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RPS9 ribosomal protein S9 [ Homo sapiens (human) ]

Gene ID: 6203, updated on 7-Apr-2024

Summary

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Official Symbol
RPS9provided by HGNC
Official Full Name
ribosomal protein S9provided by HGNC
Primary source
HGNC:HGNC:10442
See related
Ensembl:ENSG00000170889 MIM:603631; AllianceGenome:HGNC:10442
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S9; uS4
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S4P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 603.9), bone marrow (RPKM 379.2) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
19q13.42
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (54200858..54207647)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (57281246..57288035)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54704726..54711515)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene transmembrane channel like 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54676977-54677793 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54677794-54678609 Neighboring gene membrane bound O-acyltransferase domain containing 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54683683-54684198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54684199-54684714 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54684715-54685229 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54687509-54688008 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54692762-54693444 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54693445-54694126 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:54695049-54695250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54696095-54696610 Neighboring gene tRNA splicing endonuclease subunit 34 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54704113-54704783 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54709694-54710202 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54710710-54711217 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54711218-54711724 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:54711820-54712003 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:54712450-54712625 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54720754-54721590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54721591-54722426 Neighboring gene uncharacterized LOC124904768 Neighboring gene leukocyte immunoglobulin like receptor B3 Neighboring gene uncharacterized LOC107985279 Neighboring gene LSM14A, SCD6 homolog A (S. cerevisiae) pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [Ribosomal Protein S9 Expression in Multiple Myeloma and Its Effect on Cell Biological Function]. Song KP, et al. Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 2019 Apr 28. PMID 31060671
  2. Identification of genes responsive to BPDE treatment in HeLa cells using cDNA expression assays. Yu Z, et al. Environ Mol Mutagen, 2000. PMID 11044901
  3. LncRNA BRCAT54 inhibits the tumorigenesis of non-small cell lung cancer by binding to RPS9 to transcriptionally regulate JAK-STAT and calcium pathway genes. Yang W, et al. Carcinogenesis, 2021 Feb 11. PMID 32459848
  4. Elucidation of motifs in ribosomal protein S9 that mediate its nucleolar localization and binding to NPM1/nucleophosmin. Lindström MS. PLoS One, 2012. PMID 23285058, Free PMC Article
  5. Silencing of ribosomal protein S9 elicits a multitude of cellular responses inhibiting the growth of cancer cells subsequent to p53 activation. Lindström MS, et al. PLoS One, 2010 Mar 8. PMID 20221446, Free PMC Article

See all (216) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LAPTM4B promotes AML progression through regulating RPS9/STAT3 axis.
    Title: LAPTM4B promotes AML progression through regulating RPS9/STAT3 axis.
  2. LncRNA BRCAT54 inhibits the tumorigenesis of non-small cell lung cancer by binding to RPS9 to transcriptionally regulate JAK-STAT and calcium pathway genes.
    Title: LncRNA BRCAT54 inhibits the tumorigenesis of non-small cell lung cancer by binding to RPS9 to transcriptionally regulate JAK-STAT and calcium pathway genes.
  3. Inhibition of RPS9 can promote apoptosis, cell cycle arrest, and proliferation of myeloma cells. RPS9 can affect the activation of NF-kappaB pathway and cell apoptosis through SENP1
    Title: [Ribosomal Protein S9 Expression in Multiple Myeloma and Its Effect on Cell Biological Function].
  4. RPS9/LILRB3 (rs11666543) was associated with Takayasu arteritis.
    Title: Identification of Susceptibility Loci in IL6, RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome-Wide Association Study.
  5. Evaluating different RPS9 fragments for their ability to bind NPM1 indicated that there are two binding sites for NPM1 on RPS9.
    Title: Elucidation of motifs in ribosomal protein S9 that mediate its nucleolar localization and binding to NPM1/nucleophosmin.
  6. ribosomal protein S9 silencing elicits a multitude of cellular responses inhibiting the growth of cancer cells subsequent to p53 activation
    Title: Silencing of ribosomal protein S9 elicits a multitude of cellular responses inhibiting the growth of cancer cells subsequent to p53 activation.
  7. Observational study of gene-disease association. (HuGE Navigator)
    Title: Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.
  8. B23 selectively stores, and protects ribosomal protein S9 in nucleoli and therefore could facilitate ribosome biogenesis.
    Title: Ribosomal protein S9 is a novel B23/NPM-binding protein required for normal cell proliferation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribosomal protein S9 (RPS9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribosomal protein S9 (RPS9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify ribosomal protein S9 (RPS9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ribosomal protein S9 (RPS9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome HDA PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal small subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal small subunit biogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translation IC
Inferred by Curator
more info
 PubMed 
involved_in translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit HDA PubMed 
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in focal adhesion HDA PubMed 
located_in membrane HDA PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus HDA PubMed 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
part_of small-subunit processome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
small ribosomal subunit protein uS4
Names
40S ribosomal protein S9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013.4 → NP_001004.2  small ribosomal subunit protein uS4 isoform a

