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Ifi213 interferon activated gene 213 [ Mus musculus (house mouse) ]

Gene ID: 623121, updated on 11-Apr-2024

Summary

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Official Symbol
Ifi213provided by MGI
Official Full Name
interferon activated gene 213provided by MGI
Primary source
MGI:MGI:3695276
See related
Ensembl:ENSMUSG00000073491 AllianceGenome:MGI:3695276
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pydc4; Pyr-A; E030037K03Rik; E430029J22Rik
Summary
Predicted to enable double-stranded DNA binding activity. Predicted to be involved in cellular response to interferon-beta. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 4.0), mammary gland adult (RPKM 3.5) and 9 other tissues See more
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Genomic context

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Location:
1 H3; 1 80.49 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (173393849..173426868, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (173566280..173599348, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03079 Neighboring gene interferon activated gene 206 Neighboring gene STARR-seq mESC enhancer starr_03080 Neighboring gene STARR-positive B cell enhancer ABC_E10059 Neighboring gene STARR-positive B cell enhancer ABC_E4392 Neighboring gene interferon activated gene 214 Neighboring gene STARR-positive B cell enhancer ABC_E11699 Neighboring gene STARR-seq mESC enhancer starr_03081 Neighboring gene STARR-positive B cell enhancer ABC_E10060 Neighboring gene STARR-positive B cell enhancer ABC_E5857 Neighboring gene STARR-positive B cell enhancer ABC_E4393 Neighboring gene interferon activated gene 209 Neighboring gene STARR-positive B cell enhancer mm9_chr1:175599072-175599372 Neighboring gene STARR-seq mESC enhancer starr_03083 Neighboring gene interferon activated gene 208

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The mammalian PYHIN gene family: phylogeny, evolution and expression. Cridland JA, et al. BMC Evol Biol, 2012 Aug 7. PMID 22871040, Free PMC Article
  2. Extensive evolutionary and functional diversity among mammalian AIM2-like receptors. Brunette RL, et al. J Exp Med, 2012 Oct 22. PMID 23045604, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to interferon-beta IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
interferon activated gene 213
Names
pyrin domain containing 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177349.2 → NP_001170820.1  interferon activated gene 213 isoform a

    See identical proteins and their annotated locations for NP_001170820.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variant 2, encodes isoform a.
    Source sequence(s)
    AC117682
    Consensus CDS
    CCDS48450.1
    UniProtKB/TrEMBL
    Q3UPZ5
    Related
    ENSMUSP00000095070.3, ENSMUST00000097462.9
    Conserved Domains (1) summary
    cd08305
    Location:14 → 84
    Pyrin; Pyrin: a protein-protein interaction domain

  2. NM_001177350.2 → NP_001170821.1  interferon activated gene 213 isoform a

    See identical proteins and their annotated locations for NP_001170821.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variant 1, encodes isoform a.
    Source sequence(s)
    AC117682
    Consensus CDS
    CCDS48450.1
    UniProtKB/TrEMBL
    Q3UPZ5
    Related
    ENSMUSP00000136238.2, ENSMUST00000180215.2
    Conserved Domains (1) summary
    cd08305
    Location:14 → 84
    Pyrin; Pyrin: a protein-protein interaction domain

  3. NM_001368798.1 → NP_001355727.1  interferon activated gene 213 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (b).
    Source sequence(s)
    AC117682
    Conserved Domains (2) summary
    COG5422
    Location:156 → 449
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    cd08305
    Location:14 → 84
    Pyrin; a protein-protein interaction domain

  4. NM_001368799.1 → NP_001355728.1  interferon activated gene 213 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC117682
    Conserved Domains (2) summary
    COG5422
    Location:156 → 449
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    cd08305
    Location:14 → 84
    Pyrin; a protein-protein interaction domain

RNA

  1. NR_160907.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117682

  2. NR_160908.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117682

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    173393849..173426868 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238852.3 → XP_011237154.1  interferon activated gene 213 isoform X3

    UniProtKB/TrEMBL
    D3Z5G0
    Related
    ENSMUSP00000117222.2, ENSMUST00000150649.9
    Conserved Domains (2) summary
    COG5422
    Location:156 → 449
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    cd08305
    Location:14 → 84
    Pyrin; a protein-protein interaction domain

  2. XM_011238851.3 → XP_011237153.1  interferon activated gene 213 isoform X2

    Conserved Domains (2) summary
    COG5422
    Location:156 → 449
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    cd08305
    Location:14 → 84
    Pyrin; a protein-protein interaction domain

  3. XM_011238850.4 → XP_011237152.1  interferon activated gene 213 isoform X1

    Conserved Domains (3) summary
    COG5422
    Location:156 → 449
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    cd08305
    Location:14 → 84
    Pyrin; a protein-protein interaction domain
    pfam15695
    Location:505 → 569
    HERV-K_REC; Rec (regulator of expression encoded by corf) of HERV-K-113

  4. XM_036152616.1 → XP_036008509.1  interferon activated gene 213 isoform X5

    Conserved Domains (1) summary
    COG5422
    Location:16 → 309
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]

  5. XM_030255718.2 → XP_030111578.1  interferon activated gene 213 isoform X4

    Conserved Domains (2) summary
    COG5422
    Location:156 → 449
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    cd08305
    Location:14 → 84
    Pyrin; a protein-protein interaction domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033384.1: Suppressed sequence

    Description
    NM_001033384.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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