Defa28 defensin, alpha, 28 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Defa28provided by MGI
Official Full Name: defensin, alpha, 28provided by MGI
Primary source: MGI:MGI:3646688
See related: Ensembl:ENSMUSG00000074434 AllianceGenome:MGI:3646688
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm6696; EG626682
Summary: Predicted to enable protein homodimerization activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; defense response to other organism; and positive regulation of membrane permeability. Predicted to be located in intracellular membrane-bounded organelle and midbody. Predicted to be active in extracellular space. Orthologous to several human genes including DEFA3 (defensin alpha 3) and DEFA6 (defensin alpha 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 179.2), duodenum adult (RPKM 131.3) and 1 other tissue See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 8 A2; 8 10.35 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (22072976..22073883)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (21582960..21583867)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables pore-forming activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IBA Inferred from Biological aspect of Ancestor more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-negative bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in disruption of plasma membrane integrity in another organism	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response in mucosa	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: defensin-6

Names: novel defensin-related cryptidin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177523.1 → NP_001170994.1 defensin-6 precursor

Status: VALIDATED

Source sequence(s)

AC133094

Consensus CDS

CCDS52511.1

UniProtKB/TrEMBL

D3Z1V9

Related

ENSMUSP00000096486.4, ENSMUST00000098887.4

Conserved Domains (2) summary

pfam00323
Location:66 → 93

Defensin_1; Mammalian defensin

pfam00879
Location:15 → 51

Defensin_propep; Defensin propeptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

22072976..22073883

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017312929.1 → XP_017168418.1 defensin-6 isoform X1

UniProtKB/TrEMBL

V9GZ96

Conserved Domains (1) summary

pfam00879
Location:15 → 51

Defensin_propep; Defensin propeptide