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Gm12185 predicted gene 12185 [ Mus musculus (house mouse) ]

Gene ID: 620913, updated on 11-Apr-2024

Summary

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Official Symbol
Gm12185provided by MGI
Official Full Name
predicted gene 12185provided by MGI
Primary source
MGI:MGI:3652173
See related
Ensembl:ENSMUSG00000048852 AllianceGenome:MGI:3652173
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Irgb2b1
Summary
Predicted to enable GTPase activity. Predicted to be involved in cellular response to interferon-beta and defense response. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
11 B1.2; 11 28.89 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (48795483..48818009, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (48904656..48927182, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9362 Neighboring gene STARR-positive B cell enhancer ABC_E8397 Neighboring gene immunity-related GTPase family M member 1 Neighboring gene predicted gene 5431 Neighboring gene STARR-positive B cell enhancer ABC_E6975 Neighboring gene RIKEN cDNA 9930111J21 gene 1 Neighboring gene protease (prosome, macropain) activator subunit 2B Neighboring gene STARR-positive B cell enhancer mm9_chr11:48793591-48793892 Neighboring gene predicted gene, 42074 Neighboring gene STARR-seq mESC enhancer starr_29366 Neighboring gene T cell specific GTPase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice. Murillo-León M, et al. Nat Commun, 2019 Mar 15. PMID 30874554, Free PMC Article
  2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
  5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC6071

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to interferon-beta IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interferon inducible GTPase
Names
Immunity related GTPase, B2-B1 tandem, WSB specific

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045540.2 → NP_001039005.1  interferon inducible GTPase

    See identical proteins and their annotated locations for NP_001039005.1

    Status: VALIDATED

    Source sequence(s)
    AL645849
    Consensus CDS
    CCDS36142.1
    UniProtKB/TrEMBL
    A0A1G5SJB0, Q5NCB2
    Related
    ENSMUSP00000092049.3, ENSMUST00000094476.9
    Conserved Domains (3) summary
    cd04104
    Location:472 → 668
    p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
    pfam05049
    Location:438 → 810
    IIGP; Interferon-inducible GTPase (IIGP)
    cl21455
    Location:61 → 257
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    48795483..48818009 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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