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Rbm8a RNA binding motif protein 8a [ Mus musculus (house mouse) ]

Gene ID: 60365, updated on 31-Mar-2024

Summary

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Official Symbol
Rbm8aprovided by MGI
Official Full Name
RNA binding motif protein 8aprovided by MGI
Primary source
MGI:MGI:1913129
See related
Ensembl:ENSMUSG00000038374 AllianceGenome:MGI:1913129
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rbm8; 2310057C03Rik
Summary
Enables mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; and regulation of alternative mRNA splicing, via spliceosome. Located in nucleus. Is expressed in several structures, including central nervous system; future brain; and olfactory epithelium. Human ortholog(s) of this gene implicated in thrombocytopenia-absent radius syndrome. Orthologous to human RBM8A (RNA binding motif protein 8A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 30.4), CNS E14 (RPKM 14.6) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F2.1; 3 41.93 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96537244..96541107)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96629928..96633791)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 34A Neighboring gene predicted gene, 52628 Neighboring gene RIKEN cDNA 6330549D23 gene Neighboring gene Lix1-like Neighboring gene STARR-positive B cell enhancer ABC_E7929 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:96439383-96439492 Neighboring gene peroxisomal biogenesis factor 11 beta Neighboring gene integrin, alpha 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcriptomic Analyses of Brains of RBM8A Conditional Knockout Mice at Different Developmental Stages Reveal Conserved Signaling Pathways Contributing to Neurodevelopmental Diseases. McSweeney C, et al. Int J Mol Sci, 2023 Feb 27. PMID 36902031, Free PMC Article
  2. High-salt diet blunts renal autoregulation by a reactive oxygen species-dependent mechanism. Fellner RC, et al. Am J Physiol Renal Physiol, 2014 Jul 1. PMID 24872316, Free PMC Article
  3. An EJC factor RBM8a regulates anxiety behaviors. Alachkar A, et al. Curr Mol Med, 2013 Jul. PMID 23638902
  4. RBM8A Depletion Decreases the Cisplatin Resistance and Represses the Proliferation and Metastasis of Breast Cancer Cells via AKT/mTOR Pathway. Song T, et al. Breast J, 2022. PMID 36105365, Free PMC Article
  5. miR-29a regulates the proliferation and differentiation of retinal progenitors by targeting Rbm8a. Zhang Y, et al. Oncotarget, 2017 May 9. PMID 28404883, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Exon Junction Complex Factor RBM8A in Glial Fibrillary Acid Protein-Expressing Astrocytes Modulates Locomotion Behaviors.
    Title: The Exon Junction Complex Factor RBM8A in Glial Fibrillary Acid Protein-Expressing Astrocytes Modulates Locomotion Behaviors.
  2. Transcriptomic Analyses of Brains of RBM8A Conditional Knockout Mice at Different Developmental Stages Reveal Conserved Signaling Pathways Contributing to Neurodevelopmental Diseases.
    Title: Transcriptomic Analyses of Brains of RBM8A Conditional Knockout Mice at Different Developmental Stages Reveal Conserved Signaling Pathways Contributing to Neurodevelopmental Diseases.
  3. RBM8A Depletion Decreases the Cisplatin Resistance and Represses the Proliferation and Metastasis of Breast Cancer Cells via AKT/mTOR Pathway.
    Title: RBM8A Depletion Decreases the Cisplatin Resistance and Represses the Proliferation and Metastasis of Breast Cancer Cells via AKT/mTOR Pathway.
  4. Full function of exon junction complex factor, Rbm8a, is critical for interneuron development.
    Title: Full function of exon junction complex factor, Rbm8a, is critical for interneuron development.
  5. our data demonstrate that miR-29a regulates the proliferation and differentiation of RPCs by directly targeting Rbm8a, providing us with a better understanding of the molecular mechanisms that govern RPC proliferation and differentiation.
    Title: miR-29a regulates the proliferation and differentiation of retinal progenitors by targeting Rbm8a.
  6. Data suggest that, in embryonic stem cells, Gsk3b/Gsk3a phosphorylate splicing factors (Rbm8a, Srsf9, and Psf) and nucleolar proteins (Npm1 and Phf6); Gsk3b/Gsk3a are key to alternative splicing of close to 190 genes. (Gsk3 = glycogen synthase kinase-3; Rbm8a = RNA binding motif protein 8a; Srsf9 = splicing factor, arginine-serine-rich 9; Psf = replication protein Psf; Npm1 = nucleophosmin 1; Phf6 = PHD finger protein 6)
    Title: Phosphoproteomics reveals that glycogen synthase kinase-3 phosphorylates multiple splicing factors and is associated with alternative splicing.
  7. we first show that Eif4a3 haploinsufficiency phenocopies aberrant neurogenesis and microcephaly of Magoh and Rbm8a mutant mice.we show that genetic ablation of one downstream pathway, p53, significantly rescues microcephaly of all 3 EJC mutant
    Title: Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly.
  8. this data suggests a novel role of RBM8a in the regulation of neurodevelopment.
    Title: A critical role of RBM8a in proliferation and differentiation of embryonic neural progenitors.
  9. This is the first study that demonstrates the key role of RBM8a on the emotional behaviors in mice.
    Title: An EJC factor RBM8a regulates anxiety behaviors.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA export from nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of U2-type catalytic step 1 spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol NAS
Non-traceable Author Statement
more info
 PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
part_of exon-exon junction complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exon-exon junction complex ISO
Inferred from Sequence Orthology
more info
  
part_of exon-exon junction subcomplex mago-y14 ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
RNA-binding protein 8A
Names
RNA-binding motif protein 8A
ribonucleoprotein RBM8A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102407.1 → NP_001095877.1  RNA-binding protein 8A isoform a

    See identical proteins and their annotated locations for NP_001095877.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC122037, AI845155, AK082925, CJ072219
    Consensus CDS
    CCDS51005.1
    UniProtKB/Swiss-Prot
    A0A023T672, Q3UT38, Q6GTD4, Q9CWZ3, Q9D6U5
    UniProtKB/TrEMBL
    A0A0N4SUH6
    Related
    ENSMUSP00000143190.2, ENSMUST00000196456.5
    Conserved Domains (1) summary
    cd12324
    Location:67 → 151
    RRM_RBM8; RNA recognition motif (RRM) found in RNA-binding protein RBM8A, RBM8B nd similar proteins

  2. NM_025875.2 → NP_080151.2  RNA-binding protein 8A isoform b

    See identical proteins and their annotated locations for NP_080151.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC122037, AI845155, AK009953, CJ075560
    Consensus CDS
    CCDS79983.1
    UniProtKB/TrEMBL
    A0A0N4SUH6
    Related
    ENSMUSP00000044548.8, ENSMUST00000048915.11
    Conserved Domains (1) summary
    cd12324
    Location:66 → 150
    RRM_RBM8; RNA recognition motif (RRM) found in RNA-binding protein RBM8A, RBM8B nd similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    96537244..96541107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWZ3.4 GenPept UniProtKB/Swiss-Prot:Q9CWZ3

Gene LinkOut

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