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RPL6 ribosomal protein L6 [ Homo sapiens (human) ]

Gene ID: 6128, updated on 7-Apr-2024

Summary

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Official Symbol
RPL6provided by HGNC
Official Full Name
ribosomal protein L6provided by HGNC
Primary source
HGNC:HGNC:10362
See related
Ensembl:ENSG00000089009 MIM:603703; AllianceGenome:HGNC:10362
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L6; eL6; TXREB1; SHUJUN-2; TAXREB107
Summary
This gene encodes a protein component of the 60S ribosomal subunit. This protein can bind specifically to domain C of the tax-responsive enhancer element of human T-cell leukemia virus type 1, and may participate in tax-mediated transactivation of transcription. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in ovary (RPKM 360.8), lymph node (RPKM 224.8) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
12q24.13
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (112405181..112418835, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (112382081..112395752, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (112842985..112856639, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene HECT domain E3 ubiquitin protein ligase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7048 Neighboring gene ribosomal protein L7a pseudogene 60 Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 2 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:112818193-112818693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4883 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:112819879-112820378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7049 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:112855308-112855956 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:112855957-112856604 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:112856605-112857252 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:112876497-112876700 Neighboring gene protein tyrosine phosphatase non-receptor type 11 Neighboring gene uncharacterized LOC124903023 Neighboring gene uncharacterized LOC124903024

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. 60S ribosomal proteins L6 (RPL6) and RPL28, which are adjacent on the ribosome, play opposite roles in generating an influenza A virus-encoded peptide. Depleting RPL6 decreases ubiquitin-dependent peptide presentation, whereas depleting RPL28 increases ubiquitin-dependent and -independent peptide presentation.
    Title: Ribosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance.
  2. The ribosomal protein L6 binds to and suppresses the E3 ubiquitin ligase activity of HDM2, and subsequently attenuates HDM2-mediated p53 polyubiquitination and degradation.
    Title: Regulation of the HDM2-p53 pathway by ribosomal protein L6 in response to ribosomal stress.
  3. Down-regulation of RPL6 could suppress cell growth and cell cycle progression at least through down-regulating cyclin E
    Title: Downregulation of RPL6 by siRNA inhibits proliferation and cell cycle progression of human gastric cancer cell lines.
  4. RPL6 was overexpressed in human gastric cancer and its over-expression could promote cell growth and cell cycle progression at least through upregulating cyclin E expression.
    Title: Ribosomal protein L6 promotes growth and cell cycle progression through upregulating cyclin E in gastric cancer cells.
  5. The high expression of RPL6/Taxreb107 in drug resistant gastric cancer cell shows its correlation with multiple-drug resistance in gastric cancer.
    Title: [Differential expression of RPL6/Taxreb107 in drug resistant gastric cancer cell line SGC7901/ADR and its correlation with multiple-drug resistance].
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L6 (RPL6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L6 (RPL6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L6 (RPL6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L6 (RPL6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev HIV-1 Rev interacting protein, ribosomal protein L6 (RPL6), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human 60S ribosomal protein L6 (RPL6) at amino acid residues 88-89 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadherin binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in cytoplasmic translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
involved_in ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit HDA PubMed 
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in focal adhesion HDA PubMed 
located_in membrane HDA PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  
located_in rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein eL6
Names
60S ribosomal protein L6
DNA-binding protein TAXREB107
neoplasm-related protein C140
tax-responsive enhancer element-binding protein 107

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000970.6 → NP_000961.2  large ribosomal subunit protein eL6 isoform 1

    See identical proteins and their annotated locations for NP_000961.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is the predominant variant. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same isoform (1).
    Source sequence(s)
    AI583261, BC004138
    Consensus CDS
    CCDS9162.1
    UniProtKB/Swiss-Prot
    Q02878, Q2M3Q3, Q8WW97
    UniProtKB/TrEMBL
    B2R4K7
    Related
    ENSP00000202773.9, ENST00000202773.14
    Conserved Domains (2) summary
    cd13156
    Location:136 → 288
    KOW_RPL6; KOW motif of Ribosomal Protein L6
    pfam03868
    Location:36 → 95
    Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain

  2. NM_001024662.3 → NP_001019833.1  large ribosomal subunit protein eL6 isoform 1

    See identical proteins and their annotated locations for NP_001019833.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same isoform (1).
    Source sequence(s)
    AI583261, BC004138, BC022444, BP285025
    Consensus CDS
    CCDS9162.1
    UniProtKB/Swiss-Prot
    Q02878, Q2M3Q3, Q8WW97
    UniProtKB/TrEMBL
    B2R4K7
    Related
    ENSP00000403172.2, ENST00000424576.6
    Conserved Domains (2) summary
    cd13156
    Location:136 → 288
    KOW_RPL6; KOW motif of Ribosomal Protein L6
    pfam03868
    Location:36 → 95
    Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain

