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Fign fidgetin [ Mus musculus (house mouse) ]

Gene ID: 60344, updated on 21-Apr-2024

Summary

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Official Symbol
Fignprovided by MGI
Official Full Name
fidgetinprovided by MGI
Primary source
MGI:MGI:1890647
See related
Ensembl:ENSMUSG00000075324 AllianceGenome:MGI:1890647
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
fi; Fgn; fidget
Summary
Enables protein C-terminus binding activity. Acts upstream of or within locomotory behavior. Located in nuclear matrix. Is expressed in central nervous system and heart. Orthologous to human FIGN (fidgetin, microtubule severing factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 2.5), CNS E11.5 (RPKM 2.2) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 C1.3; 2 37.19 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (63801852..63928382, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (63971508..64098038, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 23503 Neighboring gene STARR-seq mESC enhancer starr_04653 Neighboring gene predicted gene 8541 Neighboring gene STARR-seq mESC enhancer starr_04654 Neighboring gene STARR-seq mESC enhancer starr_04655 Neighboring gene STARR-seq mESC enhancer starr_04658 Neighboring gene STARR-seq mESC enhancer starr_04659 Neighboring gene STARR-seq mESC enhancer starr_04660 Neighboring gene STARR-seq mESC enhancer starr_04661 Neighboring gene predicted gene 13575 Neighboring gene STARR-seq mESC enhancer starr_04663 Neighboring gene Parkinson disease 7 domain containing 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Knockdown of Fidgetin Improves Regeneration of Injured Axons by a Microtubule-Based Mechanism. Matamoros AJ, et al. J Neurosci, 2019 Mar 13. PMID 30647150, Free PMC Article
  2. The position of fidget in linkage group V of the house mouse. CARTER TC. J Genet, 1951 Jan. PMID 24539707
  3. Functional characterization of fidgetin, an AAA-family protein mutated in fidget mice. Yang Y, et al. Exp Cell Res, 2005 Mar 10. PMID 15707573
  4. The cell cycle and retinal histogenesis fidget mutant mice. Konyukhov BV, et al. Dev Biol, 1976 Nov. PMID 1001817
  5. Lower Circulating Folate Induced by a Fidgetin Intronic Variant Is Associated With Reduced Congenital Heart Disease Susceptibility. Wang D, et al. Circulation, 2017 May 2. PMID 28302752

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of fidgetin improves regeneration of injured axons by a microtubule-based mechanism.
    Title: Knockdown of Fidgetin Improves Regeneration of Injured Axons by a Microtubule-Based Mechanism.
  2. fidgetin co-localized with endogenous AKAP95 in the nuclear matrix; AKAP95 mutant mice are surprisingly viable with no overt phenotype;mice carrying both Akap95 and fidget mutations die soon after birth due to cleft palate
    Title: Interaction between fidgetin and protein kinase A-anchoring protein AKAP95 is critical for palatogenesis in the mouse.
  3. Functional characterization of fidgetin.
    Title: Functional characterization of fidgetin, an AAA-family protein mutated in fidget mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule severing ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fidgetin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267846.1 → NP_001254775.1  fidgetin isoform 2

    See identical proteins and their annotated locations for NP_001254775.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional exon in the 5' coding region, which results in a downstream in-frame start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL928553, BC059266
    UniProtKB/Swiss-Prot
    Q9ERZ6
    Conserved Domains (3) summary
    TIGR01242
    Location:378 → 725
    26Sp45; 26S proteasome subunit P45 family
    pfam00004
    Location:511 → 641
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:712 → 745
    Vps4_C; Vps4 C terminal oligomerization domain

  2. NM_001267847.1 → NP_001254776.1  fidgetin isoform 2

    See identical proteins and their annotated locations for NP_001254776.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate segment in the 5' coding region, which results in a downstream in-frame start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK143787, AK164536, AL928553, BC059266
    UniProtKB/Swiss-Prot
    Q9ERZ6
    Conserved Domains (3) summary
    TIGR01242
    Location:378 → 725
    26Sp45; 26S proteasome subunit P45 family
    pfam00004
    Location:511 → 641
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:712 → 745
    Vps4_C; Vps4 C terminal oligomerization domain

  3. NM_021716.5 → NP_068362.1  fidgetin isoform 1

    See identical proteins and their annotated locations for NP_068362.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK163474, AL928553, BC059266
    Consensus CDS
    CCDS16070.1
    UniProtKB/Swiss-Prot
    Q3TPB0, Q3UP57, Q6PCM0, Q9ERZ6
    Related
    ENSMUSP00000122855.3, ENSMUST00000131615.9
    Conserved Domains (3) summary
    TIGR01242
    Location:389 → 736
    26Sp45; 26S proteasome subunit P45 family
    pfam00004
    Location:522 → 652
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:723 → 756
    Vps4_C; Vps4 C terminal oligomerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    63801852..63928382 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ERZ6.1 GenPept UniProtKB/Swiss-Prot:Q9ERZ6

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