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RPS15A ribosomal protein S15a [ Homo sapiens (human) ]

Gene ID: 6210, updated on 7-Apr-2024

Summary

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Official Symbol
RPS15Aprovided by HGNC
Official Full Name
ribosomal protein S15aprovided by HGNC
Primary source
HGNC:HGNC:10389
See related
Ensembl:ENSG00000134419 MIM:603674; AllianceGenome:HGNC:10389
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
uS8; S15a; DBA20
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 1052.3), bone marrow (RPKM 811.7) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
16p12.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (18781295..18790334, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (18717732..18726769, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (18792617..18801656, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10538 Neighboring gene ATP binding cassette subfamily C member 6 pseudogene 1 Neighboring gene uncharacterized LOC124903655 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:18800609-18801326 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10519 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10521 Neighboring gene ADP ribosylation factor like GTPase 6 interacting protein 1 Neighboring gene SMG1 nonsense mediated mRNA decay associated PI3K related kinase Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Ribosomal protein RPS15A augments proliferation of colorectal cancer RKO cells via regulation of BIRC3, p38 MAPK and Chk1. Wan BS, et al. Eur Rev Med Pharmacol Sci, 2021 Jun. PMID 34156695
  2. Ribosomal protein small subunit 15A (RPS15A) inhibits the apoptosis of breast cancer MDA-MB-231 cells via upregulating phosphorylated ERK1/2, Bad, and Chk1. Kong L, et al. J Cell Biochem, 2020 Jan. PMID 31535410
  3. RPS15A promotes gastric cancer progression via activation of the Akt/IKK-β/NF-κB signalling pathway. Liu C, et al. J Cell Mol Med, 2019 Mar. PMID 30661291, Free PMC Article
  4. Knockdown of ribosomal protein S15A inhibits human kidney cancer cell growth in vitro and in vivo. Liang J, et al. Mol Med Rep, 2019 Feb. PMID 30569143, Free PMC Article
  5. RPS15a Silencing Suppresses Cell Proliferation and Migration of Gastric Cancer. Shi D, et al. Yonsei Med J, 2018 Dec. PMID 30450850, Free PMC Article

See all (204) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MicroRNA-147b induces neuroendocrine differentiation of prostate cancer cells by targeting ribosomal protein RPS15A.
    Title: MicroRNA-147b induces neuroendocrine differentiation of prostate cancer cells by targeting ribosomal protein RPS15A.
  2. FOXN3 inhibits the progression of ovarian cancer through negatively regulating the expression of RPS15A.
    Title: FOXN3 inhibits the progression of ovarian cancer through negatively regulating the expression of RPS15A.
  3. Ribosomal protein RPS15A augments proliferation of colorectal cancer RKO cells via regulation of BIRC3, p38 MAPK and Chk1.
    Title: Ribosomal protein RPS15A augments proliferation of colorectal cancer RKO cells via regulation of BIRC3, p38 MAPK and Chk1.
  4. MicroRNA-147b suppresses the proliferation and invasion of non-small-cell lung cancer cells through downregulation of Wnt/beta-catenin signalling via targeting of RPS15A.
    Title: MicroRNA-147b suppresses the proliferation and invasion of non-small-cell lung cancer cells through downregulation of Wnt/β-catenin signalling via targeting of RPS15A.
  5. Ribosomal protein small subunit 15A (RPS15A) inhibits the apoptosis of breast cancer MDA-MB-231 cells via upregulating phosphorylated ERK1/2, Bad, and Chk1.
    Title: Ribosomal protein small subunit 15A (RPS15A) inhibits the apoptosis of breast cancer MDA-MB-231 cells via upregulating phosphorylated ERK1/2, Bad, and Chk1.
  6. Ribosomal protein S15a (RPS15A) is up-regulated in gastric cancer (GC) patients and associated with poor prognosis.
    Title: RPS15A promotes gastric cancer progression via activation of the Akt/IKK-β/NF-κB signalling pathway.
  7. miR-29a-3p inhibits CRC cell function possibly by targeting RPS15A
    Title: Downregulation of RPS15A by miR-29a-3p attenuates cell proliferation in colorectal carcinoma.
  8. A preliminary experimental basis for RPS15A as a novel oncogene and potential therapeutic target in RCC.
    Title: Knockdown of ribosomal protein S15A inhibits human kidney cancer cell growth in vitro and in vivo.
  9. The present study found RPS15a expression to be higher in gastric tumors and its silencing in gastric cancer cells to inhibit the proliferation, growth, and migration thereof. Accordingly, RPS15a may be considered as a potential therapeutic target in gastric cancer.
    Title: RPS15a Silencing Suppresses Cell Proliferation and Migration of Gastric Cancer.
  10. High RPS15A expression is associated with angiogenesis in hepatocellular carcinoma.
    Title: Ribosomal protein S15a promotes tumor angiogenesis via enhancing Wnt/β-catenin-induced FGF18 expression in hepatocellular carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Diamond-Blackfan anemia 20
MedGen: C5193022 OMIM: 618313 GeneReviews: Diamond-Blackfan Anemia
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ27457, MGC111208

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome HDA PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ribosomal small subunit biogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translation IC
Inferred by Curator
more info
 PubMed 
involved_in translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit HDA PubMed 
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in membrane HDA PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
part_of small-subunit processome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
small ribosomal subunit protein uS8
Names
40S ribosomal protein S15a
up-regulated by HBV X protein
NP_001010.2
NP_001025180.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001019.5 → NP_001010.2  small ribosomal subunit protein uS8

    See identical proteins and their annotated locations for NP_001010.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is the longest transcript and utilizes an alternate splice site on the 5'-terminal exon, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC138811, BC001697, BF678907
    Consensus CDS
    CCDS10571.1
    UniProtKB/Swiss-Prot
    P39027, P39031, P62244, Q3MHD9, Q8C023, Q9BV24
    UniProtKB/TrEMBL
    A8K7H3, B2R4W8
    Related
    ENSP00000318646.4, ENST00000322989.8
    Conserved Domains (1) summary
    PTZ00158
    Location:1 → 130
    PTZ00158; 40S ribosomal protein S15A; Provisional

  2. NM_001030009.2 → NP_001025180.1  small ribosomal subunit protein uS8

    See identical proteins and their annotated locations for NP_001025180.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the predominant transcript and utilizes an alternate splice site on the 5'-terminal exon, compared to variant 2. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC138811, AK130967, BC030569
    Consensus CDS
    CCDS10571.1
    UniProtKB/Swiss-Prot
    P39027, P39031, P62244, Q3MHD9, Q8C023, Q9BV24
    UniProtKB/TrEMBL
    A8K7H3, B2R4W8
    Related
    ENSP00000457000.1, ENST00000563390.5
    Conserved Domains (1) summary
    PTZ00158
    Location:1 → 130
    PTZ00158; 40S ribosomal protein S15A; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    18781295..18790334 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    18717732..18726769 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62244.2 GenPept UniProtKB/Swiss-Prot:P62244

Gene LinkOut

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