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Tnfsfm13 tumor necrosis factor (ligand) superfamily, membrane-bound member 13 [ Mus musculus (house mouse) ]

Gene ID: 619441, updated on 8-Feb-2024

Summary

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Official Symbol
Tnfsfm13provided by MGI
Official Full Name
tumor necrosis factor (ligand) superfamily, membrane-bound member 13provided by MGI
Primary source
MGI:MGI:3845075
See related
Ensembl:ENSMUSG00000018752 AllianceGenome:MGI:3845075
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Twe-pril; Tnfsf12Tnfsf13; Tnfsf12tnfsf13; Tnfsf12-Tnfsf13
Summary
This gene represents read-through transcription between neighboring genes encoding tumor necrosis factor family members. This results a hybrid protein composed of the cytoplasmic and transmembrane domains of family member 12 fused to the C-terminal domain of family member 13. The homologous fusion protein in human is known to be membrane-anchored and presents the receptor-binding domain of family member 13 at the cell surface. It stimulates cycling in T- and B-lymphoma cell lines. Alternative splicing of this mouse gene results in multiple transcript variants. [provided by RefSeq, Oct 2010]
Expression
Ubiquitous expression in lung adult (RPKM 21.3), ovary adult (RPKM 16.8) and 27 other tissues See more
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Genomic context

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Location:
11 B3; 11 42.86 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69573403..69586924, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69682577..69696098, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8419 Neighboring gene STARR-positive B cell enhancer ABC_E734 Neighboring gene eukaryotic translation initiation factor 4A1 Neighboring gene predicted gene, 22988 Neighboring gene SUMO/sentrin specific peptidase 3 Neighboring gene tumor necrosis factor (ligand) superfamily, member 13, opposite strand Neighboring gene tumor necrosis factor (ligand) superfamily, member 13 Neighboring gene tumor necrosis factor (ligand) superfamily, member 12 Neighboring gene STARR-seq mESC enhancer starr_29859 Neighboring gene STARR-seq mESC enhancer starr_29860 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide A Neighboring gene STARR-positive B cell enhancer ABC_E3966 Neighboring gene STARR-positive B cell enhancer ABC_E1830 Neighboring gene solute carrier family 35, member G3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein. Pradet-Balade B, et al. EMBO J, 2002 Nov 1. PMID 12411489, Free PMC Article
  2. TWE-PRIL reverse signalling suppresses sympathetic axon growth and tissue innervation. Howard L, et al. Development, 2018 Nov 19. PMID 30337376, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the first and physiologically relevant role for TWE-PRIL is reported and suggests that it mediates reverse signalling.
    Title: TWE-PRIL reverse signalling suppresses sympathetic axon growth and tissue innervation.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
tumor necrosis factor (ligand) superfamily, member 12-member 13
Names
Tnfsf12-Tnfsf13 readthrough transcript

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034097.2 → NP_001029269.1  tumor necrosis factor (ligand) superfamily, member 12-member 13 isoform a

    See identical proteins and their annotated locations for NP_001029269.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK044387
    UniProtKB/TrEMBL
    B0QZJ0, Q8BXS2
    Related
    ENSMUSP00000137973.2, ENSMUST00000180587.8
    Conserved Domains (2) summary
    cd00184
    Location:277 → 408
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
    cl00147
    Location:132 → 217
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

  2. NM_001159503.2 → NP_001152975.1  tumor necrosis factor (ligand) superfamily, member 12-member 13 isoform c

    See identical proteins and their annotated locations for NP_001152975.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate, in-frame splice sites in the coding region, compared to variant 1. The resulting isoform (c) lacks two residues, compared to isoform a.
    Source sequence(s)
    AL603707
    UniProtKB/TrEMBL
    B0QZJ0, Q5F2A1
    Related
    ENSMUSP00000133951.2, ENSMUST00000174159.8
    Conserved Domains (2) summary
    cd00184
    Location:276 → 406
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
    cl00147
    Location:131 → 216
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69573403..69586924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001034098.1: Suppressed sequence

    Description
    NM_001034098.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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