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GPBP1L1 GC-rich promoter binding protein 1 like 1 [ Homo sapiens (human) ]

Gene ID: 60313, updated on 5-Mar-2024

Summary

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Official Symbol
GPBP1L1provided by HGNC
Official Full Name
GC-rich promoter binding protein 1 like 1provided by HGNC
Primary source
HGNC:HGNC:28843
See related
Ensembl:ENSG00000159592 AllianceGenome:HGNC:28843
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SP192
Summary
Predicted to enable DNA binding activity and RNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 44.4), thyroid (RPKM 35.1) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
1p34.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (45627304..45688110, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (45499652..45560916, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (46092976..46152205, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 833 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:46054000-46054500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:46054501-46055001 Neighboring gene MPRA-validated peak199 silencer Neighboring gene nuclear autoantigenic sperm protein Neighboring gene coiled-coil domain containing 17 Neighboring gene ribosomal protein S15a pseudogene 10 Neighboring gene ribosomal protein L7a pseudogene 16 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:46142481-46142981 Neighboring gene Sharpr-MPRA regulatory region 13545 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:46151821-46152419 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 987 Neighboring gene transmembrane protein 69 Neighboring gene intracisternal A particle-promoted polypeptide Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 834 Neighboring gene uncharacterized LOC105378693

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins. Tomkins JE, et al. Proteomics, 2018 May. PMID 29513927, Free PMC Article
  2. The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer. Tang W, et al. Nat Commun, 2019 Feb 8. PMID 30737378, Free PMC Article
  3. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Boldt K, et al. Nat Commun, 2016 May 13. PMID 27173435, Free PMC Article
  4. The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei. Nassa G, et al. Sci Data, 2019 Sep 16. PMID 31527615, Free PMC Article
  5. Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways. Rodriguez J, et al. Cell Rep, 2016 Mar 22. PMID 26972000, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
vasculin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021639.5 → NP_067652.1  vasculin-like protein 1

    See identical proteins and their annotated locations for NP_067652.1

    Status: VALIDATED

    Source sequence(s)
    BC022218, BC068578, BU627076
    Consensus CDS
    CCDS528.1
    UniProtKB/Swiss-Prot
    D3DQ10, Q9H751, Q9HC44
    Related
    ENSP00000347224.3, ENST00000355105.8
    Conserved Domains (1) summary
    pfam15337
    Location:380 → 459
    Vasculin; Vascular protein family Vasculin-like 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    45627304..45688110 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047427077.1 → XP_047283033.1  vasculin-like protein 1 isoform X2

  2. XM_024448810.2 → XP_024304578.1  vasculin-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DQ10, Q9H751, Q9HC44
    Conserved Domains (1) summary
    pfam15337
    Location:380 → 459
    Vasculin; Vascular protein family Vasculin-like 1

  3. XM_047427059.1 → XP_047283015.1  vasculin-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DQ10, Q9H751, Q9HC44

  4. XM_047427066.1 → XP_047283022.1  vasculin-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DQ10, Q9H751, Q9HC44

  5. XM_047427070.1 → XP_047283026.1  vasculin-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DQ10, Q9H751, Q9HC44

  6. XM_047427067.1 → XP_047283023.1  vasculin-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DQ10, Q9H751, Q9HC44

  7. XM_047427069.1 → XP_047283025.1  vasculin-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DQ10, Q9H751, Q9HC44

  8. XM_024448808.2 → XP_024304576.1  vasculin-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DQ10, Q9H751, Q9HC44
    Conserved Domains (1) summary
    pfam15337
    Location:380 → 459
    Vasculin; Vascular protein family Vasculin-like 1

  9. XM_047427075.1 → XP_047283031.1  vasculin-like protein 1 isoform X2

  10. XM_024448806.2 → XP_024304574.1  vasculin-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DQ10, Q9H751, Q9HC44
    Conserved Domains (1) summary
    pfam15337
    Location:380 → 459
    Vasculin; Vascular protein family Vasculin-like 1

  11. XM_047427076.1 → XP_047283032.1  vasculin-like protein 1 isoform X2

  12. XM_024448809.2 → XP_024304577.1  vasculin-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DQ10, Q9H751, Q9HC44
    Related
    ENSP00000290795.3, ENST00000290795.7
    Conserved Domains (1) summary
    pfam15337
    Location:380 → 459
    Vasculin; Vascular protein family Vasculin-like 1

  13. XM_017002019.3 → XP_016857508.1  vasculin-like protein 1 isoform X2

  14. XM_047427078.1 → XP_047283034.1  vasculin-like protein 1 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    45499652..45560916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338058.1 → XP_054194033.1  vasculin-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DQ10, Q9H751, Q9HC44

  2. XM_054338057.1 → XP_054194032.1  vasculin-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DQ10, Q9H751, Q9HC44

  3. XM_054338066.1 → XP_054194041.1  vasculin-like protein 1 isoform X2

  4. XM_054338059.1 → XP_054194034.1  vasculin-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DQ10, Q9H751, Q9HC44

  5. XM_054338055.1 → XP_054194030.1  vasculin-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DQ10, Q9H751, Q9HC44

  6. XM_054338056.1 → XP_054194031.1  vasculin-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DQ10, Q9H751, Q9HC44

  7. XM_054338060.1 → XP_054194035.1  vasculin-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DQ10, Q9H751, Q9HC44

  8. XM_054338061.1 → XP_054194036.1  vasculin-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DQ10, Q9H751, Q9HC44

  9. XM_054338064.1 → XP_054194039.1  vasculin-like protein 1 isoform X2

  10. XM_054338062.1 → XP_054194037.1  vasculin-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DQ10, Q9H751, Q9HC44

  11. XM_054338065.1 → XP_054194040.1  vasculin-like protein 1 isoform X2

  12. XM_054338054.1 → XP_054194029.1  vasculin-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DQ10, Q9H751, Q9HC44

  13. XM_054338063.1 → XP_054194038.1  vasculin-like protein 1 isoform X2

  14. XM_054338067.1 → XP_054194042.1  vasculin-like protein 1 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HC44.1 GenPept UniProtKB/Swiss-Prot:Q9HC44

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