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RPS6KA1 ribosomal protein S6 kinase A1 [ Homo sapiens (human) ]

Gene ID: 6195, updated on 3-Apr-2024

Summary

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Official Symbol
RPS6KA1provided by HGNC
Official Full Name
ribosomal protein S6 kinase A1provided by HGNC
Primary source
HGNC:HGNC:10430
See related
Ensembl:ENSG00000117676 MIM:601684; AllianceGenome:HGNC:10430
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RSK; HU-1; RSK1; p90Rsk; MAPKAPK1; MAPKAPK1A
Summary
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Expression
Broad expression in small intestine (RPKM 31.6), duodenum (RPKM 29.3) and 21 other tissues See more
Orthologs
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Genomic context

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See RPS6KA1 in Genome Data Viewer
Location:
1p36.11
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (26529761..26575025)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (26367713..26412979)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26856252..26901516)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26798247-26798956 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 478 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 479 Neighboring gene MPRA-validated peak134 silencer Neighboring gene high mobility group nucleosomal binding domain 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 481 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:26827864-26828521 Neighboring gene CRISPRi-validated cis-regulatory element chr1.3789 Neighboring gene developmental pluripotency associated 2 pseudogene 2 Neighboring gene uncharacterized LOC124903884 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 482 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26856858-26857768 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26857769-26858680 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 507 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 483 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26868826-26869470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 509 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 484 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 510 Neighboring gene microRNA 1976 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 511 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 512 Neighboring gene RNA, 7SL, cytoplasmic 679, pseudogene Neighboring gene U7 small nuclear RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Aberrant expression of RSK1 characterizes high-grade gliomas with immune infiltration. M Hajj GN, et al. Mol Oncol, 2020 Jan. PMID 31701625, Free PMC Article
  2. Dynamic control of RSK complexes by phosphoswitch-based regulation. Gógl G, et al. FEBS J, 2018 Jan. PMID 29083550
  3. RSK1 protects P-glycoprotein/ABCB1 against ubiquitin-proteasomal degradation by downregulating the ubiquitin-conjugating enzyme E2 R1. Katayama K, et al. Sci Rep, 2016 Oct 27. PMID 27786305, Free PMC Article
  4. RSK1 activation promotes invasion in nodular melanoma. Salhi A, et al. Am J Pathol, 2015 Mar. PMID 25579842, Free PMC Article
  5. p90 ribosomal S6 kinase 1 (RSK1) isoenzyme specifically regulates cytokinesis progression. Nam HJ, et al. Cell Signal, 2014 Feb. PMID 24269382

See all (231) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The ribosomal protein S6 kinase alpha-1 (RPS6KA1) induces resistance to venetoclax/azacitidine in acute myeloid leukemia.
    Title: The ribosomal protein S6 kinase alpha-1 (RPS6KA1) induces resistance to venetoclax/azacitidine in acute myeloid leukemia.
  2. Comprehensive analysis of the RSK gene family in acute myeloid leukemia determines a prognostic signature for the prediction of clinical prognosis and treatment responses.
    Title: Comprehensive analysis of the RSK gene family in acute myeloid leukemia determines a prognostic signature for the prediction of clinical prognosis and treatment responses.
  3. Associations of the Methylation Levels of NFAT5, PVT1, RPS6KA1, and MIB1 with Steroid-Resistant Asthma.
    Title: Associations of the Methylation Levels of NFAT5, PVT1, RPS6KA1, and MIB1 with Steroid-Resistant Asthma.
  4. Oncogenic KRAS engages an RSK1/NF1 pathway to inhibit wild-type RAS signaling in pancreatic cancer.
    Title: Oncogenic KRAS engages an RSK1/NF1 pathway to inhibit wild-type RAS signaling in pancreatic cancer.
  5. The Preeclamptic Environment Promotes the Activation of Transcription Factor Kappa B by P53/RSK1 Complex in a HTR8/SVneo Trophoblastic Cell Line.
    Title: The Preeclamptic Environment Promotes the Activation of Transcription Factor Kappa B by P53/RSK1 Complex in a HTR8/SVneo Trophoblastic Cell Line.
  6. MAP Kinase-Mediated Activation of RSK1 and MK2 Substrate Kinases.
    Title: MAP Kinase-Mediated Activation of RSK1 and MK2 Substrate Kinases.
  7. Pathway-Affecting Single Nucleotide Polymorphisms (SNPs) in RPS6KA1 and MBIP Genes are Associated with Breast Cancer Risk.
    Title: Pathway-Affecting Single Nucleotide Polymorphisms (SNPs) in RPS6KA1 and MBIP Genes are Associated with Breast Cancer Risk.
  8. Oxidative Stress Orchestrates MAPK and Nitric-Oxide Synthase Signal.
    Title: Oxidative Stress Orchestrates MAPK and Nitric-Oxide Synthase Signal.
  9. Aberrant expression of RSK1 characterizes high-grade gliomas with immune infiltration.
    Title: Aberrant expression of RSK1 characterizes high-grade gliomas with immune infiltration.
  10. Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion.
    Title: Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion.
Submit: New GeneRIF Correction See all GeneRIFs (84)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
  