    See identical proteins and their annotated locations for NP_001004.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), as well as variants 2, 3, and 4, encodes isoform a.
    Source sequence(s)
    AB055775, BC007410, U14971
    Consensus CDS
    CCDS12884.1
    UniProtKB/Swiss-Prot
    A9C4C1, P46781, Q4QRK7, Q9BVZ0
    Related
    ENSP00000302896.4, ENST00000302907.9
    Conserved Domains (1) summary
    PTZ00155
    Location:11 → 177
    PTZ00155; 40S ribosomal protein S9; Provisional

  2. NM_001321701.2 → NP_001308630.1  small ribosomal subunit protein uS4 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variants 1, 3, and 4, encodes isoform a.
    Source sequence(s)
    BC050660, CD389050
    Consensus CDS
    CCDS12884.1
    UniProtKB/Swiss-Prot
    A9C4C1, P46781, Q4QRK7, Q9BVZ0
    Conserved Domains (1) summary
    PTZ00155
    Location:11 → 177
    PTZ00155; 40S ribosomal protein S9; Provisional

  3. NM_001321702.2 → NP_001308631.1  small ribosomal subunit protein uS4 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 1, 2, and 4, encodes isoform a.
    Source sequence(s)
    AC245052, BC050660, BM313608, CD389050
    Consensus CDS
    CCDS12884.1
    UniProtKB/Swiss-Prot
    A9C4C1, P46781, Q4QRK7, Q9BVZ0
    Related
    ENSP00000375632.1, ENST00000391752.5
    Conserved Domains (1) summary
    PTZ00155
    Location:11 → 177
    PTZ00155; 40S ribosomal protein S9; Provisional

  4. NM_001321704.2 → NP_001308633.1  small ribosomal subunit protein uS4 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 1, 2, and 3, encodes isoform a.
    Source sequence(s)
    BC050660, BQ069656, CD389050
    Consensus CDS
    CCDS12884.1
    UniProtKB/Swiss-Prot
    A9C4C1, P46781, Q4QRK7, Q9BVZ0
    Conserved Domains (1) summary
    PTZ00155
    Location:11 → 177
    PTZ00155; 40S ribosomal protein S9; Provisional

  5. NM_001321705.2 → NP_001308634.1  small ribosomal subunit protein uS4 isoform b

    Status: REVIEWED

    Source sequence(s)
    AW163829, BC050660, CD389050
    Conserved Domains (1) summary
    PTZ00155
    Location:11 → 136
    PTZ00155; 40S ribosomal protein S9; Provisional

  6. NM_001321706.2 → NP_001308635.1  small ribosomal subunit protein uS4 isoform c

    Status: REVIEWED

    Source sequence(s)
    BC050660, CD389050
    Consensus CDS
    CCDS82397.1
    UniProtKB/TrEMBL
    A8MXK4, F2Z3C0
    Related
    ENSP00000375631.3, ENST00000391751.7
    Conserved Domains (1) summary
    PTZ00155
    Location:11 → 76
    PTZ00155; 40S ribosomal protein S9; Provisional

RNA

  1. NR_135762.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    BC050660, BG911482, CD389050
    Related
    ENST00000436445.5

