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Ak9 adenylate kinase 9 [ Mus musculus (house mouse) ]

Gene ID: 633979, updated on 21-Apr-2024

Summary

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Official Symbol
Ak9provided by MGI
Official Full Name
adenylate kinase 9provided by MGI
Primary source
MGI:MGI:2685080
See related
Ensembl:ENSMUSG00000091415 AllianceGenome:MGI:2685080
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Akd1; Akd2; Gm234; Gm7127
Summary
Predicted to enable adenylate kinase activity and nucleoside diphosphate kinase activity. Predicted to be involved in nucleotide metabolic process. Predicted to be located in nuclear membrane and nucleoplasm. Predicted to be active in mitochondrion. Is expressed in brain; lung; and rib. Orthologous to human AK9 (adenylate kinase 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 5.1) See more
Orthologs
human all
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Genomic context

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Location:
10 B1; 10 22.23 cM
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (41179433..41309565)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (41303432..41433569)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32411 Neighboring gene FIG4 phosphoinositide 5-phosphatase Neighboring gene predicted gene, 25526 Neighboring gene STARR-seq mESC enhancer starr_26444 Neighboring gene STARR-seq mESC enhancer starr_26445 Neighboring gene STARR-seq mESC enhancer starr_26446 Neighboring gene STARR-seq mESC enhancer starr_26447 Neighboring gene sperm specific antigen 2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8331 Neighboring gene STARR-seq mESC enhancer starr_26448 Neighboring gene ClpB caseinolytic peptidase B homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_26449 Neighboring gene predicted gene, 25626 Neighboring gene STARR-seq mESC enhancer starr_26450 Neighboring gene STARR-positive B cell enhancer ABC_E2321 Neighboring gene predicted gene, 53622 Neighboring gene zinc finger and BTB domain containing 24

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
  5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A role for mutations in AK9 and other genes affecting ependymal cells in idiopathic normal pressure hydrocephalus.
    Title: A role for mutations in AK9 and other genes affecting ependymal cells in idiopathic normal pressure hydrocephalus.
  2. Adenylate kinase 9 is essential for sperm function and male fertility in mammals.
    Title: Adenylate kinase 9 is essential for sperm function and male fertility in mammals.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables adenylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleoside diphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleoside diphosphate kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleoside monophosphate kinase activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
adenylate kinase 9
Names
adenylate kinase domain containing 1
adenylate kinase domain containing 2
NP_001357742.1
XP_006513002.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370813.1 → NP_001357742.1  adenylate kinase 9

    Status: VALIDATED

    Source sequence(s)
    AC122332, AC153360
    UniProtKB/TrEMBL
    G3UYQ4
    Related
    ENSMUSP00000134177.3, ENSMUST00000173494.4
    Conserved Domains (3) summary
    cd01428
    Location:1381 → 1553
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:34 → 286
    adk; adenylate kinase
    cl00909
    Location:926 → 956
    Ribosomal_L24e_L24; Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    41179433..41309565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512939.4 → XP_006513002.1  adenylate kinase 9 isoform X1

    See identical proteins and their annotated locations for XP_006513002.1

    UniProtKB/TrEMBL
    G3UYQ4
    Conserved Domains (3) summary
    cd01428
    Location:1381 → 1553
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:34 → 286
    adk; adenylate kinase
    cl00909
    Location:926 → 956
    Ribosomal_L24e_L24; Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor ...
Nucleotide Protein Strain
Heading Accession and Version

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