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Syndig1l synapse differentiation inducing 1 like [ Mus musculus (house mouse) ]

Gene ID: 627191, updated on 11-Apr-2024

Summary

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Official Symbol
Syndig1lprovided by MGI
Official Full Name
synapse differentiation inducing 1 likeprovided by MGI
Primary source
MGI:MGI:2685107
See related
Ensembl:ENSMUSG00000071234 AllianceGenome:MGI:2685107
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DSPC1; Gm261; SynDIG2; Tmem90a
Summary
Located in Golgi apparatus. Is expressed in male reproductive gland or organ; nervous system; and retina layer. Orthologous to human SYNDIG1L (synapse differentiation inducing 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 5.4), testis adult (RPKM 4.8) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 D1; 12 39.33 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84724051..84745720, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84677277..84698947, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32746 Neighboring gene ATP-binding cassette, sub-family D member 4 Neighboring gene STARR-seq mESC enhancer starr_32747 Neighboring gene STARR-seq mESC enhancer starr_32748 Neighboring gene vertebrae development associated Neighboring gene STARR-seq mESC enhancer starr_32749 Neighboring gene STARR-positive B cell enhancer mm9_chr12:86096267-86096568 Neighboring gene NPC intracellular cholesterol transporter 2 Neighboring gene iron-sulfur cluster assembly 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Capucin does not modify the toxicity of a mutant Huntingtin fragment in vivo. Galvan L, et al. Neurobiol Aging, 2012 Aug. PMID 22365050
  2. Capucin: a novel striatal marker down-regulated in rodent models of Huntington disease. de Chaldée M, et al. Genomics, 2006 Feb. PMID 16359841
  3. SynDIG1: an activity-regulated, AMPA- receptor-interacting transmembrane protein that regulates excitatory synapse development. Kalashnikova E, et al. Neuron, 2010 Jan 14. PMID 20152115, Free PMC Article
  4. MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons. Kay JN, et al. Nature, 2012 Mar 11. PMID 22407321, Free PMC Article
  5. The dispanins: a novel gene family of ancient origin that contains 14 human members. Sällman Almén M, et al. PLoS One, 2012. PMID 22363774, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
synapse differentiation-inducing gene protein 1-like
Names
capucin
caudate and putamen-enriched protein
dispanin subfamily C member 1
synapse differentiation-induced protein 2
transmembrane protein 90a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033334.2 → NP_001028506.1  synapse differentiation-inducing gene protein 1-like

    See identical proteins and their annotated locations for NP_001028506.1

    Status: VALIDATED

    Source sequence(s)
    AC159641
    Consensus CDS
    CCDS26049.1
    UniProtKB/Swiss-Prot
    Q3USQ7
    UniProtKB/TrEMBL
    B2RRM8
    Related
    ENSMUSP00000093206.3, ENSMUST00000095550.4
    Conserved Domains (1) summary
    pfam04505
    Location:156 → 216
    CD225; Interferon-induced transmembrane protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    84724051..84745720 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246834.2 → XP_030102694.1  synapse differentiation-inducing gene protein 1-like isoform X1

  2. XM_030246836.2 → XP_030102696.1  synapse differentiation-inducing gene protein 1-like isoform X1

  3. XM_030246835.2 → XP_030102695.1  synapse differentiation-inducing gene protein 1-like isoform X1

  4. XM_006516125.4 → XP_006516188.1  synapse differentiation-inducing gene protein 1-like isoform X2

    See identical proteins and their annotated locations for XP_006516188.1

    UniProtKB/Swiss-Prot
    Q3USQ7
    UniProtKB/TrEMBL
    B2RRM8
    Related
    ENSMUSP00000152374.2, ENSMUST00000222422.2
    Conserved Domains (1) summary
    pfam04505
    Location:156 → 216
    CD225; Interferon-induced transmembrane protein

  5. XM_006516124.4 → XP_006516187.1  synapse differentiation-inducing gene protein 1-like isoform X2

    See identical proteins and their annotated locations for XP_006516187.1

    UniProtKB/Swiss-Prot
    Q3USQ7
    UniProtKB/TrEMBL
    B2RRM8
    Conserved Domains (1) summary
    pfam04505
    Location:156 → 216
    CD225; Interferon-induced transmembrane protein

  6. XM_036157555.1 → XP_036013448.1  synapse differentiation-inducing gene protein 1-like isoform X2

    UniProtKB/Swiss-Prot
    Q3USQ7
    UniProtKB/TrEMBL
    B2RRM8
    Conserved Domains (1) summary
    pfam04505
    Location:156 → 216
    CD225; Interferon-induced transmembrane protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3USQ7.1 GenPept UniProtKB/Swiss-Prot:Q3USQ7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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