Pgap6 post-glycosylphosphatidylinositol attachment to proteins 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pgap6provided by MGI
Official Full Name: post-glycosylphosphatidylinositol attachment to proteins 6provided by MGI
Primary source: MGI:MGI:1926283
See related: Ensembl:ENSMUSG00000024180 AllianceGenome:MGI:1926283
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: M83; Tmem8; Rxylt1; Tmem8a; GPI-PLA2
Summary: Predicted to enable phospholipase A2 activity. Predicted to be located in lysosome and membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in cranial ganglion; genitourinary system; gut; lung; and olfactory epithelium. Orthologous to human PGAP6 (post-glycosylphosphatidylinositol attachment to proteins 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in kidney adult (RPKM 98.6), testis adult (RPKM 76.1) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 13.06 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (26332290..26342228)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (26112752..26123254)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PGAP6 plays a critical role in Nodal signaling modulation through CRIPTO shedding.
Title: A GPI processing phospholipase A2, PGAP6, modulates Nodal signaling in embryos by shedding CRIPTO.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables phospholipase A2 activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: post-GPI attachment to proteins factor 6

Names: GPI processing phospholipase A2; ribitol xylosyltransferase 1; transmembrane protein 6; transmembrane protein 8 (five membrane-spanning domains); transmembrane protein 8A; type I transmembrane protein

NP_068565.1

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.