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Gbp11 guanylate binding protein 11 [ Mus musculus (house mouse) ]

Gene ID: 634650, updated on 8-Feb-2024

Summary

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Official Symbol
Gbp11provided by MGI
Official Full Name
guanylate binding protein 11provided by MGI
Primary source
MGI:MGI:3646307
See related
Ensembl:ENSMUSG00000092021 AllianceGenome:MGI:3646307
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm7141; EG634650
Summary
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in cellular response to interferon-gamma; defense response to Gram-positive bacterium; and defense response to protozoan. Predicted to be active in cytoplasmic vesicle. Orthologous to human GBP6 (guanylate binding protein family member 6). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression
Broad expression in liver adult (RPKM 2.1), thymus adult (RPKM 2.0) and 22 other tissues See more
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Genomic context

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Location:
5 E5; 5 50.68 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (105470892..105494342, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (105323026..105346476, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31785 Neighboring gene guanylate-binding protein 10 Neighboring gene STARR-seq mESC enhancer starr_13849 Neighboring gene guanylate binding protein 6 Neighboring gene RIKEN cDNA 4930542N06 gene Neighboring gene STARR-positive B cell enhancer ABC_E8067 Neighboring gene predicted gene, 26519 Neighboring gene predicted gene, 32051

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Clone Names

  • MGC117932

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to type II interferon IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to protozoan IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
guanylate binding protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039647.3 → NP_001034736.3  guanylate binding protein 11

    See identical proteins and their annotated locations for NP_001034736.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the functional non-reference strain allele and encodes the full-length protein.
    Source sequence(s)
    BC111039, BI655333
    UniProtKB/TrEMBL
    Q2TA93
    Conserved Domains (3) summary
    pfam02841
    Location:281 → 575
    GBP_C; Guanylate-binding protein, C-terminal domain
    pfam02263
    Location:16 → 279
    GBP; Guanylate-binding protein, N-terminal domain
    cd16269
    Location:287 → 575
    GBP_C; Guanylate-binding protein, C-terminal domain

RNA

  1. NR_132129.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, non-coding) includes a premature stop codon and represents the non-functional allele, as in the C57BL/6 reference genome.
    Source sequence(s)
    AC113980, BF470780
    Related
    ENSMUST00000100960.11

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    105470892..105494342 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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