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Fer1l6 fer-1 like family member 6 [ Mus musculus (house mouse) ]

Gene ID: 631797, updated on 5-Mar-2024

Summary

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Official Symbol
Fer1l6provided by MGI
Official Full Name
fer-1 like family member 6provided by MGI
Primary source
MGI:MGI:3645398
See related
Ensembl:ENSMUSG00000037106 AllianceGenome:MGI:3645398
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EG631797
Summary
Acts upstream of or within response to bacterium. Orthologous to human FER1L6 (fer-1 like family member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 6.1), large intestine adult (RPKM 2.6) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 D1; 15 24.88 cM
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (58381897..58536936)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (58510048..58665087)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53238 Neighboring gene annexin A13 Neighboring gene STARR-positive B cell enhancer ABC_E7369 Neighboring gene STARR-seq mESC enhancer starr_38755 Neighboring gene family with sequence similarity 91, member A1 Neighboring gene STARR-seq mESC enhancer starr_38756 Neighboring gene STARR-seq mESC enhancer starr_38757 Neighboring gene STARR-seq mESC enhancer starr_38758 Neighboring gene predicted gene, 36451 Neighboring gene STARR-seq mESC enhancer starr_38759 Neighboring gene predicted gene, 41329 Neighboring gene transmembrane protein 65 Neighboring gene predicted gene, 24041

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Testis-enriched ferlin, FER1L5, is required for Ca(2+)-activated acrosome reaction and male fertility. Morohoshi A, et al. Sci Adv, 2023 Jan 25. PMID 36696506, Free PMC Article
  2. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in plasma membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
fer-1-like protein 6
Names
fer-1-like 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370912.1 → NP_001357841.1  fer-1-like protein 6

    Status: VALIDATED

    Source sequence(s)
    AC107742, AC107775, AC163393
    UniProtKB/TrEMBL
    E0CZ42
    Related
    ENSMUSP00000125718.2, ENSMUST00000161028.2
    Conserved Domains (8) summary
    cd04011
    Location:89 → 198
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:838 → 971
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:253 → 404
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1372 → 1495
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08374
    Location:1612 → 1745
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    pfam08150
    Location:725 → 796
    FerB; FerB (NUC096) domain
    pfam08151
    Location:196 → 245
    FerI; FerI (NUC094) domain
    pfam16165
    Location:1756 → 1868
    Ferlin_C; Ferlin C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    58381897..58536936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521609.3 → XP_006521672.2  fer-1-like protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006521672.2

    UniProtKB/TrEMBL
    E0CZ42
    Conserved Domains (8) summary
    cd04011
    Location:79 → 188
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:828 → 961
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:243 → 394
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1362 → 1485
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08374
    Location:1602 → 1735
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    pfam08150
    Location:715 → 786
    FerB; FerB (NUC096) domain
    pfam08151
    Location:186 → 235
    FerI; FerI (NUC094) domain
    pfam16165
    Location:1746 → 1858
    Ferlin_C; Ferlin C-terminus

  2. XM_006521610.5 → XP_006521673.1  fer-1-like protein 6 isoform X2

    See identical proteins and their annotated locations for XP_006521673.1

    Conserved Domains (4) summary
    cd04037
    Location:485 → 608
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08374
    Location:725 → 858
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    pfam16165
    Location:869 → 981
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1 → 84
    C2; C2 domain
Nucleotide Protein
Heading Accession and Version

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