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Slc38a6 solute carrier family 38, member 6 [ Mus musculus (house mouse) ]

Gene ID: 625098, updated on 11-Apr-2024

Summary

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Official Symbol
Slc38a6provided by MGI
Official Full Name
solute carrier family 38, member 6provided by MGI
Primary source
MGI:MGI:3648156
See related
Ensembl:ENSMUSG00000044712 AllianceGenome:MGI:3648156
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EG625098
Summary
Predicted to enable L-glutamine transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport and glutamine transport. Located in plasma membrane. Is expressed in forelimb long bone. Orthologous to human SLC38A6 (solute carrier family 38 member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 3.8), placenta adult (RPKM 3.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 C3; 12 30.42 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (73333622..73408772)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (73286739..73361998)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene menage a trois 1 Neighboring gene STARR-positive B cell enhancer ABC_E7146 Neighboring gene nuclear transport factor 2 pseudogene Neighboring gene cytochrome c oxidase subunit 7A2, mitochondrial pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9148 Neighboring gene STARR-seq mESC enhancer starr_32467 Neighboring gene TRM5 tRNA methyltransferase 5 Neighboring gene STARR-seq mESC enhancer starr_32469 Neighboring gene RIKEN cDNA D830013O20 gene Neighboring gene predicted gene, 40442 Neighboring gene predicted gene, 33929

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SLC38A6 expression in macrophages exacerbates pulmonary inflammation. Peng Y, et al. Respir Res, 2023 Jan 27. PMID 36707853, Free PMC Article
  2. Histological analysis of SLC38A6 (SNAT6) expression in mouse brain shows selective expression in excitatory neurons with high expression in the synapses. Bagchi S, et al. PLoS One, 2014. PMID 24752331, Free PMC Article
  3. The evolutionary history and tissue mapping of amino acid transporters belonging to solute carrier families SLC32, SLC36, and SLC38. Sundberg BE, et al. J Mol Neurosci, 2008 Jun. PMID 18418736
  4. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLC38A6 expression in macrophages exacerbates pulmonary inflammation.
    Title: SLC38A6 expression in macrophages exacerbates pulmonary inflammation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-glutamate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-glutamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-glutamine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in glutamine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 38 member 6
Names
Na(+)-coupled neutral amino acid transporter 6
amino acid transporter SLC38A6
probable sodium-coupled neutral amino acid transporter 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037717.3 → NP_001032806.2  solute carrier family 38 member 6

    See identical proteins and their annotated locations for NP_001032806.2

    Status: VALIDATED

    Source sequence(s)
    AC159813
    Consensus CDS
    CCDS49088.1
    UniProtKB/Swiss-Prot
    B2RXN5, G3UVW3
    Related
    ENSMUSP00000120810.2, ENSMUST00000140523.8
    Conserved Domains (2) summary
    COG0814
    Location:45 → 452
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    cl00456
    Location:45 → 452
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    73333622..73408772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244154.4 → XP_011242456.1  solute carrier family 38 member 6 isoform X1

    Conserved Domains (1) summary
    cl00456
    Location:45 → 430
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. XM_036157553.1 → XP_036013446.1  solute carrier family 38 member 6 isoform X3

    Conserved Domains (1) summary
    cl00456
    Location:35 → 365
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  3. XM_030246831.1 → XP_030102691.1  solute carrier family 38 member 6 isoform X4

    Conserved Domains (1) summary
    cl00456
    Location:1 → 316
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  4. XM_017315147.2 → XP_017170636.1  solute carrier family 38 member 6 isoform X4

    Conserved Domains (1) summary
    cl00456
    Location:1 → 316
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  5. XM_036157554.1 → XP_036013447.1  solute carrier family 38 member 6 isoform X3

    Conserved Domains (1) summary
    cl00456
    Location:35 → 365
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  6. XM_006516118.4 → XP_006516181.1  solute carrier family 38 member 6 isoform X2

    Conserved Domains (1) summary
    cl00456
    Location:2 → 397
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  7. XM_030246832.2 → XP_030102692.1  solute carrier family 38 member 6 isoform X5

    Conserved Domains (1) summary
    cl00456
    Location:1 → 283
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RNA

  1. XR_381537.5 RNA Sequence

  2. XR_003950074.2 RNA Sequence

  3. XR_001780471.3 RNA Sequence

  4. XR_001780472.3 RNA Sequence

  5. XR_004937532.1 RNA Sequence

  6. XR_003950073.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G3UVW3.1 GenPept UniProtKB/Swiss-Prot:G3UVW3

Gene LinkOut

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