Ms4a4b membrane-spanning 4-domains, subfamily A, member 4B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ms4a4bprovided by MGI
Official Full Name: membrane-spanning 4-domains, subfamily A, member 4Bprovided by MGI
Primary source: MGI:MGI:1913083
See related: Ensembl:ENSMUSG00000056290 AllianceGenome:MGI:1913083
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ly116; Chandra
Summary: Is integral component of plasma membrane. Orthologous to human MS4A4A (membrane spanning 4-domains A4A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in mammary gland adult (RPKM 17.7), spleen adult (RPKM 17.5) and 7 other tissues See more
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Genomic context

Location:: 19 A; 19 8.44 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (11420922..11440913)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (11443558..11463549)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MS4a4B regulated both T cell proliferation and T cell apoptosis.
Title: Anti-MS4a4B treatment abrogates MS4a4B-mediated protection in T cells and ameliorates experimental autoimmune encephalomyelitis.
TCR-stimulation induces transactivation of AP-1 transcription factor, which subsequently binds to the MS4a4B promoter and upregulates expression of MS4a4B in activated T cells.
Title: TCR stimulation upregulates MS4a4B expression through induction of AP-1 transcription factor during T cell activation.
Data indicate that MS4a4B negatively regulates T cell proliferation, and MS4a4B may serve as a modulator in the negative-feedback regulatory loop of activated T cells.
Title: MS4a4B, a CD20 homologue in T cells, inhibits T cell propagation by modulation of cell cycle.
study identified a molecular imprint of CD27-proficient CD4+ T cell help in CD8+ memory T cells in the form of the MS4A4B molecule
Title: CD27 instructs CD4+ T cells to provide help for the memory CD8+ T cell response after protein immunization.
MS4a4B expression is tightly regulated during T-cell development and MS4a4B expression promotes Th1 function and/or differentiation.
Title: Patterns of expression, membrane localization, and effects of ectopic expression suggest a function for MS4a4B, a CD20 homolog in Th1 T cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

AI463180 (e-PCR)
- UniSTS:186145

UniSTS:495977 (e-PCR)
- UniSTS:495977

Avpr1b (e-PCR), detects polymorphism
- UniSTS:495977

Gene Ontology Provided by MGI

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: membrane-spanning 4-domains, subfamily A, member 4B

Names: lymphocyte antigen 116

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.