  3. NM_001320137.2 → NP_001307066.1  large ribosomal subunit protein eL6 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same isoform (1).
    Source sequence(s)
    AI583261, BC004138, BP285025, CB140996, CD049618
    Consensus CDS
    CCDS9162.1
    UniProtKB/Swiss-Prot
    Q02878, Q2M3Q3, Q8WW97
    UniProtKB/TrEMBL
    B2R4K7
    Conserved Domains (2) summary
    cd13156
    Location:136 → 288
    KOW_RPL6; KOW motif of Ribosomal Protein L6
    pfam03868
    Location:36 → 95
    Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain

  4. NM_001320138.2 → NP_001307067.1  large ribosomal subunit protein eL6 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same isoform (1).
    Source sequence(s)
    AI583261, BC004138, BP308263
    Consensus CDS
    CCDS9162.1
    UniProtKB/Swiss-Prot
    Q02878, Q2M3Q3, Q8WW97
    UniProtKB/TrEMBL
    B2R4K7
    Conserved Domains (2) summary
    cd13156
    Location:136 → 288
    KOW_RPL6; KOW motif of Ribosomal Protein L6
    pfam03868
    Location:36 → 95
    Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain

  5. NM_001320139.2 → NP_001307068.1  large ribosomal subunit protein eL6 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same isoform (1).
    Source sequence(s)
    AI583261, BC004138, CD688935, HY016219
    Consensus CDS
    CCDS9162.1
    UniProtKB/Swiss-Prot
    Q02878, Q2M3Q3, Q8WW97
    UniProtKB/TrEMBL
    B2R4K7
    Conserved Domains (2) summary
    cd13156
    Location:136 → 288
    KOW_RPL6; KOW motif of Ribosomal Protein L6
    pfam03868
    Location:36 → 95
    Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain

  6. NM_001320140.2 → NP_001307069.1  large ribosomal subunit protein eL6 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same isoform (1).
    Source sequence(s)
    AI583261, BC004138, CD640506, CD688935
    Consensus CDS
    CCDS9162.1
    UniProtKB/Swiss-Prot
    Q02878, Q2M3Q3, Q8WW97
    UniProtKB/TrEMBL
    B2R4K7
    Conserved Domains (2) summary
    cd13156
    Location:136 → 288
    KOW_RPL6; KOW motif of Ribosomal Protein L6
    pfam03868
    Location:36 → 95
    Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain

  7. NM_001320141.2 → NP_001307070.1  large ribosomal subunit protein eL6 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an exon and contains three alternate exons in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same isoform (1).
    Source sequence(s)
    AI583261, BC004138, BG722198
    Consensus CDS
    CCDS9162.1
    UniProtKB/Swiss-Prot
    Q02878, Q2M3Q3, Q8WW97
    UniProtKB/TrEMBL
    B2R4K7
    Conserved Domains (2) summary
    cd13156
    Location:136 → 288
    KOW_RPL6; KOW motif of Ribosomal Protein L6
    pfam03868
    Location:36 → 95
    Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain

  8. NM_001320142.1 → NP_001307071.1  large ribosomal subunit protein eL6 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AI583261, BG030827, HY038019
    Conserved Domains (1) summary
    cd13156
    Location:25 → 177
    KOW_RPL6; KOW motif of Ribosomal Protein L6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    112405181..112418835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429303.1 → XP_047285259.1  large ribosomal subunit protein eL6 isoform X1

    UniProtKB/Swiss-Prot
    Q02878, Q2M3Q3, Q8WW97

  2. XM_047429304.1 → XP_047285260.1  large ribosomal subunit protein eL6 isoform X2

  3. XM_047429302.1 → XP_047285258.1  large ribosomal subunit protein eL6 isoform X1

    UniProtKB/Swiss-Prot
    Q02878, Q2M3Q3, Q8WW97

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    112382081..112395752 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372828.1 → XP_054228803.1  large ribosomal subunit protein eL6 isoform X1

    UniProtKB/Swiss-Prot
    Q02878, Q2M3Q3, Q8WW97

  2. XM_054372830.1 → XP_054228805.1  large ribosomal subunit protein eL6 isoform X1

    UniProtKB/Swiss-Prot
    Q02878, Q2M3Q3, Q8WW97

  3. XM_054372831.1 → XP_054228806.1  large ribosomal subunit protein eL6 isoform X2

  4. XM_054372829.1 → XP_054228804.1  large ribosomal subunit protein eL6 isoform X1

    UniProtKB/Swiss-Prot
    Q02878, Q2M3Q3, Q8WW97
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02878.3 GenPept UniProtKB/Swiss-Prot:Q02878

Gene LinkOut

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