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Triml2 tripartite motif family-like 2 [ Mus musculus (house mouse) ]

Gene ID: 622117, updated on 5-Mar-2024

Summary

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Official Symbol
Triml2provided by MGI
Official Full Name
tripartite motif family-like 2provided by MGI
Primary source
MGI:MGI:3642989
See related
Ensembl:ENSMUSG00000091490 AllianceGenome:MGI:3642989
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tu4; EG622117
Summary
Predicted to enable protein homodimerization activity; protein kinase binding activity; and ubiquitin protein ligase activity. Acts upstream of or within response to retinoic acid. Predicted to be active in cytosol and nucleoplasm. Orthologous to human TRIML2 (tripartite motif family like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward placenta adult (RPKM 4.9) See more
Orthologs
human all
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Genomic context

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Location:
8 A4; 8 23.89 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (43633500..43646921)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (43180463..43193884)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene tryptophanyl-tRNA synthetase pseudogene Neighboring gene STARR-seq mESC enhancer starr_21309 Neighboring gene STARR-seq mESC enhancer starr_21310 Neighboring gene tripartite motif family-like 1 Neighboring gene STARR-seq mESC enhancer starr_21312 Neighboring gene STARR-seq mESC enhancer starr_21313 Neighboring gene STARR-seq mESC enhancer starr_21314 Neighboring gene bromodomain adjacent to zinc finger domain, 2A pseudogene Neighboring gene STARR-seq mESC enhancer starr_21316 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_21317 Neighboring gene STARR-seq mESC enhancer starr_21318 Neighboring gene STARR-seq mESC enhancer starr_21319 Neighboring gene STARR-seq mESC enhancer starr_21325 Neighboring gene zinc finger protein 42

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes. Ringel AR, et al. Cell, 2022 Sep 29. PMID 36179666, Free PMC Article
  2. Identification of TRIML2, a novel p53 target, that enhances p53 SUMOylation and regulates the transactivation of proapoptotic genes. Kung CP, et al. Mol Cancer Res, 2015 Feb. PMID 25256710, Free PMC Article
  3. Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency. Kunarso G, et al. BMC Genomics, 2008 Apr 9. PMID 18400104, Free PMC Article
  4. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that TRIML2 is part of a feed-forward loop that activates p53 in cells expressing the R72 variant, particularly after prolonged stress.
    Title: Identification of TRIML2, a novel p53 target, that enhances p53 SUMOylation and regulates the transactivation of proapoptotic genes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to organic substance IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to retinoic acid IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable E3 ubiquitin-protein ligase TRIML2
NP_001153884.1
NP_001368858.1
XP_006509536.1
XP_017168415.1
XP_030099563.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160412.2 → NP_001153884.1  probable E3 ubiquitin-protein ligase TRIML2

    See identical proteins and their annotated locations for NP_001153884.1

    Status: VALIDATED

    Source sequence(s)
    AC142104
    Consensus CDS
    CCDS52546.1
    UniProtKB/TrEMBL
    B2M0R4, E9PW10
    Related
    ENSMUSP00000148196.2, ENSMUST00000210136.2
    Conserved Domains (3) summary
    COG1196
    Location:55 → 243
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13733
    Location:245 → 418
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
    cl00034
    Location:18 → 58
    Bbox_SF; B-box-type zinc finger superfamily

  2. NM_001381929.1 → NP_001368858.1  probable E3 ubiquitin-protein ligase TRIML2

    Status: VALIDATED

    Source sequence(s)
    AC142104
    UniProtKB/TrEMBL
    B2M0R4, E9PW10
    Related
    ENSMUSP00000147371.2, ENSMUST00000209200.2
    Conserved Domains (3) summary
    COG1196
    Location:55 → 243
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13733
    Location:245 → 418
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
    cl00034
    Location:18 → 58
    Bbox_SF; B-box-type zinc finger superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    43633500..43646921
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312926.3 → XP_017168415.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X1

    UniProtKB/TrEMBL
    B2M0R4, E9PW10
    Conserved Domains (3) summary
    COG1196
    Location:55 → 243
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13733
    Location:245 → 418
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
    cl00034
    Location:18 → 58
    Bbox_SF; B-box-type zinc finger superfamily

  2. XM_030243703.1 → XP_030099563.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X3

    Conserved Domains (1) summary
    cl00034
    Location:18 → 58
    Bbox_SF; B-box-type zinc finger superfamily

  3. XM_006509473.2 → XP_006509536.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X2

    UniProtKB/TrEMBL
    B2M0R5
    Conserved Domains (1) summary
    cd13733
    Location:143 → 316
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

RNA

  1. XR_001778460.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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