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Wbp11 WW domain binding protein 11 [ Mus musculus (house mouse) ]

Gene ID: 60321, updated on 5-Mar-2024

Summary

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Official Symbol
Wbp11provided by MGI
Official Full Name
WW domain binding protein 11provided by MGI
Primary source
MGI:MGI:1891823
See related
Ensembl:ENSMUSG00000030216 AllianceGenome:MGI:1891823
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Npwbp; SIPP1; D6Wsu113e; 2510026P17Rik
Summary
Enables protein phosphatase regulator activity. Acts upstream of or within RNA splicing. Located in cytoplasm and nuclear speck. Is expressed in several structures, including blood; embryo ectoderm; embryo mesenchyme; extraembryonic component; and heart. Orthologous to human WBP11 (WW domain binding protein 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 80.0), CNS E11.5 (RPKM 24.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Wbp11 in Genome Data Viewer
Location:
6 G1; 6 66.72 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (136790652..136805214, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (136813654..136828216, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17608 Neighboring gene H4 histone 16 Neighboring gene H2J.A histone Neighboring gene STARR-seq mESC enhancer starr_17611 Neighboring gene cDNA sequence BC049715 Neighboring gene single-pass membrane protein with coiled-coil domains 3 Neighboring gene STARR-seq mESC enhancer starr_17612 Neighboring gene ADP-ribosyltransferase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Heterozygous loss of WBP11 function causes multiple congenital defects in humans and mice. Martin EMMA, et al. Hum Mol Genet, 2020 Dec 4. PMID 33276377, Free PMC Article
  2. Nucleocytoplasmic shuttling of the splicing factor SIPP1. Llorian M, et al. J Biol Chem, 2005 Nov 18. PMID 16162498
  3. WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif. Bedford MT, et al. Proc Natl Acad Sci U S A, 1998 Sep 1. PMID 9724750, Free PMC Article
  4. SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1. Llorian M, et al. Biochem J, 2004 Feb 15. PMID 14640981, Free PMC Article
  5. Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line. Shu H, et al. Mol Cell Proteomics, 2004 Mar. PMID 14729942

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of SIPP1 as a pre-mRNA splicing factor and a binding partner of protein phosphatase-1.
    Title: SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1.
  2. SIPP1 is a positive regulator of pre-mRNA splicing that is regulated by nucleocytoplasmic shuttling
    Title: Nucleocytoplasmic shuttling of the splicing factor SIPP1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables WW domain binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within RNA splicing IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
WW domain-binding protein 11
Names
Npw38-binding protein
WBP-11
splicing factor that interacts with PQBP-1 and PP1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021714.4 → NP_068360.4  WW domain-binding protein 11

    See identical proteins and their annotated locations for NP_068360.4

    Status: VALIDATED

    Source sequence(s)
    AC122804, AK041079
    Consensus CDS
    CCDS20655.1
    UniProtKB/Swiss-Prot
    O88539, Q3UMD8, Q8VDI0, Q923D5
    UniProtKB/TrEMBL
    Q3U6Q1
    Related
    ENSMUSP00000112213.2, ENSMUST00000116514.4
    Conserved Domains (1) summary
    pfam09429
    Location:12 → 92
    Wbp11; WW domain binding protein 11

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    136790652..136805214 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321693.1 → XP_017177182.1  WW domain-binding protein 11 isoform X1

    UniProtKB/Swiss-Prot
    O88539, Q3UMD8, Q8VDI0, Q923D5
    UniProtKB/TrEMBL
    Q3U6Q1
    Conserved Domains (1) summary
    pfam09429
    Location:12 → 92
    Wbp11; WW domain binding protein 11

  2. XM_030255522.1 → XP_030111382.1  WW domain-binding protein 11 isoform X1

    UniProtKB/Swiss-Prot
    O88539, Q3UMD8, Q8VDI0, Q923D5
    UniProtKB/TrEMBL
    Q3U6Q1
    Conserved Domains (1) summary
    pfam09429
    Location:12 → 92
    Wbp11; WW domain binding protein 11
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q923D5.2 GenPept UniProtKB/Swiss-Prot:Q923D5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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