enables protein serine/threonine/tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribosomal protein S6 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in chemical synaptic transmission TAS
Traceable Author Statement
more info
  
involved_in hepatocyte proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell differentiation TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cell growth TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of hepatic stellate cell activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of translation in response to stress TAS
Traceable Author Statement
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosomal protein S6 kinase alpha-1
Names
90 kDa ribosomal protein S6 kinase 1
MAP kinase-activated protein kinase 1a
MAPK-activated protein kinase 1a
MAPKAP kinase 1a
MAPKAPK-1a
RSK-1
S6K-alpha 1
dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1)
p90-RSK 1
p90RSK1
p90S6K
ribosomal S6 kinase 1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
NP_001006666.1
NP_001317370.1
NP_002944.2
XP_024304639.1
XP_047283214.1
XP_054187513.1
XP_054187514.1
XP_054194065.1
XP_054194066.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006665.2 → NP_001006666.1  ribosomal protein S6 kinase alpha-1 isoform b

    See identical proteins and their annotated locations for NP_001006666.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' end of the coding region compared to variant 1. These differences cause translation initiation at an in-frame AUG of an alternate exon and an isoform (b) with a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL627313
    Consensus CDS
    CCDS30649.1
    UniProtKB/TrEMBL
    E9PGT3
    Related
    ENSP00000435412.1, ENST00000531382.5
    Conserved Domains (4) summary
    smart00220
    Location:71 → 329
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:75 → 391
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14175
    Location:425 → 715
    STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)
    pfam00069
    Location:427 → 684
    Pkinase; Protein kinase domain

  2. NM_001330441.2 → NP_001317370.1  ribosomal protein S6 kinase alpha-1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' end of the coding region compared to variant 1. These differences cause translation initiation at an in-frame AUG of an alternate exon and an isoform (c) with a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL627313
    Consensus CDS
    CCDS81286.1
    UniProtKB/TrEMBL
    E9PGT3
    Related
    ENSP00000432281.1, ENST00000530003.5
    Conserved Domains (2) summary
    cd05582
    Location:50 → 366
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14175
    Location:400 → 690
    STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)

  3. NM_002953.4 → NP_002944.2  ribosomal protein S6 kinase alpha-1 isoform a

    See identical proteins and their annotated locations for NP_002944.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
    Source sequence(s)
    AL627313
    Consensus CDS
    CCDS284.1
    UniProtKB/Swiss-Prot
    A6NGG4, A8K9K7, B2RDY8, B7Z5J0, E9PRI4, Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2
    UniProtKB/TrEMBL
    E9PGT3
    Related
    ENSP00000363283.2, ENST00000374168.7
    Conserved Domains (2) summary
    cd05582
    Location:66 → 382
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14175
    Location:416 → 706
    STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    26529761..26575025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448871.2 → XP_024304639.1  ribosomal protein S6 kinase alpha-1 isoform X2

    UniProtKB/TrEMBL
    E9PGT3
    Related
    ENSP00000431651.1, ENST00000526792.5
    Conserved Domains (2) summary
    cd05582
    Location:1 → 290
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14175
    Location:324 → 614
    STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)

  2. XM_047427258.1 → XP_047283214.1  ribosomal protein S6 kinase alpha-1 isoform X1

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646195.1 Reference GRCh38.p14 PATCHES

    Range
    17379..62643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331539.1 → XP_054187514.1  ribosomal protein S6 kinase alpha-1 isoform X2

  2. XM_054331538.1 → XP_054187513.1  ribosomal protein S6 kinase alpha-1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    26367713..26412979
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338091.1 → XP_054194066.1  ribosomal protein S6 kinase alpha-1 isoform X2

  2. XM_054338090.1 → XP_054194065.1  ribosomal protein S6 kinase alpha-1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15418.2 GenPept UniProtKB/Swiss-Prot:Q15418

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