Yeats4 YEATS domain containing 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Yeats4provided by MGI
Official Full Name: YEATS domain containing 4provided by MGI
Primary source: MGI:MGI:1927224
See related: Ensembl:ENSMUSG00000020171 AllianceGenome:MGI:1927224
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GAS41; NuBI-1; 4930573H17Rik; B230215M10Rik
Summary: Predicted to enable lysine-acetylated histone binding activity and protein C-terminus binding activity. Predicted to be involved in histone H2A acetylation and histone H4 acetylation. Predicted to act upstream of or within chromatin organization and regulation of growth. Located in nucleoplasm. Is expressed in genitourinary system; sensory organ; tooth; and trunk somite. Orthologous to human YEATS4 (YEATS domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 52.0), whole brain E14.5 (RPKM 41.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D2; 10 65.26 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (117051046..117060412, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (117215141..117224507, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Findings indicate that the YEATS domain-containing protein 4 (Yeats4)-LIM domain transcription factor LMO4 (Lmo4) axis is required for Innate lymphoid cells (ILCs) lineage commitment.
Title: Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236462

AW743864 (e-PCR)
- UniSTS:208612

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables lysine-acetylated histone binding	ISO Inferred from Sequence Orthology more info
enables modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of apoptotic process	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of double-strand break repair	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of NuA4 histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NuA4 histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
part_of nucleosome	NAS Non-traceable Author Statement more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: YEATS domain-containing protein 4

Names: glioma-amplified sequence 41 homolog; glioma-amplified sequence-41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026570.4 → NP_080846.1 YEATS domain-containing protein 4

See identical proteins and their annotated locations for NP_080846.1

Status: VALIDATED

Source sequence(s)

AK010522, CJ213771

Consensus CDS

CCDS24191.1

UniProtKB/Swiss-Prot

Q9CR11, Q9CW86

Related

ENSMUSP00000020382.7, ENSMUST00000020382.8

Conserved Domains (1) summary

cd16909
Location:19 → 155

YEATS_GAS41_like; YEATS domain found in YEATS domain-containing protein 4 and similar proteins