Mcidas multiciliate differentiation and DNA synthesis associated cell cycle protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mcidasprovided by MGI
Official Full Name: multiciliate differentiation and DNA synthesis associated cell cycle proteinprovided by MGI
Primary source: MGI:MGI:3648807
See related: Ensembl:ENSMUSG00000074651 AllianceGenome:MGI:3648807
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mci; Idas; Mcin; Gm6320; EG622408
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including motile cilium assembly; negative regulation of DNA replication; and regulation of cilium assembly. Predicted to act upstream of or within cell projection organization. Predicted to be located in nuclear body. Predicted to be active in nucleus. Is expressed in brain; female reproductive system; liver; and respiratory system. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 42. Orthologous to human MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 13 D2.2; 13 63.93 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (113130104..113138233)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (112993581..113000394)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show defects in efferent duct multiciliogenesis underlie male infertility in GEMC1-, MCIDAS- or CCNO-deficient mice
Title: Defects in efferent duct multiciliogenesis underlie male infertility in GEMC1-, MCIDAS- or CCNO-deficient mice.
GMNC protein induces Mci expression that drives the second step of basal body production for multiciliation
Title: Mcidas mutant mice reveal a two-step process for the specification and differentiation of multiciliated cells in mammals.
Results suggest that Mcidas and GemC1 are key players in the generation of multiciliated ependymal cells of the adult neurogenic niche.
Title: Mcidas and GemC1 are key regulators for the generation of multiciliated ependymal cells in the adult neurogenic niche.
Idas as a novel Geminin binding partner, implicated in cell cycle progression, and a putative regulator of proliferation-differentiation decisions during development.
Title: Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables transcription regulator activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in motile cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of DNA replication	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated DNA replication initiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nuclear body	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: multicilin

Names: multiciliate cell differentiation; protein Idas

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.