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Fn3k fructosamine 3 kinase [ Mus musculus (house mouse) ]

Gene ID: 63828, updated on 21-Apr-2024

Summary

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Official Symbol
Fn3kprovided by MGI
Official Full Name
fructosamine 3 kinaseprovided by MGI
Primary source
MGI:MGI:1926834
See related
Ensembl:ENSMUSG00000025175 AllianceGenome:MGI:1926834
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310074G21Rik
Summary
Enables protein-fructosamine 3-kinase activity. Involved in protein deglycation. Acts upstream of or within fructosamine metabolic process. Predicted to be located in cytosol. Orthologous to human FN3K (fructosamine 3 kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14.5 (RPKM 11.4), liver E14 (RPKM 10.9) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E2; 11 85.38 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (121325779..121341316)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (121434953..121450490)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Rab40B, member RAS oncogene family Neighboring gene microRNA 7236 Neighboring gene STARR-positive B cell enhancer mm9_chr11:121282511-121282812 Neighboring gene fructosamine 3 kinase related protein Neighboring gene STARR-positive B cell enhancer mm9_chr11:121312999-121313300 Neighboring gene tubulin-specific chaperone d Neighboring gene STARR-seq mESC enhancer starr_31381 Neighboring gene zinc finger protein 750 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:121420970-121421165 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 Neighboring gene STARR-seq mESC enhancer starr_31382 Neighboring gene predicted gene, 53659

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Evidence That Differences in Fructosamine-3-Kinase Activity May Be Associated With the Glycation Gap in Human Diabetes. Dunmore SJ, et al. Diabetes, 2018 Jan. PMID 29066600
  2. Effects of fructosamine-3-kinase deficiency on function and survival of mouse pancreatic islets after prolonged culture in high glucose or ribose concentrations. Pascal SM, et al. Am J Physiol Endocrinol Metab, 2010 Mar. PMID 20009024
  3. Increased protein glycation in fructosamine 3-kinase-deficient mice. Veiga da-Cunha M, et al. Biochem J, 2006 Oct 15. PMID 16819943, Free PMC Article
  4. The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase. Sanghvi VR, et al. Cell, 2019 Aug 8. PMID 31398338, Free PMC Article
  5. Tissue distribution and evolution of fructosamine 3-kinase and fructosamine 3-kinase-related protein. Delplanque J, et al. J Biol Chem, 2004 Nov 5. PMID 15331600

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FN3K is a targetable modulator of NRF2 activity in cancer.
    Title: The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase.
  2. Data conclude that FN3K may play a key role in the GGap and thus diabetes complications such that FN3K may be a potential predictor of the risk of diabetes complications. Pharmacological modifications of its activity may provide a novel approach to their prevention.
    Title: Evidence That Differences in Fructosamine-3-Kinase Activity May Be Associated With the Glycation Gap in Human Diabetes.
  3. We conclude that, despite its ability to reduce the glycation of intracellular islet proteins, FN3K is neither required for the maintenance of beta-cell survival and function under control conditions.
    Title: Effects of fructosamine-3-kinase deficiency on function and survival of mouse pancreatic islets after prolonged culture in high glucose or ribose concentrations.
  4. These data indicate that FN3K serves as a protein repair enzyme and also in the metabolism of endogenously produced free fructose-epsilon-lysine.
    Title: Increased protein glycation in fructosamine 3-kinase-deficient mice.
  5. fructosamine 3-kinase and fructosamine 3-kinase-related protein have roles in repairing damage caused by ribose 5-phosphate
    Title: Tissue distribution and evolution of fructosamine 3-kinase and fructosamine 3-kinase-related protein.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-fructosamine 3-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-fructosamine 3-kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein-fructosamine 3-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-ribulosamine 3-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fructosamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fructosamine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein deglycation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein deglycation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
fructosamine-3-kinase
Names
protein-psicosamine 3-kinase FN3K
protein-ribulosamine 3-kinase FN3K
NP_001033788.1
NP_071297.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038699.2 → NP_001033788.1  fructosamine-3-kinase isoform b

    See identical proteins and their annotated locations for NP_001033788.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site and segment for its 3' UTR, compared to variant 1. The resulting protein (isoform b) has a shorter and distinct C-terminus when it is compared to isoform a.
    Source sequence(s)
    BC054374, BY142714
    Consensus CDS
    CCDS25777.1
    UniProtKB/TrEMBL
    Q7TQJ3
    Related
    ENSMUSP00000099303.4, ENSMUST00000103014.4
    Conserved Domains (1) summary
    cl21453
    Location:3 → 157
    PKc_like; Protein Kinases, catalytic domain

  2. NM_022014.4 → NP_071297.1  fructosamine-3-kinase isoform a

    See identical proteins and their annotated locations for NP_071297.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform a).
    Source sequence(s)
    AA058133, AI464555, BU571242, BY142714
    Consensus CDS
    CCDS25776.1
    UniProtKB/Swiss-Prot
    Q9D6N6, Q9ER35
    Related
    ENSMUSP00000026175.3, ENSMUST00000026175.9
    Conserved Domains (1) summary
    cl21453
    Location:3 → 309
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    121325779..121341316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ER35.1 GenPept UniProtKB/Swiss-Prot:Q9ER35

Gene LinkOut

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