U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Klf14 Kruppel-like transcription factor 14 [ Mus musculus (house mouse) ]

Gene ID: 619665, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Klf14provided by MGI
Official Full Name
Kruppel-like transcription factor 14provided by MGI
Primary source
MGI:MGI:3577024
See related
Ensembl:ENSMUSG00000073209 AllianceGenome:MGI:3577024
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BTEB5; 5330411L03Rik
Summary
Enables chromatin binding activity. Acts upstream of or within positive regulation of sphingolipid mediated signaling pathway and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including brain; gut; male reproductive gland or organ; respiratory system; and skin. Orthologous to human KLF14 (Kruppel like factor 14). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
6 A3.3; 6 12.54 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (30932956..30935925, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (30956021..30958990, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene coatomer protein complex, subunit gamma 2 Neighboring gene RIKEN cDNA 4930412F09 gene Neighboring gene predicted gene, 38781 Neighboring gene testis specific gene A13 Neighboring gene STARR-seq mESC enhancer starr_15475 Neighboring gene predicted gene, 40359 Neighboring gene microRNA 29a

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Hepatic Krüppel-like factor 14 regulates lipid metabolism in nonalcoholic steatohepatitis mice. Chen X, et al. FASEB J, 2023 Aug. PMID 37389939
  2. The transcription factor KLF14 attenuates LPS-induced acute lung injury by ameliorating apoptosis of alveolar epithelial cells in mice. Liu L, et al. Mol Immunol, 2022 Dec. PMID 36279660
  3. Adipocyte-Specific Modulation of KLF14 Expression in Mice Leads to Sex-Dependent Impacts on Adiposity and Lipid Metabolism. Yang Q, et al. Diabetes, 2022 Apr 1. PMID 35081256, Free PMC Article
  4. A novel role for the Krüppel-like factor 14 on macrophage inflammatory response and atherosclerosis development. Wei X, et al. Cardiovasc Pathol, 2017 Mar-Apr. PMID 27923151
  5. Upregulation of KLF14 expression attenuates kidney fibrosis by inducing PPARα-mediated fatty acid oxidation. Chen L, et al. Free Radic Biol Med, 2023 Feb 1. PMID 36584797

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kruppel-like factor 14 ameliorated obesity and related metabolic disorders by promoting adipose tissue browning.
    Title: Kruppel-like factor 14 ameliorated obesity and related metabolic disorders by promoting adipose tissue browning.
  2. Downregulation of Kruppel-like factor 14 accelerated cellular senescence and aging.
    Title: Downregulation of Krüppel-like factor 14 accelerated cellular senescence and aging.
  3. Hepatic Kruppel-like factor 14 regulates lipid metabolism in nonalcoholic steatohepatitis mice.
    Title: Hepatic Krüppel-like factor 14 regulates lipid metabolism in nonalcoholic steatohepatitis mice.
  4. Upregulation of KLF14 expression attenuates kidney fibrosis by inducing PPARalpha-mediated fatty acid oxidation.
    Title: Upregulation of KLF14 expression attenuates kidney fibrosis by inducing PPARα-mediated fatty acid oxidation.
  5. The transcription factor KLF14 attenuates LPS-induced acute lung injury by ameliorating apoptosis of alveolar epithelial cells in mice.
    Title: The transcription factor KLF14 attenuates LPS-induced acute lung injury by ameliorating apoptosis of alveolar epithelial cells in mice.
  6. The transcription factor KLF14 regulates macrophage glycolysis and immune function by inhibiting HK2 in sepsis.
    Title: The transcription factor KLF14 regulates macrophage glycolysis and immune function by inhibiting HK2 in sepsis.
  7. Adipocyte-Specific Modulation of KLF14 Expression in Mice Leads to Sex-Dependent Impacts on Adiposity and Lipid Metabolism.
    Title: Adipocyte-Specific Modulation of KLF14 Expression in Mice Leads to Sex-Dependent Impacts on Adiposity and Lipid Metabolism.
  8. Kruppel-like factor 14 deletion in myeloid cells accelerates atherosclerotic lesion development.
    Title: Krüppel-like factor 14 deletion in myeloid cells accelerates atherosclerotic lesion development.
  9. Klf14 is an imprinted transcription factor that regulates placental growth.
    Title: Klf14 is an imprinted transcription factor that regulates placental growth.
  10. Kruppel-like factor 14 inhibits atherosclerosis via mir-27a-mediated down-regulation of lipoprotein lipase expression in vivo.
    Title: Krüppel-like factor 14 inhibits atherosclerosis via mir-27a-mediated down-regulation of lipoprotein lipase expression in vivo.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription factor binding IC
Inferred by Curator
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of sphingolipid mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Krueppel-like factor 14
Names
Kruppel-like factor 14

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135093.1 → NP_001128565.1  Krueppel-like factor 14

    See identical proteins and their annotated locations for NP_001128565.1

    Status: VALIDATED

    Source sequence(s)
    AC121800
    Consensus CDS
    CCDS51744.1
    UniProtKB/Swiss-Prot
    Q19A41
    Related
    ENSMUSP00000099122.4, ENSMUST00000101589.5
    Conserved Domains (3) summary
    COG5048
    Location:198 → 283
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:200 → 219
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:241 → 266
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    30932956..30935925 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q19A41.1 GenPept UniProtKB/Swiss-Prot:Q19A41

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous