)-induced hepatic steatosis through enhancing lipid deposition, fibrosis and inflammation via targeting TGF-β1.
  5. SMOC2 can act as an inhibitor of mineralization; there is a possible role for SMOC2 to prevent calcification disorders.
    Title: SMOC2 inhibits calcification of osteoprogenitor and endothelial cells.
  6. By using microRNA array, we identified a large number of microRNAs that showed different expression between wild-type Runx2 group and mutant groups. The aim of this study is to find out the effect of mmu-miR-1963, which was downregulated in all mutant Runx2 groups, on the ameloblast differentiation of LS8 cells
    Title: mmu-miR-1963 negatively regulates the ameloblast differentiation of LS8 cell line by directly targeting Smoc2 3'UTR.
  7. SMOC1 and SMOC2 may mediate intercellular signaling and cell type-specific differentiation during gonad and reproductive tract development
    Title: Developmental expression of Smoc1 and Smoc2 suggests potential roles in fetal gonad and reproductive tract differentiation.
  8. results indicate that Smoc2 is a novel transcriptional target of activated Ahr. Perturbation of Smoc2 expression may mediate the adverse developmental effects of environmental aryl-hydrocarbon exposure
    Title: The developmentally-regulated Smoc2 gene is repressed by Aryl-hydrocarbon receptor (Ahr) signaling.
  9. SMOC-2 contributes to cell cycle progression by maintaining ILK activity during G1.
    Title: The SPARC-related factor SMOC-2 promotes growth factor-induced cyclin D1 expression and DNA synthesis via integrin-linked kinase.
  10. SMOC-2, like other members of the BM40/SPARC family, acts as a regulator of cell-matrix interactions.
    Title: The widely expressed extracellular matrix protein SMOC-2 promotes keratinocyte attachment and migration.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables extracellular matrix binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosaminoglycan binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heparin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within extracellular matrix organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cell-substrate adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of endothelial cell chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vascular endothelial growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vascular wound healing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in basement membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basement membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
  
located_in collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in interstitial matrix IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
SPARC-related modular calcium-binding protein 2
Names
SMOC-2
secreted modular calcium-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022315.2 → NP_071710.2  SPARC-related modular calcium-binding protein 2 precursor

    See identical proteins and their annotated locations for NP_071710.2

    Status: VALIDATED

    Source sequence(s)
    AK030958, BB840063, BY690973
    Consensus CDS
    CCDS37442.1
    UniProtKB/Swiss-Prot
    Q8CD91, Q8VCM1, Q9D9K2, Q9ER95
    UniProtKB/TrEMBL
    Q3TVR8
    Related
    ENSMUSP00000024660.9, ENSMUST00000024660.9
    Conserved Domains (4) summary
    smart00280
    Location:39 → 84
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:215 → 281
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:352 → 413
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
    pfam16597
    Location:154 → 212
    Thyroglob_assoc; Thyroglobulin_1 repeat associated disordered domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    14499768..14625052
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524777.4 → XP_006524840.1  SPARC-related modular calcium-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A3B2WCK7, Q3TVR8
    Related
    ENSMUSP00000156572.2, ENSMUST00000233344.2
    Conserved Domains (5) summary
    smart00280
    Location:39 → 84
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:226 → 292
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd16241
    Location:315 → 428
    EFh_SPARC_SMOC2; EF-hand, extracellular calcium-binding (EC) motif, found in secreted modular calcium-binding protein 2 (SMOC-2)
    pfam00086
    Location:90 → 153
    Thyroglobulin_1; Thyroglobulin type-1 repeat
    pfam16597
    Location:154 → 225
    Thyroglob_assoc; Thyroglobulin_1 repeat associated disordered domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CD91.1 GenPept UniProtKB/Swiss-Prot:Q8CD91

Gene LinkOut

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