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BDKRB2 bradykinin receptor B2 [ Homo sapiens (human) ]

Gene ID: 624, updated on 11-Apr-2024

Summary

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Official Symbol
BDKRB2provided by HGNC
Official Full Name
bradykinin receptor B2provided by HGNC
Primary source
HGNC:HGNC:1030
See related
Ensembl:ENSG00000168398 MIM:113503; AllianceGenome:HGNC:1030
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B2R; BK2; BK-2; BKR2; BRB2
Summary
This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Bradykinin is released upon activation by pathophysiologic conditions such as trauma and inflammation, and binds to its kinin receptors, B1 and B2. The B2 receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. [provided by RefSeq, Apr 2020]
Expression
Broad expression in urinary bladder (RPKM 13.5), gall bladder (RPKM 13.3) and 16 other tissues See more
Orthologs
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Genomic context

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See BDKRB2 in Genome Data Viewer
Location:
14q32.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (96204839..96244164)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (90436088..90475413)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (96671176..96710501)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6051 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8981 Neighboring gene chromosome 14 open reading frame 132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96519945-96520444 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:96526720-96526873 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:96529045-96529222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8982 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:96552361-96553560 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_38841 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96560846-96561346 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96561347-96561847 Neighboring gene uncharacterized LOC124903374 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96563297-96563798 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96642023-96642523 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:96658061-96658668 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:96659886-96660494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:96660495-96661102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96661103-96661710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96661711-96662318 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96664109-96664715 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96670637-96671512 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:96697669-96697864 Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:96719533-96720042 Neighboring gene uncharacterized LOC124903375 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:96734992-96736191 Neighboring gene NANOG hESC enhancer GRCh37_chr14:96748657-96749197 Neighboring gene bradykinin receptor B1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_38870 Neighboring gene autophagy related 2B Neighboring gene uncharacterized LOC124903430

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Function and structure of bradykinin receptor 2 for drug discovery. Shen JK, et al. Acta Pharmacol Sin, 2023 Mar. PMID 36075965, Free PMC Article
  2. Association of Variants Near the Bradykinin Receptor B(2) Gene With Angioedema in Patients Taking ACE Inhibitors. Ghouse J, et al. J Am Coll Cardiol, 2021 Aug 17. PMID 34384552
  3. BDKRB2 is a novel EMT-related biomarker and predicts poor survival in glioma. Yang Y, et al. Aging (Albany NY), 2021 Mar 3. PMID 33686021, Free PMC Article
  4. Potentiation of B2 receptor signaling by AltB2R, a newly identified alternative protein encoded in the human bradykinin B2 receptor gene. Gagnon M, et al. J Biol Chem, 2021 Jan-Jun. PMID 33497625, Free PMC Article
  5. Polymorphism of the bradykinin type 2 receptor gene modulates blood pressure profile and microvascular function in prepubescent children. Souza LV, et al. Peptides, 2021 Mar. PMID 33412234

See all (232) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bradykinin receptor expression and bradykinin-mediated sensitization of human sensory neurons.
    Title: Bradykinin receptor expression and bradykinin-mediated sensitization of human sensory neurons.
  2. Function and structure of bradykinin receptor 2 for drug discovery.
    Title: Function and structure of bradykinin receptor 2 for drug discovery.
  3. The Role of Bradykinin Receptors in Hereditary Angioedema Due to C1-Inhibitor Deficiency.
    Title: The Role of Bradykinin Receptors in Hereditary Angioedema Due to C1-Inhibitor Deficiency.
  4. Cryo-EM structures of human bradykinin receptor-Gq proteins complexes.
    Title: Cryo-EM structures of human bradykinin receptor-G(q) proteins complexes.
  5. ACE2 internalization induced by a SARS-CoV-2 recombinant protein is modulated by angiotensin II type 1 and bradykinin 2 receptors.
    Title: ACE2 internalization induced by a SARS-CoV-2 recombinant protein is modulated by angiotensin II type 1 and bradykinin 2 receptors.
  6. Polymorphism of the bradykinin type 2 receptor gene modulates blood pressure profile and microvascular function in prepubescent children.
    Title: Polymorphism of the bradykinin type 2 receptor gene modulates blood pressure profile and microvascular function in prepubescent children.
  7. Association of Variants Near the Bradykinin Receptor B2 Gene With Angioedema in Patients Taking ACE Inhibitors.
    Title: Association of Variants Near the Bradykinin Receptor B(2) Gene With Angioedema in Patients Taking ACE Inhibitors.
  8. Potentiation of B2 receptor signaling by AltB2R, a newly identified alternative protein encoded in the human bradykinin B2 receptor gene.
    Title: Potentiation of B2 receptor signaling by AltB2R, a newly identified alternative protein encoded in the human bradykinin B2 receptor gene.
  9. BDKRB2 is a novel EMT-related biomarker and predicts poor survival in glioma.
    Title: BDKRB2 is a novel EMT-related biomarker and predicts poor survival in glioma.
  10. Down-regulation of B2R contributes to preeclampsia by inhibiting human trophoblast cell invasion and angiogenesis.
    Title: Down-regulation of B2R contributes to preeclampsia by inhibiting human trophoblast cell invasion and angiogenesis.
Submit: New GeneRIF Correction See all GeneRIFs (169)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of bradykinin receptor B2 (BDKRB2) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: BDKRB1

Homology

Clone Names

  • DKFZp686O088

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables bradykinin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables bradykinin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity TAS
Traceable Author Statement
more info
 PubMed 
enables protease binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables type 1 angiotensin receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in arachidonic acid secretion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in blood circulation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in inflammatory response IC
Inferred by Curator
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of vascular permeability IC
Inferred by Curator
more info
 PubMed 
involved_in regulation of vasoconstriction IC
Inferred by Curator
more info
 PubMed 
involved_in response to salt stress IEA
Inferred from Electronic Annotation
more info
  
involved_in smooth muscle contraction IC
Inferred by Curator
more info
 PubMed 
involved_in vasoconstriction IEA
Inferred from Electronic Annotation
more info
  
involved_in vasodilation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
B2 bradykinin receptor
Names
BK-2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000623.4 → NP_000614.1  B2 bradykinin receptor

    See identical proteins and their annotated locations for NP_000614.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL355102
    Consensus CDS
    CCDS9942.1
    UniProtKB/Swiss-Prot
    P30411
    UniProtKB/TrEMBL
    B4DRL4, Q68DM8
    Conserved Domains (1) summary
    cd15381
    Location:58 → 343
    7tmA_BK-2; bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001379692.1 → NP_001366621.1  B2 bradykinin receptor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL355102
    Consensus CDS
    CCDS9942.1
    UniProtKB/Swiss-Prot
    P30411
    UniProtKB/TrEMBL
    B4DRL4, Q68DM8
    Related
    ENSP00000450482.1, ENST00000554311.2
    Conserved Domains (1) summary
    cd15381
    Location:58 → 343
    7tmA_BK-2; bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    96204839..96244164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    90436088..90475413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30411.2 GenPept UniProtKB/Swiss-Prot:P30411

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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