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RPL30 ribosomal protein L30 [ Homo sapiens (human) ]

Gene ID: 6156, updated on 7-Apr-2024

Summary

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Official Symbol
RPL30provided by HGNC
Official Full Name
ribosomal protein L30provided by HGNC
Primary source
HGNC:HGNC:10333
See related
Ensembl:ENSG00000156482 MIM:180467; AllianceGenome:HGNC:10333
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L30; eL30
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30E family of ribosomal proteins. It is located in the cytoplasm. This gene is co-transcribed with the U72 small nucleolar RNA gene, which is located in its fourth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 1597.1), lymph node (RPKM 816.8) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
8q22.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (98041721..98045545, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (99167205..99171037, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (99053949..99057773, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:98880393-98880892 Neighboring gene ribosomal protein S23 pseudogene 1 Neighboring gene matrilin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:98909071-98909570 Neighboring gene uncharacterized LOC124901987 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:98962761-98963312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:98963313-98963863 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:99019619-99020119 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:99023104-99023762 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_103766 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_103770 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:99044769-99045968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27672 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:99057921-99058857 Neighboring gene small nucleolar RNA, H/ACA box 72 Neighboring gene RNA, U6 small nuclear 703, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27675 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19394 Neighboring gene glutamate rich 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27676

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Crystallization and preliminary X-ray structure analysis of human ribosomal protein L30e. Kawaguchi A, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011 Dec 1. PMID 22139155, Free PMC Article
  2. Transcriptional regulation of serine/threonine protein kinase (AKT) genes by glioma-associated oncogene homolog 1. Agarwal NK, et al. J Biol Chem, 2013 May 24. PMID 23580656, Free PMC Article
  3. Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8. De Bortoli M, et al. BMC Cancer, 2006 Sep 12. PMID 16968546, Free PMC Article
  4. Perturbation of 60 S ribosomal biogenesis results in ribosomal protein L5- and L11-dependent p53 activation. Sun XX, et al. J Biol Chem, 2010 Aug 13. PMID 20554519, Free PMC Article
  5. The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome. Feo S, et al. Genomics, 1992 May. PMID 1577483

See all (183) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. crystal of L30e diffracted to 1.6 A degrees resolution
    Title: Crystallization and preliminary X-ray structure analysis of human ribosomal protein L30e.
  2. Knockdown of L29 or L30 enhanced the interaction of MDM2 with L11 and L5 and markedly inhibited MDM2-mediated p53 ubiquitination, suggesting that direct perturbation of 60 S ribosomal biogenesis activates p53 via L11- and L5-mediated MDM2 suppression.
    Title: Perturbation of 60 S ribosomal biogenesis results in ribosomal protein L5- and L11-dependent p53 activation.
  3. Gain of 8q-mapped RPL30 gene is associated with adverse outcome in Medulloblastoma.
    Title: Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human 60S ribosomal protein L30 (RPL30) at amino acid residues 92-93 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
enables structural constituent of ribosome TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in cytoplasmic translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in killing of cells of another organism IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit HDA PubMed 
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of cytosolic large ribosomal subunit TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in focal adhesion HDA PubMed 
located_in membrane HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density EXP
Inferred from Experiment
more info
 PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
large ribosomal subunit protein eL30
Names
60S ribosomal protein L30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000989.4 → NP_000980.1  large ribosomal subunit protein eL30

    See identical proteins and their annotated locations for NP_000980.1

    Status: REVIEWED

    Source sequence(s)
    BC095426, BM785413
    Consensus CDS
    CCDS34928.1
    UniProtKB/Swiss-Prot
    B2R591, P04645, P62888, Q502Z6
    UniProtKB/TrEMBL
    E5RI99
    Related
    ENSP00000287038.3, ENST00000287038.8
    Conserved Domains (1) summary
    PTZ00106
    Location:2 → 107
    PTZ00106; 60S ribosomal protein L30; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    98041721..98045545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    99167205..99171037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62888.2 GenPept UniProtKB/Swiss-Prot:P62888

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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