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Sult2a6 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 6 [ Mus musculus (house mouse) ]

Gene ID: 629219, updated on 11-Apr-2024

Summary

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Official Symbol
Sult2a6provided by MGI
Official Full Name
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 6provided by MGI
Primary source
MGI:MGI:3648915
See related
Ensembl:ENSMUSG00000070810 AllianceGenome:MGI:3648915
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ST2A6; BAST I; Gm6957; EG629219
Summary
Predicted to enable 3'-phosphoadenosine 5'-phosphosulfate binding activity and sulfotransferase activity. Predicted to be involved in several processes, including 3'-phosphoadenosine 5'-phosphosulfate metabolic process; ethanol catabolic process; and thyroid hormone metabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human SULT2A1 (sulfotransferase family 2A member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
7 A1; 7 8.15 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (13956328..13988795, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (14222403..14254870, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18089 Neighboring gene transmembrane protein 167, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_18090 Neighboring gene STARR-seq mESC enhancer starr_18091 Neighboring gene sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 3 Neighboring gene STARR-seq mESC enhancer starr_18094 Neighboring gene STARR-seq mESC enhancer starr_18095 Neighboring gene STARR-seq mESC enhancer starr_18096 Neighboring gene STARR-seq mESC enhancer starr_18097 Neighboring gene STARR-seq mESC enhancer starr_18098 Neighboring gene RNA polymerase II associated protein 3, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_18099 Neighboring gene PHD finger protein 20, pseudogene Neighboring gene mitochondrial ribosomal protein S36, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Age- and sex-dependent expression of multiple murine hepatic hydroxysteroid sulfotransferase (SULT2A) genes. Kocarek TA, et al. Biochem Pharmacol, 2008 Oct 15. PMID 18725207, Free PMC Article
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-phosphoadenosine 5'-phosphosulfate binding ISO
Inferred from Sequence Orthology
more info
  
enables alcohol sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables bile-salt sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables steroid sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ethanol catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in steroid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in sulfation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sulfation ISO
Inferred from Sequence Orthology
more info
  
involved_in thyroid hormone metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sulfotransferase 2A6
Names
bile acid:3'phosphoadenosine-5'phosphosulfate:sulfotransferase I
sulfotransferase family 2A member 1 family member
NP_001074794.1
XP_006540331.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081325.2 → NP_001074794.1  sulfotransferase 2A6

    See identical proteins and their annotated locations for NP_001074794.1

    Status: VALIDATED

    Source sequence(s)
    AC098714
    Consensus CDS
    CCDS39773.1
    UniProtKB/Swiss-Prot
    B2RVI8
    Related
    ENSMUSP00000075884.6, ENSMUST00000076576.7
    Conserved Domains (1) summary
    pfam00685
    Location:34 → 278
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    13956328..13988795 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540268.1 → XP_006540331.1  sulfotransferase 2A6 isoform X1

    Conserved Domains (1) summary
    pfam00685
    Location:34 → 167
    Sulfotransfer_1; Sulfotransferase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2RVI8.1 GenPept UniProtKB/Swiss-Prot:B2RVI8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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