Npvf neuropeptide VF precursor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Npvfprovided by MGI
Official Full Name: neuropeptide VF precursorprovided by MGI
Primary source: MGI:MGI:1926488
See related: Ensembl:ENSMUSG00000029831 AllianceGenome:MGI:1926488
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rfrp
Summary: Predicted to enable signaling receptor binding activity. Predicted to be involved in negative regulation of gonadotropin secretion; neuropeptide signaling pathway; and sensory perception of pain. Predicted to be located in extracellular region. Is expressed in brain; cerebral cortex; dorsomedial hypothalamic nucleus; hypothalamus; and hypothalamus mantle layer. Orthologous to human NPVF (neuropeptide VF precursor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 6 B2.3; 6 24.34 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (50627652..50631425, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (50650672..50654445, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Thyroid hormone receptors are required for the melatonin-dependent control of Rfrp gene expression in mice.
Title: Thyroid hormone receptors are required for the melatonin-dependent control of Rfrp gene expression in mice.
These data, together with gene expression in multiple tissues, provide strong confidence that RFRP-immunoreactive neuronal cells are localised in the dorsomedial hypothalamic nucleus (DMH) and between the DMH and the ventromedial hypothalamic nuclei.
Title: Isolation and identification of endogenous RFamide-related peptides 1 and 3 in the mouse hypothalamus.
Our observations suggest that RFRP-3 might be involved in positive feedback regulation by directly or indirectly increasing Kiss-1 gene expression.
Title: Role of RFRP-3 in the Regulation of Kiss-1 Gene Expression in the AVPV Hypothalamic Cell Model mHypoA-50.
RFRP-3 activated PI3K/AKT and ERK1/2 signaling cascades and promotes pancreatic alpha cell survival, likely via GPR147.
Title: RFamide-related peptide-3 promotes alpha TC1 clone 6 cell survival likely via GPR147.
Hypothyroidism showed delayed pubertal onset with increased GnIH expression and reduced pituitary-gonadal activity.
Title: Involvement of gonadotropin-inhibitory hormone in pubertal disorders induced by thyroid status.
findings suggest that the suppressive signalling of RFRP-3 on Gonadotrophin releasing hormone transcription may dominate over kisspeptin induction in the mHypoA-GnRH/GFP Gonadotrophin releasing hormone neuronal cell model.
Title: Direct regulation of gonadotrophin-releasing hormone (GnRH) transcription by RF-amide-related peptide-3 and kisspeptin in a novel GnRH-secreting cell line, mHypoA-GnRH/GFP.
RF-amide-related peptide-3 (RFRP-3), the mammalian ortholog of the avian gonadotropin-inhibiting hormone (GnIH), operates via the NPFF1 receptor (NPFF1R) to repress the reproductive axis.
Title: Physiological roles of gonadotropin-inhibitory hormone signaling in the control of mammalian reproductive axis: studies in the NPFF1 receptor null mouse.
RFRP-3 may exert its effects on reproduction either directly, via Gpr147 in a subset of GnRH neurons, and/or indirectly, via upstream regulators of GnRH.
Title: Development, sex steroid regulation, and phenotypic characterization of RFamide-related peptide (Rfrp) gene expression and RFamide receptors in the mouse hypothalamus.
Interaction between GnRH I-RFRP-3 neuropeptides may be involved in the regulation of follicular development and atresia.
Title: Immunohistochemical localization of GnRH and RFamide-related peptide-3 in the ovaries of mice during the estrous cycle.
It is concluded that aging mice exhibits inverse correlation of RFRP-3 neurons and gonadal activity suggesting that function of RFRP-3 is not initiated until 1-week of age and thereafter it could participate in the regulation of gonadal development.
Title: Age-dependent variation in the RFRP-3 neurons is inversely correlated with gonadal activity of mice.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of gonadotropin secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of gonadotropin secretion	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pro-FMRFamide-related neuropeptide VF

Names: FMRFamide-related peptides; RFamide-related peptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.