Dusp10 dual specificity phosphatase 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dusp10provided by MGI
Official Full Name: dual specificity phosphatase 10provided by MGI
Primary source: MGI:MGI:1927070
See related: Ensembl:ENSMUSG00000039384 AllianceGenome:MGI:1927070
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MKP5; MKP-5; 2610306G15Rik
Summary: Enables MAP kinase phosphatase activity. Involved in several processes, including negative regulation of ERK1 and ERK2 cascade; negative regulation of epithelial cell migration; and negative regulation of epithelium regeneration. Acts upstream of or within several processes, including negative regulation of protein kinase activity; negative regulation of respiratory burst involved in inflammatory response; and oligodendrocyte differentiation. Predicted to be located in Golgi apparatus; cytosol; and nuclear speck. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human DUSP10 (dual specificity phosphatase 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in thymus adult (RPKM 37.9), testis adult (RPKM 13.3) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 88.2 cM; 1 H5

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (183766575..183807833)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (184034381..184075636)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitogen activated protein kinase phosphatase 5 alleviates liver ischemia-reperfusion injury by inhibiting TAK1/JNK/p38 pathway.
Title: Mitogen activated protein kinase phosphatase 5 alleviates liver ischemia-reperfusion injury by inhibiting TAK1/JNK/p38 pathway.
DUSP10 alleviates ischemic stroke-induced neuronal damage by restricting p38/JNK pathway.
Title: DUSP10 alleviates ischemic stroke-induced neuronal damage by restricting p38/JNK pathway.
MAP Kinase Phosphatase-5 Deficiency Protects Against Pressure Overload-Induced Cardiac Fibrosis.
Title: MAP Kinase Phosphatase-5 Deficiency Protects Against Pressure Overload-Induced Cardiac Fibrosis.
Bone marrow macrophage-derived exosomal miR-143-5p contributes to insulin resistance in hepatocytes by repressing MKP5.
Title: Bone marrow macrophage-derived exosomal miR-143-5p contributes to insulin resistance in hepatocytes by repressing MKP5.
De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes.
Title: De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes.
MKP-5 Relieves Lipotoxicity-Induced Islet beta-Cell Dysfunction and Apoptosis via Regulation of Autophagy.
Title: MKP-5 Relieves Lipotoxicity-Induced Islet β-Cell Dysfunction and Apoptosis via Regulation of Autophagy.
The Role of MKP-5 in Adipocyte-Macrophage Interactions during Obesity.
Title: The Role of MKP-5 in Adipocyte-Macrophage Interactions during Obesity.
High DUSP10 expression is associated with pulmonary fibrosis.
Title: Role of dual-specificity protein phosphatase DUSP10/MKP-5 in pulmonary fibrosis.
MKP-5 negatively regulates apoptotic signaling in skeletal muscle. During regeneration, MKP-5 downregulation contributes to myofiber survival.
Title: Loss of MKP-5 promotes myofiber survival by activating STAT3/Bcl-2 signaling during regenerative myogenesis.
MKP-5-mediated regulation of JNK negatively regulates phosphorylation of GRAB, which subsequently controls secretion of IL-6
Title: A Phosphoproteomic Screen Identifies a Guanine Nucleotide Exchange Factor for Rab3A Protein as a Mitogen-activated Protein (MAP) Kinase Phosphatase-5-regulated MAP Kinase Target in Interleukin 6 (IL-6) Secretion and Myogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI158871 (e-PCR)
- UniSTS:178545

Dusp10 (e-PCR), detects polymorphism
- UniSTS:506863

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables JUN kinase binding	ISO Inferred from Sequence Orthology more info
enables MAP kinase phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase phosphatase activity	ISO Inferred from Sequence Orthology more info
enables MAP kinase tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase tyrosine/serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase p38 binding	ISO Inferred from Sequence Orthology more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine/serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of JUN kinase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of JUN kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epithelium regeneration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein kinase activity by regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of respiratory burst involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of stress-activated MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-threonine dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of regulatory T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of adaptive immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of brown fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of stress-activated MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dual specificity protein phosphatase 10

Names: MAP kinase phosphatase 5; mitogen-activated protein kinase phosphatase 5

NP_071302.2

EC 3.1.3.16

EC 3.1.3.48

XP_006497251.1

EC 3.1.3.16

EC 3.1.3.48

XP_006497252.1

EC 3.1.3.16

EC 3.1.3.48

XP_036008612.1

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022019.6 → NP_071302.2 dual specificity protein phosphatase 10

See identical proteins and their annotated locations for NP_071302.2

Status: VALIDATED

Source sequence(s)

AK142568, BY283666, CK626309

Consensus CDS

CCDS15591.1

UniProtKB/Swiss-Prot

Q8R3L3, Q9CZY9, Q9ESS0

Related

ENSMUSP00000045838.8, ENSMUST00000048655.8

Conserved Domains (2) summary

cd01446
Location:150 → 285

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14567
Location:323 → 474

DSP_DUSP10; dual specificity phosphatase domain of dual specificity protein phosphatase 10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

183766575..183807833

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152719.1 → XP_036008612.1 dual specificity protein phosphatase 10 isoform X2

Conserved Domains (1) summary

cd01446
Location:150 → 272

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
XM_006497189.3 → XP_006497252.1 dual specificity protein phosphatase 10 isoform X1

See identical proteins and their annotated locations for XP_006497252.1

UniProtKB/Swiss-Prot

Q8R3L3, Q9CZY9, Q9ESS0

Conserved Domains (2) summary

cd01446
Location:150 → 285

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14567
Location:323 → 474

DSP_DUSP10; dual specificity phosphatase domain of dual specificity protein phosphatase 10
XM_006497188.3 → XP_006497251.1 dual specificity protein phosphatase 10 isoform X1

See identical proteins and their annotated locations for XP_006497251.1

UniProtKB/Swiss-Prot

Q8R3L3, Q9CZY9, Q9ESS0

Conserved Domains (2) summary

cd01446
Location:150 → 285

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14567
Location:323 → 474

DSP_DUSP10; dual specificity phosphatase domain of dual specificity protein phosphatase 10