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Zfp296 zinc finger protein 296 [ Mus musculus (house mouse) ]

Gene ID: 63872, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp296provided by MGI
Official Full Name
zinc finger protein 296provided by MGI
Primary source
MGI:MGI:1926956
See related
Ensembl:ENSMUSG00000011267 AllianceGenome:MGI:1926956
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf296; 2210018A16Rik
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II and spermatogenesis. Located in nucleus. Is expressed in several structures, including bone marrow; brain; early conceptus; gonad; and ureter. Orthologous to human ZNF296 (zinc finger protein 296). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 14.0), ovary adult (RPKM 6.4) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A3; 7 9.93 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19311212..19314581)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19577287..19580656)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 37 Neighboring gene STARR-seq mESC enhancer starr_18207 Neighboring gene gem nuclear organelle associated protein 7 Neighboring gene CLK4-associating serine/arginine rich protein Neighboring gene avian reticuloendotheliosis viral (v-rel) oncogene related B Neighboring gene STARR-positive B cell enhancer ABC_E1720

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NuRD-interacting protein ZFP296 regulates genome-wide NuRD localization and differentiation of mouse embryonic stem cells. Kloet SL, et al. Nat Commun, 2018 Nov 2. PMID 30389936, Free PMC Article
  2. Tracing the transitions from pluripotency to germ cell fate with CRISPR screening. Hackett JA, et al. Nat Commun, 2018 Oct 16. PMID 30327475, Free PMC Article
  3. Zfp296 is a novel Klf4-interacting protein and functions as a negative regulator. Fujii Y, et al. Biochem Biophys Res Commun, 2013 Nov 15. PMID 24161396
  4. Cloning, structure, expression analysis, and assignment to mouse chromosome 7 of the gene Zfp296 encoding a zinc finger protein. Dear TN. Mamm Genome, 2000 Nov. PMID 11063263
  5. Retinal transcriptome of neonatal mice after optic nerve injury. Yao SQ, et al. PLoS One, 2023. PMID 37252932, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The stem cell transcription factor ZFP296 transforms NIH3T3 cells and promotes anchorage-independent growth of cancer cells.
    Title: The stem cell transcription factor ZFP296 transforms NIH3T3 cells and promotes anchorage-independent growth of cancer cells.
  2. Zfp296 knockout enhances chromatin accessibility and induces a unique state of pluripotency in embryonic stem cells.
    Title: Zfp296 knockout enhances chromatin accessibility and induces a unique state of pluripotency in embryonic stem cells.
  3. The results demonstrate that Zfp296 is a component of heterochromatin that affects embryonic development by negatively regulating H3K9 methylation.
    Title: Zfp296 negatively regulates H3K9 methylation in embryonic development as a component of heterochromatin.
  4. ZFP296 was identified as an embryonic stem cell-specific NuRD interactor that also interacts with the SIN3A complex.
    Title: NuRD-interacting protein ZFP296 regulates genome-wide NuRD localization and differentiation of mouse embryonic stem cells.
  5. Zfp296 is a key component of an expanded primordial germ cells gene regulatory network.
    Title: Tracing the transitions from pluripotency to germ cell fate with CRISPR screening.
  6. These findings suggest that Zfp296 is a functional regulator of Klf4 in embryonic stem cells.
    Title: Zfp296 is a novel Klf4-interacting protein and functions as a negative regulator.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of dendrite development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 296
Names
hepatocellular carcinoma-associated antigen MHCA108

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022409.2 → NP_071854.2  zinc finger protein 296

    Status: VALIDATED

    Source sequence(s)
    AK008748, BE634620, BE635089, DV647330
    Consensus CDS
    CCDS52060.1
    UniProtKB/Swiss-Prot
    E9Q6W4, Q4FZI6, Q9D7X0, Q9EPM0
    Related
    ENSMUSP00000104093.2, ENSMUST00000108453.2
    Conserved Domains (5) summary
    COG5048
    Location:361 → 410
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:362 → 382
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:214 → 234
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:361 → 382
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:226 → 251
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    19311212..19314581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q6W4.1 GenPept UniProtKB/Swiss-Prot:E9Q6W4

Gene LinkOut

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