ERVK-6 endogenous retrovirus group K member 6, envelope [Homo sapiens (human)] - Gene

Summary

Official Symbol: ERVK-6provided by HGNC
Official Full Name: endogenous retrovirus group K member 6, envelopeprovided by HGNC
Primary source: HGNC:HGNC:13915
See related: MIM:605626
Gene type: other
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: cORF; ERVK6; K-Rev; c-orf; envK2; HERV-K108; HERV-K(C7)
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Up-regulation of the endogenous retrovirus HERV-K initiates and sustains activation of the immune system and causes vascular changes associated with pulmonary arterial hypertension.
Title: Upregulation of Human Endogenous Retrovirus-K Is Linked to Immunity and Inflammation in Pulmonary Arterial Hypertension.
ERVK6 gene insertion polymorphisms are associated with lung cancer.
Title: Identification and association study with lung cancer for novel insertion polymorphisms of human endogenous retrovirus.
Here, it was shown that human endogenous retrovirus Rec can form a trimeric complex with TZFP and AR, and can relieve the TZFP-mediated repression of AR-induced transactivation.
Title: Human endogenous retrovirus protein Rec interacts with the testicular zinc-finger protein and androgen receptor.
ERVK6 translocates Env into the endoplasmic reticulum lumen.
Title: Human endogenous retrovirus HERV-K(HML-2) encodes a stable signal peptide with biological properties distinct from Rec.
HERV-K rec has a role in disturbed germ cell development
Title: Human endogenous retrovirus rec interferes with germ cell development in mice and may cause carcinoma in situ, the predecessor lesion of germ cell tumors.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA stem-loop binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA-DNA hybrid ribonuclease activity	IEA Inferred from Electronic Annotation more info
enables RNA-directed DNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA integration	IEA Inferred from Electronic Annotation more info
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA synthesis involved in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA-templated DNA replication	IEA Inferred from Electronic Annotation more info
involved_in RNA-templated DNA biosynthetic process	IEA Inferred from Electronic Annotation more info

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The following Reference Sequences have been suppressed. Explain

NM_001007236.1: Suppressed sequence

Description

NM_001007236.1: This RefSeq was permanently discontinued as it represents an expressed retrovirus and is considered out of scope.

Nucleotide		Protein
Heading	Accession and Version	Protein