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Qtrt1 queuine tRNA-ribosyltransferase catalytic subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 60507, updated on 5-Mar-2024

Summary

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Official Symbol
Qtrt1provided by MGI
Official Full Name
queuine tRNA-ribosyltransferase catalytic subunit 1provided by MGI
Primary source
MGI:MGI:1931441
See related
Ensembl:ENSMUSG00000002825 AllianceGenome:MGI:1931441
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tgt; 2610028E17Rik
Summary
Enables queuine tRNA-ribosyltransferase activity. Involved in tRNA-guanine transglycosylation. Located in cytoplasm and nucleus. Part of protein-containing complex. Colocalizes with mitochondrion. Is expressed in several structures, including alimentary system; facial bone primordium; nervous system; respiratory system; and urinary system. Orthologous to human QTRT1 (queuine tRNA-ribosyltransferase catalytic subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 12.5), limb E14.5 (RPKM 10.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A3; 9 7.79 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21323096..21331575)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21411801..21420279)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36198 Neighboring gene interleukin enhancer binding factor 3 Neighboring gene STARR-positive B cell enhancer ABC_E2284 Neighboring gene predicted gene, 16853 Neighboring gene STARR-positive B cell enhancer ABC_E134 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:21240723-21240906 Neighboring gene dynamin 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:21254333-21254586 Neighboring gene predicted gene, 46104 Neighboring gene predicted gene, 57796 Neighboring gene microRNA 199a-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Queuosine deficiency in eukaryotes compromises tyrosine production through increased tetrahydrobiopterin oxidation. Rakovich T, et al. J Biol Chem, 2011 Jun 3. PMID 21487017, Free PMC Article
  2. Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase. Sebastiani M, et al. ACS Chem Biol, 2022 Aug 19. PMID 35815944
  3. In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis. Varghese S, et al. Nucleic Acids Res, 2017 Feb 28. PMID 28204548, Free PMC Article
  4. Queuine links translational control in eukaryotes to a micronutrient from bacteria. Müller M, et al. Nucleic Acids Res, 2019 Apr 23. PMID 30715423, Free PMC Article
  5. Queuosine formation in eukaryotic tRNA occurs via a mitochondria-localized heteromeric transglycosylase. Boland C, et al. J Biol Chem, 2009 Jul 3. PMID 19414587, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase.
    Title: Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables pentosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA-guanosine(34) queuine transglycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA-guanosine(34) queuine transglycosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA-guanosine(34) queuine transglycosylase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tRNA modification IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA-guanine transglycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA-guanine transglycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA-guanine transglycosylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of transferase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
queuine tRNA-ribosyltransferase catalytic subunit 1
Names
guanine insertion enzyme
queuine tRNA-ribosyltransferase 1
tRNA-guanine transglycosylase
NP_068688.2
XP_006510587.1
XP_011240885.1
XP_036011059.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021888.2 → NP_068688.2  queuine tRNA-ribosyltransferase catalytic subunit 1

    See identical proteins and their annotated locations for NP_068688.2

    Status: VALIDATED

    Source sequence(s)
    AB034632, AI842405, BY291101
    Consensus CDS
    CCDS52735.1
    UniProtKB/Swiss-Prot
    Q80VS3, Q9JMA2
    Related
    ENSMUSP00000002902.7, ENSMUST00000002902.8
    Conserved Domains (1) summary
    pfam01702
    Location:26 → 381
    TGT; Queuine tRNA-ribosyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    21323096..21331575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510524.5 → XP_006510587.1  queuine tRNA-ribosyltransferase catalytic subunit 1 isoform X2

    Conserved Domains (1) summary
    pfam01702
    Location:26 → 287
    TGT; Queuine tRNA-ribosyltransferase

  2. XM_036155166.1 → XP_036011059.1  queuine tRNA-ribosyltransferase catalytic subunit 1 isoform X1

    Conserved Domains (1) summary
    pfam01702
    Location:1 → 286
    TGT; Queuine tRNA-ribosyltransferase

  3. XM_011242583.2 → XP_011240885.1  queuine tRNA-ribosyltransferase catalytic subunit 1 isoform X3

    Conserved Domains (1) summary
    pfam01702
    Location:28 → 194
    TGT; Queuine tRNA-ribosyltransferase

RNA

  1. XR_003947961.2 RNA Sequence

  2. XR_003947960.2 RNA Sequence

  3. XR_379128.5 RNA Sequence

  4. XR_001778954.3 RNA Sequence

  5. XR_004935511.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JMA2.2 GenPept UniProtKB/Swiss-Prot:Q9JMA2

Gene LinkOut

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