  2. NR_135763.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    BC050660, BG753945, CD389050

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    54200858..54207647
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027112.2 → XP_016882601.1  small ribosomal subunit protein uS4 isoform X1

    UniProtKB/TrEMBL
    A8MXK4, F2Z3C0
    Conserved Domains (1) summary
    PTZ00155
    Location:11 → 76
    PTZ00155; 40S ribosomal protein S9; Provisional

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003571054.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    175657..182446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NW_003571055.2 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    175840..182629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330201.1 → XP_054186176.1  small ribosomal subunit protein uS4 isoform X1

    UniProtKB/TrEMBL
    A8MXK4

  2. XM_054330200.1 → XP_054186175.1  small ribosomal subunit protein uS4 isoform X1

    UniProtKB/TrEMBL
    A8MXK4

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NW_003571056.2 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    175840..182629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330497.1 → XP_054186472.1  small ribosomal subunit protein uS4 isoform X1

    UniProtKB/TrEMBL
    A8MXK4

Reference GRCh38.p14 ALT_REF_LOCI_4

Genomic

  1. NW_003571057.2 Reference GRCh38.p14 ALT_REF_LOCI_4

    Range
    175840..182629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330747.1 → XP_054186722.1  small ribosomal subunit protein uS4 isoform X1

    UniProtKB/TrEMBL
    A8MXK4

  2. XM_054330746.1 → XP_054186721.1  small ribosomal subunit protein uS4 isoform X1

    UniProtKB/TrEMBL
    A8MXK4

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

  1. NW_003571058.2 Reference GRCh38.p14 ALT_REF_LOCI_5

    Range
    175840..182629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330978.1 → XP_054186953.1  small ribosomal subunit protein uS4 isoform X1

    UniProtKB/TrEMBL
    A8MXK4

  2. XM_054330977.1 → XP_054186952.1  small ribosomal subunit protein uS4 isoform X1

    UniProtKB/TrEMBL
    A8MXK4

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NW_003571059.2 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    175840..182629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331261.1 → XP_054187236.1  small ribosomal subunit protein uS4 isoform X1

    UniProtKB/TrEMBL
    A8MXK4

  2. XM_054331260.1 → XP_054187235.1  small ribosomal subunit protein uS4 isoform X1

    UniProtKB/TrEMBL
    A8MXK4

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

  1. NW_003571060.1 Reference GRCh38.p14 ALT_REF_LOCI_7

    Range
    175830..182618
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331530.1 → XP_054187505.1  small ribosomal subunit protein uS4 isoform X1

    UniProtKB/TrEMBL
    A8MXK4

Reference GRCh38.p14 ALT_REF_LOCI_8

Genomic

  1. NW_003571061.2 Reference GRCh38.p14 ALT_REF_LOCI_8

    Range
    175840..182629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333575.1 → XP_054189550.1  small ribosomal subunit protein uS4 isoform X1

    UniProtKB/TrEMBL
    A8MXK4

  2. XM_054333574.1 → XP_054189549.1  small ribosomal subunit protein uS4 isoform X1

    UniProtKB/TrEMBL
    A8MXK4

Reference GRCh38.p14 ALT_REF_LOCI_9

Genomic

  1. NT_187693.1 Reference GRCh38.p14 ALT_REF_LOCI_9

    Range
    175840..182629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333677.1 → XP_054189652.1  small ribosomal subunit protein uS4 isoform X1

    UniProtKB/TrEMBL
    A8MXK4

  2. XM_054333676.1 → XP_054189651.1  small ribosomal subunit protein uS4 isoform X1

    UniProtKB/TrEMBL
    A8MXK4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    57281246..57288035
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321702.1 → XP_054177677.1  small ribosomal subunit protein uS4 isoform X1

    UniProtKB/TrEMBL
    A8MXK4

  2. XM_054321701.1 → XP_054177676.1  small ribosomal subunit protein uS4 isoform X1

    UniProtKB/TrEMBL
    A8MXK4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46781.3 GenPept UniProtKB/Swiss-Prot:P46781

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