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Nrip2 nuclear receptor interacting protein 2 [ Mus musculus (house mouse) ]

Gene ID: 60345, updated on 3-Apr-2024

Summary

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Official Symbol
Nrip2provided by MGI
Official Full Name
nuclear receptor interacting protein 2provided by MGI
Primary source
MGI:MGI:1891884
See related
Ensembl:ENSMUSG00000001520 AllianceGenome:MGI:1891884
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NIX1
Summary
Predicted to enable aspartic-type endopeptidase activity. Acts upstream of or within Notch signaling pathway and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in brain; heart; hypothalamus mantle layer; and telencephalon. Orthologous to human NRIP2 (nuclear receptor interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 9.0), frontal lobe adult (RPKM 3.6) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 F3; 6 62.99 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (128374780..128386747)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (128397818..128409780)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RAD9-HUS1-RAD1 interacting nuclear orphan 1 Neighboring gene forkhead box M1 Neighboring gene STARR-positive B cell enhancer ABC_E8833 Neighboring gene testis expressed 52 Neighboring gene STARR-positive B cell enhancer ABC_E4868 Neighboring gene integrin alpha FG-GAP repeat containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E4869 Neighboring gene FK506 binding protein 4 Neighboring gene predicted gene 10069 Neighboring gene STAM binding protein, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nuclear Receptor Interacting Protein-2 Mediates the Stabilization and Activation of β-Catenin During Podocyte Injury. Hou Q, et al. Front Cell Dev Biol, 2021. PMID 35004680, Free PMC Article
  2. Differential ligand-dependent protein-protein interactions between nuclear receptors and a neuronal-specific cofactor. Greiner EF, et al. Proc Natl Acad Sci U S A, 2000 Jun 20. PMID 10860982, Free PMC Article
  3. Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature. Fouillade C, et al. Arterioscler Thromb Vasc Biol, 2013 Jan. PMID 23117660, Free PMC Article
  4. A genomic atlas of mouse hypothalamic development. Shimogori T, et al. Nat Neurosci, 2010 Jun. PMID 20436479, Free PMC Article
  5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC144354

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nuclear receptor-interacting protein 2
Names
neuronal interacting factor 1
neuronal-interacting factor X 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162858.2 → NP_001156330.1  nuclear receptor-interacting protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001156330.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC116573
    Consensus CDS
    CCDS51917.1
    UniProtKB/Swiss-Prot
    Q14BZ2, Q3U0V7, Q3UYH0, Q9JHR9
    Related
    ENSMUSP00000113317.2, ENSMUST00000120405.4
    Conserved Domains (1) summary
    cl11403
    Location:110 → 199
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

  2. NM_001411379.1 → NP_001398308.1  nuclear receptor-interacting protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116573

  3. NM_001411380.1 → NP_001398309.1  nuclear receptor-interacting protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC116573

  4. NM_021717.3 → NP_068363.2  nuclear receptor-interacting protein 2 isoform 2

    See identical proteins and their annotated locations for NP_068363.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1, that results in a frameshift. It encodes isoform 2, which has a shorter and distinct C-terminus compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
    Source sequence(s)
    AC116573
    Consensus CDS
    CCDS20571.1
    UniProtKB/TrEMBL
    E9QAD1
    Related
    ENSMUSP00000001561.6, ENSMUST00000001561.12
    Conserved Domains (1) summary
    cl11403
    Location:110 → 206
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    128374780..128386747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506451.5 → XP_006506514.1  nuclear receptor-interacting protein 2 isoform X3

    UniProtKB/TrEMBL
    E9QAD1
    Conserved Domains (1) summary
    cl11403
    Location:110 → 199
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

  2. XM_006506449.5 → XP_006506512.1  nuclear receptor-interacting protein 2 isoform X1

    UniProtKB/TrEMBL
    E9QAD1
    Related
    ENSMUSP00000122558.2, ENSMUST00000123867.8
    Conserved Domains (1) summary
    cl11403
    Location:127 → 216
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

  3. XM_036152249.1 → XP_036008142.1  nuclear receptor-interacting protein 2 isoform X4

    Conserved Domains (1) summary
    cl11403
    Location:64 → 149
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

  4. XM_036152250.1 → XP_036008143.1  nuclear receptor-interacting protein 2 isoform X5

    Conserved Domains (1) summary
    cl11403
    Location:64 → 156
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JHR9.2 GenPept UniProtKB/Swiss-Prot:Q9JHR9

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