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Il1rapl2 interleukin 1 receptor accessory protein-like 2 [ Mus musculus (house mouse) ]

Gene ID: 60367, updated on 11-Apr-2024

Summary

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Official Symbol
Il1rapl2provided by MGI
Official Full Name
interleukin 1 receptor accessory protein-like 2provided by MGI
Primary source
MGI:MGI:1913106
See related
Ensembl:ENSMUSG00000059203 AllianceGenome:MGI:1913106
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable NAD(P)+ nucleosidase activity; NAD+ nucleotidase, cyclic ADP-ribose generating; and interleukin-1, type II, blocking receptor activity. Predicted to be involved in regulation of presynapse assembly. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in glutamatergic synapse. Is expressed in brain and spinal cord floor plate. Orthologous to human IL1RAPL2 (interleukin 1 receptor accessory protein like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Il1rapl2 in Genome Data Viewer
Location:
X F1; X 59.1 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (136471503..137749826)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (137570754..138849077)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47981 Neighboring gene zinc finger, ZZ domain containing 3 pseudogene Neighboring gene predicted gene 8036 Neighboring gene STARR-seq mESC enhancer starr_47982 Neighboring gene STARR-seq mESC enhancer starr_47983 Neighboring gene protein transport protein Sec61 subunit gamma pseudogene Neighboring gene testis expressed 13A Neighboring gene predicted gene, 22057 Neighboring gene predicted gene, 23958 Neighboring gene STARR-seq mESC enhancer starr_47984 Neighboring gene STARR-seq mESC enhancer starr_47985 Neighboring gene STARR-seq mESC enhancer starr_47986 Neighboring gene zinc finger protein 259 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47988 Neighboring gene zinc finger CCCH type containing 14 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47989 Neighboring gene serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 Neighboring gene Nik related kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. IL1RAPL2 maps to Xq22 and is specifically expressed in the central nervous system. Ferrante MI, et al. Gene, 2001 Sep 19. PMID 11587848
  2. Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling. Born TL, et al. J Biol Chem, 2000 Sep 29. PMID 10882729
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-1, type II, blocking receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of presynapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
X-linked interleukin-1 receptor accessory protein-like 2
Names
IL-1 receptor accessory protein-like 2
IL-1-RAPL-2
IL-1RAPL-2
IL1RAPL-2
IL1RAPL-2-related protein
TIGIRR-1
three immunoglobulin domain-containing IL-1 receptor-related 1
NP_109613.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030688.2 → NP_109613.1  X-linked interleukin-1 receptor accessory protein-like 2 precursor

    See identical proteins and their annotated locations for NP_109613.1

    Status: VALIDATED

    Source sequence(s)
    AK045976, AL672067
    Consensus CDS
    CCDS30429.1
    UniProtKB/Swiss-Prot
    Q9ER66, Q9ERS6
    UniProtKB/TrEMBL
    Q0VBP3
    Related
    ENSMUSP00000108686.2, ENSMUST00000113063.8
    Conserved Domains (4) summary
    cd05896
    Location:32 → 133
    Ig1_IL1RAPL-1_like; First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1)
    smart00255
    Location:401 → 559
    TIR; Toll - interleukin 1 - resistance
    smart00410
    Location:250 → 347
    IG_like; Immunoglobulin like
    cd05757
    Location:146 → 237
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    136471503..137749826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ERS6.1 GenPept UniProtKB/Swiss-Prot:Q9ERS6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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