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Fignl1 fidgetin-like 1 [ Mus musculus (house mouse) ]

Gene ID: 60530, updated on 11-Apr-2024

Summary

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Official Symbol
Fignl1provided by MGI
Official Full Name
fidgetin-like 1provided by MGI
Primary source
MGI:MGI:1890648
See related
Ensembl:ENSMUSG00000035455 AllianceGenome:MGI:1890648
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable microtubule-severing ATPase activity. Involved in several processes, including male meiotic nuclear division; osteoblast differentiation; and osteoblast proliferation. Acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway. Located in nucleus and perinuclear region of cytoplasm. Is expressed in brain ventricular layer and inferior colliculus. Orthologous to human FIGNL1 (fidgetin like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 22.0), liver E14.5 (RPKM 18.3) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Fignl1 in Genome Data Viewer
Location:
11 A1; 11 7.08 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (11737429..11758962, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (11800288..11808983, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:11557248-11557441 Neighboring gene predicted gene 11999 Neighboring gene STARR-positive B cell enhancer mm9_chr11:11590032-11590333 Neighboring gene IKAROS family zinc finger 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:11611793-11612034 Neighboring gene predicted gene 12000 Neighboring gene STARR-positive B cell enhancer ABC_E5207 Neighboring gene STARR-positive B cell enhancer ABC_E3931 Neighboring gene STARR-positive B cell enhancer mm9_chr11:11666148-11666448 Neighboring gene STARR-positive B cell enhancer ABC_E6952 Neighboring gene STARR-seq mESC enhancer starr_28598 Neighboring gene STARR-seq mESC enhancer starr_28601 Neighboring gene STARR-seq mESC enhancer starr_28602 Neighboring gene dopa decarboxylase Neighboring gene predicted gene, 51937 Neighboring gene RIKEN cDNA 1700042O10 gene Neighboring gene STARR-seq mESC enhancer starr_28608

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Microtubule-severing protein Fidgetin-like 1 promotes spindle organization during meiosis of mouse oocytes. Shou HF, et al. Zygote, 2022 Dec. PMID 36148793
  2. mRNA expression analysis of cell cycle genes in islets of pregnant mice. Schraenen A, et al. Diabetologia, 2010 Dec. PMID 20886204, Free PMC Article
  3. Fidgetin-like 1 gene inhibited by basic fibroblast growth factor regulates the proliferation and differentiation of osteoblasts. Park SJ, et al. J Bone Miner Res, 2007 Jun. PMID 17352653
  4. Fidgetin-like1 is a strong candidate for a dynamic impairment of male meiosis leading to reduced testis weight in mice. L'Hôte D, et al. PLoS One, 2011. PMID 22110678, Free PMC Article
  5. Paternal deletion of Meg1/Grb10 DMR causes maternalization of the Meg1/Grb10 cluster in mouse proximal Chromosome 11 leading to severe pre- and postnatal growth retardation. Shiura H, et al. Hum Mol Genet, 2009 Apr 15. PMID 19174477

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination.
    Title: FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination.
  2. The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart.
    Title: The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart.
  3. Microtubule-severing protein Fidgetin-like 1 promotes spindle organization during meiosis of mouse oocytes.
    Title: Microtubule-severing protein Fidgetin-like 1 promotes spindle organization during meiosis of mouse oocytes.
  4. Fignl1 as a novel actor in mammal's male meiosis dynamics
    Title: Fidgetin-like1 is a strong candidate for a dynamic impairment of male meiosis leading to reduced testis weight in mice.
  5. FIGNL1, a subfamily member of the AAA family of proteins, might play some regulatory role in osteoblast proliferation and differentiation.
    Title: Fidgetin-like 1 gene inhibited by basic fibroblast growth factor regulates the proliferation and differentiation of osteoblasts.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule severing ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in male meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in osteoblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
fidgetin-like protein 1
NP_001156831.1
NP_001156832.1
NP_001412580.1
NP_001412581.1
NP_001412582.1
NP_001412583.1
NP_001412584.1
NP_001412585.1
NP_001412586.1
NP_001412587.1
NP_001412588.1
NP_068691.2
XP_036012780.1
XP_036012781.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163359.2 → NP_001156831.1  fidgetin-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001156831.1

    Status: VALIDATED

    Source sequence(s)
    AL596450
    Consensus CDS
    CCDS24438.1
    UniProtKB/Swiss-Prot
    Q3UF48, Q8BPY9, Q8C2I6, Q9ERZ5
    Related
    ENSMUSP00000126340.2, ENSMUST00000171938.2
    Conserved Domains (3) summary
    pfam09336
    Location:640 → 680
    Vps4_C; Vps4 C terminal oligomerization domain
    pfam17862
    Location:599 → 630
    AAA_lid_3; AAA+ lid domain
    cd19525
    Location:389 → 574
    RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)

  2. NM_001163360.1 → NP_001156832.1  fidgetin-like protein 1

    See identical proteins and their annotated locations for NP_001156832.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK051874, AK143850, BY231020, CN693395
    Consensus CDS
    CCDS24438.1
    UniProtKB/Swiss-Prot
    Q3UF48, Q8BPY9, Q8C2I6, Q9ERZ5
    Related
    ENSMUSP00000127489.2, ENSMUST00000171080.8
    Conserved Domains (3) summary
    pfam09336
    Location:640 → 680
    Vps4_C; Vps4 C terminal oligomerization domain
    pfam17862
    Location:599 → 630
    AAA_lid_3; AAA+ lid domain
    cd19525
    Location:389 → 574
    RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)

  3. NM_001425651.1 → NP_001412580.1  fidgetin-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL596450

  4. NM_001425652.1 → NP_001412581.1  fidgetin-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL596450

  5. NM_001425653.1 → NP_001412582.1  fidgetin-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL596450
    UniProtKB/Swiss-Prot
    Q3UF48, Q8BPY9, Q8C2I6, Q9ERZ5

  6. NM_001425654.1 → NP_001412583.1  fidgetin-like protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL596450

  7. NM_001425655.1 → NP_001412584.1  fidgetin-like protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL596450

  8. NM_001425656.1 → NP_001412585.1  fidgetin-like protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL596450

  9. NM_001425657.1 → NP_001412586.1  fidgetin-like protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL596450

  10. NM_001425658.1 → NP_001412587.1  fidgetin-like protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL596450

  11. NM_001425659.1 → NP_001412588.1  fidgetin-like protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL596450

  12. NM_021891.4 → NP_068691.2  fidgetin-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_068691.2

    Status: VALIDATED

    Source sequence(s)
    AL596450
    Consensus CDS
    CCDS24438.1
    UniProtKB/Swiss-Prot
    Q3UF48, Q8BPY9, Q8C2I6, Q9ERZ5
    Related
    ENSMUSP00000036932.5, ENSMUST00000047689.11
    Conserved Domains (3) summary
    pfam09336
    Location:640 → 680
    Vps4_C; Vps4 C terminal oligomerization domain
    pfam17862
    Location:599 → 630
    AAA_lid_3; AAA+ lid domain
    cd19525
    Location:389 → 574
    RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)

RNA

  1. NR_189574.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL596450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    11737429..11758962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156888.1 → XP_036012781.1  fidgetin-like protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q3UF48, Q8BPY9, Q8C2I6, Q9ERZ5
    Conserved Domains (3) summary
    pfam09336
    Location:640 → 680
    Vps4_C; Vps4 C terminal oligomerization domain
    pfam17862
    Location:599 → 630
    AAA_lid_3; AAA+ lid domain
    cd19525
    Location:389 → 574
    RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)

  2. XM_036156887.1 → XP_036012780.1  fidgetin-like protein 1 isoform X1

    Conserved Domains (3) summary
    pfam09336
    Location:649 → 689
    Vps4_C; Vps4 C terminal oligomerization domain
    pfam17862
    Location:608 → 639
    AAA_lid_3; AAA+ lid domain
    cd19525
    Location:398 → 583
    RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BPY9.1 GenPept UniProtKB/Swiss-Prot:Q8BPY9

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